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Necrotizing Gingivostomatitis Treatment Market Size and Forecast, by Type {Necrotizing Ulcerative Gingivitis (NUG), Necrotizing Ulcerative Periodontitis (NUP), Necrotizing Stomatitis (NS)}, Treatment (Antiseptic Rinses, Antibiotics, Gingival Grafting), Distribution Channel (Hospital Pharmacies, Medical Store, Online) - Growth Trends, Key Players, Regional Analysis 2026-2035

  • Report ID: 3570
  • Published Date: Nov 19, 2025
  • Report Format: PDF, PPT

Necrotizing Gingivostomatitis Treatment Market Outlook:

Necrotizing Gingivostomatitis Treatment Market size was valued at USD 18.94 million in 2025 and is likely to cross USD 36.23 million by 2035, expanding at more than 6.7% CAGR during the forecast period i.e., between 2026-2035. In the year 2026, the industry size of necrotizing gingivostomatitis treatment is estimated at USD 20.08 million.

Necrotizing Gingivostomatitis Treatment Market Overviews
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The growth of the market can be attributed to the increasing prevalence of gingivostomatitis in children across the world. The growing incidence of bacterial growth in the mouth owing to a lack of oral health habits is estimated to boost the market growth. Not brushing and flossing teeth on daily basis owing to a lack of awareness and education among illiterate people is expected to fuel the market growth in the coming years.  More than 70% of the American population brush their teeth only once a day as per the estimations in 2021.

The habit of oral sex with the infected person is also estimated to increase the risk of occurrence of gingivostomatitis in the people which thereby hike the market growth across the world. The growing use of antibiotics and over-the-counter (OTC) drugs for minor oral sores and injuries is also estimated to drive market growth. The market growth is also attributed to the increasing prevalence of HIV among adults owing to multiple sex partners or sex with an infected person. HIV makes the patient immunosuppressant leading to the incidence of more infections. According to the reports, the number of people in the U.S. living with HIV was estimated to be more than 1 million with over 33,000 new infections per annum during 2021.

Key Necrotizing Gingivostomatitis Treatment Market Insights Summary:

  • Regional Highlights:

    • By 2035, the North America region is projected to capture a 39% share in the Necrotizing Gingivostomatitis Treatment Market, supported by the rising burden of lifestyle disorders and unhealthy dietary habits.
    • The European market is estimated to hold a 22% share by 2035, propelled by the growing incidence of immune-suppressive conditions and poor lifestyle patterns.

  • Segment Insights:

    • The necrotizing ulcerative periodontitis (NUP) segment is anticipated to account for about 38% share by 2035 in the Necrotizing Gingivostomatitis Treatment Market, bolstered by the rising global prevalence of smoking and escalating stress levels.
    • The antiseptic rinses segment is expected to secure nearly 32% share by 2035, fueled by increasing tobacco use, alcohol consumption, and the need for effective bacterial cleansing to curb infection.

  • Key Growth Trends:

    • Increasing Incidences of Necrotizing Gingivostomatitis across the Globe
    • Poor Lifestyle and Weak Immunity of the People Suffering from Immune Suppressive Disorders

  • Major Challenges:

    • Circulation of Generic Drugs as They are Cost Efficient
    • High Rate of Side Effects from Antibiotics Use

  • Key Players: Novartis International AG, Teva Pharmaceutical Industries Ltd., Mylan N.V., Sanofi S.A., GlaxoSmithKline plc, Merck & Co., Inc., Otsuka Pharmaceutical Co., Ltd., Abbott Laboratories, Eli Lilly and Company, Hindustan Antibiotics Limited, Aviro Health L.P.

Global Necrotizing Gingivostomatitis Treatment Market Forecast and Regional Outlook:

  • Market Size & Growth Projections:

    • 2025 Market Size: USD 18.94 million
    • 2026 Market Size: USD 20.08 million
    • Projected Market Size: USD 36.23 million by 2035
    • Growth Forecasts: 6.7%

  • Key Regional Dynamics:

    • Largest Region: Asia Pacific (Majority Share by 2035)
    • Fastest Growing Region: North America
    • Dominating Countries: United States, China, India, Germany, United Kingdom
    • Emerging Countries: Brazil, Indonesia, Vietnam, Mexico, Turkey

    • Last updated on : 19 November, 2025

Growth Drivers

  • Increasing Incidences of Necrotizing Gingivostomatitis across the Globe – Gingivostomatitis is a regular mouth infection with symptoms of mouth and gum swelling. It is most common in children and is caused by herpes simplex virus type 1, coxsackievirus, poor oral hygiene, and by bacteria such as Streptococcus, and Actinomyces. Unhygienic health habits such as not brushing teeth and flossing are estimated to increase the occurrence of the disease thereby rising the market demand. The children are more prone to get the disease as they do not like to brush their teeth and parents need to be strict in maintaining the oral hygiene of their children. More than 0.4% to 10% of the population around the globe are affected by trench mouth or necrotizing gingivostomatitis and are around the age of 18 to 20 years as per the 2022 reports.

  • Poor Lifestyle and Weak Immunity of the People Suffering from Immune Suppressive Disorders – The percentage of people suffering from autoimmune diseases was estimated to be between over 4% to 7% in the U.S. as per the estimations of 2023.
  • Unhygienic Habits such as Not Washing Mouth Flossing Every Day – It was noted that worldwide more than 56% of people do not use floss and over 45% of people only floss once a week as of 2020 reports.
  • Increasing Use of Public Toilets Across the World with Increasing Travelling Rate – It is reported that in 2019, more than 58% of American residents used public restrooms or toilets a minimum of one to five times a week.
  • Increasing Number of People not Washing Their Hands After Using Bathroom – In 2020, more than 8% of people in the U.S. reported that they wash their hands once in a while and more than 3% of people do not wash their hands after using the washroom.

Challenges

  • Circulation of Generic Drugs as They are Cost Efficient
  • High Rate of Side Effects from Antibiotics Use – The increasing use of side effects of antibiotics includes rash, dizziness, diarrhea, nausea, and yeast infections. Also, other serious side effects include Clostridioides difficile infection that leads to diarrhea and severe colon damage, and eventually death. These side effects of medications are estimated to hamper the market growth in the coming years.
  • Increasing Home Care Treatments Across the World

Necrotizing Gingivostomatitis Treatment Market Size and Forecast:

Report Attribute Details

Base Year

2025

Forecast Year

2026-2035

CAGR

6.7%

Base Year Market Size (2025)

USD 18.94 million

Forecast Year Market Size (2035)

USD 36.23 million

Regional Scope

  • North America (U.S., and Canada)
  • Asia Pacific (Japan, China, India, Indonesia, Malaysia, Australia, South Korea, Rest of Asia Pacific)
  • Europe (UK, Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Latin America (Mexico, Argentina, Brazil, Rest of Latin America)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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Necrotizing Gingivostomatitis Treatment Market Segmentation:

Type {Necrotizing Ulcerative Gingivitis (NUG), Necrotizing Ulcerative Periodontitis (NUP), Necrotizing Stomatitis (NS)}

The global necrotizing gingivostomatitis treatment market is segmented and analyzed for demand and supply by type into necrotizing ulcerative gingivitis (NUG), necrotizing ulcerative periodontitis (NUP), and necrotizing stomatitis (NS). Out of the three types, the necrotizing ulcerative periodontitis segment is estimated to gain the largest market share of about 38% in the year 2035. The growth of the segment can be attributed to the increasing number of people who smoke regularly across the world. The growing stress, anxiety, and sleep deprivation are also estimated to rise the market growth. Over 75% of people across the U.S. are estimated to feel stress that causes physical illness as of 2022 reports. The use of antiseptic mouthwashes or oral antibiotics is used for the treatment of necrotizing ulcerative periodontitis. The practice of oral hygiene with oral medication and proper diet is believed to help during the recovery time of patients. The increasing consumption of antibiotics by most people across the globe as the first line of drug therapy is anticipated to drive market segment growth in the coming years. The list of antibiotics that are used in the treatment procedure includes amoxicillin, metronidazole, clavulanate, tetracyclines, and penicillins. The lack of awareness about hygienic practices and not maintaining any routine to prevent gum diseases is also estimated to fuel the growth of the market segment.

Treatment (Antiseptic Rinses, Antibiotics, Gingival Grafting)

The global necrotizing gingivostomatitis treatment market is also segmented and analyzed for demand and supply by treatment into antiseptic rinses, antibiotics, gingival grafting, and others. Amongst these segments, the antiseptic rinses segment is expected to garner a significant share of around 32% in the year 2035. The Increasing number of cases of drinking alcohol and chewing tobacco or smoking is estimated to drive the market growth. The use of antiseptic rinses is the best way to prevent or reduce the infection as it cleanses the bacteria grown on the surface without worsening further. The antiseptic rinses after brushing and eating remove harmful bacteria or microorganisms cleaning the area of infected gums. Antiseptic rinses help to regulate the formation of plaque and disrupt the bacteria in the mouth.

Our in-depth analysis of the global market includes the following segments:

     By Type
  • Necrotizing Ulcerative Gingivitis (NUG)
  • Necrotizing Ulcerative Periodontitis (NUP)
  • Necrotizing Stomatitis (NS)

 

   By Treatment
  • Antiseptic Rinses
  • Antibiotics
  • Gingival Grafting
  • Others

 

    By Distribution Channel
  • Hospital Pharmacies
  • Medical Store
  • Online
  • Others

 
Vishnu Nair
Vishnu Nair
Head - Global Business Development

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Necrotizing Gingivostomatitis Treatment Market - Regional Analysis

North American Market Forecast

North America industry is expected to hold largest revenue share of 39% by 2035. The growth of the market can be attributed majorly to the high prevalence of lifestyle diseases, caused by inactive routines, busy lifestyles, and unhealthy eating habits. According to data from the Centers for Disease Control and Prevention, over 45% of Americans suffer from at least one chronic disease in the U.S. The increasing preference for outside food and a growing number of people eating ready-made and fast foods owing to the growing working population is estimated to propel the market growth in the coming years. Also, an improper diet with no nutrients is estimated to drive market growth. The increasing number of people consuming spicy foods that do not contain any nutritional value is estimated to boost the market growth. Intake of food with no proper proteins or vitamins and increasing changes in eating habits also drive the market growth.  

Europe Market Forecast

The European necrotizing gingivostomatitis treatment market is estimated to be the second largest, registering a share of about 22% by the end of 2035. The growth of the market can be attributed majorly to the largely Caucasian population, and the poor lifestyle of the people in developed nations. Over 50 million people in Europe suffer from chronic conditions. The rising number of people suffering from immune suppressive disorders across the region owing to aging and genetic disorders is estimated to drive the growth of the market. Unhygienic healthcare habits such as not washing hands after using restrooms are also estimated to propel the market growth in the coming years. Increasing preference for fast foods as they taste good and do not require much time for preparation as more people started working jobs is also estimated to drive the market growth during the forecast period. Also, the market growth is attributed to many people in the region suffering from periodontitis with increasing incidence in the elder population. The cost of oral health services is very high in the region which is estimated to drive the market growth.

APAC Market Statistics

Further, the market in the Asia Pacific, amongst the market in all the other regions, is projected to hold a majority of the share by the end of 2035. The growth of the market can be attributed majorly to the rising dehydration among people owing to a lack of concentration on health and more involvement in work. The growing number of people with mouth ulcers and blisters caused by stress and sleep deprivation is expected to fuel the market growth. The increasing number of people suffering from gum diseases owing to the lack of education in some countries leads to the development of serious infections causing gingivostomatitis which is estimated to hike the market growth. Also, using the same razors unknowingly by local barber shops and the same makeup products by beauticians increases the chances of disease occurrence which in turn propels the market growth. The lack of government programs to educate the slum areas about the complications caused by not washing hands after using public toilets is estimated to propel the market growth.

Necrotizing Gingivostomatitis Treatment Market shares
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Necrotizing Gingivostomatitis Treatment Market Players:

    • Novartis International AG
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Teva Pharmaceutical Industries Ltd.
    • Mylan N.V.
    • Sanofi S.A.
    • GlaxoSmithKline plc
    • Merck & Co., Inc.
    • Otsuka Pharmaceutical Co., Ltd.
    • Abbott Laboratories
    • Eli Lilly and Company
    • Hindustan Antibiotics Limited
    • Aviro Health L.P.

Recent Developments

  • GlaxoSmithKline plc conducted an online survey in five European countries with 4,500 people to study the relationship between poor oral hygiene and disease complications. The conclusion of the study showed that there was a need to raise public awareness regarding the impact of oral hygiene on overall health.

  • Aviro Health L.P. declared that it granted the award of investigator-initiated research (IIR) grant to the University of Pennsylvania School of Dental Medicine Center for Clinical and Translational Research to investigate and report the effectiveness of povidone-iodine antiseptic oral rinse in removing COVID-19 virus or SARS-CoV-2 virus in the mouth.

  • Report ID: 3570
  • Published Date: Nov 19, 2025
  • Report Format: PDF, PPT
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Frequently Asked Questions (FAQ)

In the year 2026, the industry size of necrotizing gingivostomatitis treatment is estimated at USD 20.08 million.

The global necrotizing gingivostomatitis treatment market size was around USD 18.94 million in 2025 and is likely to expand at a CAGR of more than 6.7%, surpassing USD 36.23 million revenue by 2035.

By 2035, the North America region is projected to capture a 39% share in the Necrotizing Gingivostomatitis Treatment Market, supported by the rising burden of lifestyle disorders and unhealthy dietary habits.

Key players in the market include Novartis International AG, Teva Pharmaceutical Industries Ltd., Mylan N.V., Sanofi S.A., GlaxoSmithKline plc, Merck & Co., Inc., Otsuka Pharmaceutical Co., Ltd., Abbott Laboratories, Eli Lilly and Company, Hindustan Antibiotics Limited, Aviro Health L.P.

Necrotizing Gingivostomatitis Treatment Market Report Scope

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