Tangential Flow Filtration Market Size & Share, by Product (Systems, Membrane Filters, Accessories); Material {Polyether Sulfone (PS), Polyvinylidene Difluoride (PVDF), Regenerated Cellulose}; Technique (Ultrafiltration, Microfiltration); Application (Bioprocess, Viral Vector, Vaccine Purification) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2023-2035

  • Report ID: 4839
  • Published Date: Apr 17, 2023
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2023-2035

Tangential Flow Filtration Market size is projected to surpass USD 15 Billion by the end of 2035, growing at a CAGR of 16.20% during the forecast period, i.e., 2023-2035.In the year 2022, the industry size of the tangential flow filtration was over USD 3 Billion. The growth of the market can be attributed to the advances in biological science as well as the booming biotechnology sector along with the accelerating bio revolution globally. As per researchers, biological applications alone are anticipated to have a direct positive economic impact of up to ~USD 4 trillion a year over the next ten to 20 years.

In addition to these, factors that are believed to fuel the market growth of tangential flow filtration include the rise in biological innovations as well as the rapid introduction of clinical trials of vaccines, besides the search for effective therapies along with genome sequencing, and a deep investigation of both the origins and the transmission patterns of the virus. For instance, responses to the novel coronavirus—SARS-CoV-2, worldwide, illustrated substantial advances in biological science in just the past few years post-COVID-19. The speedy genome sequencing of the virus in a few weeks is a witness to the new world of biology. All these research and developments in the field of protein chemistry, immunology, molecular biology, biochemistry, and microbiology are predicted to present the potential for market expansion over the projected period.

Tangential Flow Filtration Market
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Tangential Flow Filtration Sector: Growth Drivers and Challenges

Growth Drivers

  • Increasing Revenue of Cell and Gene Therapy – with gene therapy holding a promise to treat a wide range of diseases, such as heart disease, cancer, cystic fibrosis, diabetes, hemophilia, and AIDS whose ubiquity is rising worldwide, the revenue growth of these therapies depicts an upsurge. For instance, as per projections, between 2021-2026 the sales of cell and gene therapies are anticipated to rise from USD 4 billion to nearly USD 45 billion a year. Moreover, as large-scale purification of viruses and viral vectors for gene therapy applications and viral vaccines can be attained with the use of TFF, the rising investment in gene therapy is anticipated to boost market growth.
  • Growing Sales of Biotech drugs and Biologics – global sales from biotechnology drugs amounted to over USD 400 billion in 2022. With the rising share of biotech drugs, the TFF market is anticipated to grow continuously as TFF is used in almost every biopharmaceutical manufacturing downstream process to provide gentle, fast concentration, and diafiltration.
  • Increasing Global Burden of Diseases –As per an estimation over 877,500 Americans die every year due to heart disease or stroke, accounting for nearly one-third of all deaths. With the technological advancements in the field of biotechnology, it is anticipated that a minimum of 45% of the current global disease burden can be addressed using biological development. This, as a result, is expected to boost market growth.
  • Widening Scope of Tissue Engineering and Regenerative Medicine – The expansion in the field of bioengineering as well as biomedicine can be attributed to the growing employment of bioengineers and biomedical engineers which in the United States is projected to rise nearly 10% between 2021 to 2031. This expansion is expected to boost the market growth as applications of TFF involve its use for clarification and removal of cells, as well as cellular debris from cell culture broths.


  • High capital expenditure – The rising need for huge capital investments at the initial stage of setting up new production facilities is a major restraining factor to the market growth. Owing to this the survival of small players and new entrants is found difficult, which is hampering the market growth. Moreover, the stringent regulatory policies of the government are projected to challenge the tangential flow filtration market.
  • Easy availability of substitutes
  • Complex & changing product requirements

Tangential Flow Filtration Market: Key Insights

Base Year


Forecast Year




Base Year Market Size (2022)

~ USD 3 Billion

Forecast Year Market Size (2035)

~ USD 15 Billion

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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Tangential Flow Filtration Segmentation

Technique (Ultrafiltration, Microfiltration)

The global tangential flow filtration market is segmented and analyzed for demand and supply by technique into ultrafiltration, microfiltration, and other techniques. Out of these techniques of tangential flow filtration, the ultrafiltration segment is estimated to gain the largest market share of about ~38% in the year 2035. The growth of the segment can be attributed to the rising prevalence of infectious diseases globally, including coronavirus, influenza A virus, and others as well as the increasing investment in research and development (R&D) in the field of biomedicine. According to the World Health Organization, the annual epidemics of seasonal influenza are responsible for about 3 to 5 million cases of severe illness, and nearly 290 000 to 650 000 respiratory deaths.

Application (Bioprocess, Viral Vector, Vaccine Purification)

The global tangential flow filtration market is also segmented and analyzed for demand and supply by application into bioprocess, viral vector, vaccine purification, and others. Amongst these segments, the viral vector segment is expected to garner a significant share of around ~46% in the year 2035. The expanding R&D in the field of molecular biology as well as the rising clinical trials of cell therapies are anticipated to boost the segment growth over the forecast period. On the other hand, the bioprocess segment is projected to witness a massive CAGR during the forecast period, owing to the rapidly rising demand for biological products with the growing biotechnology and biopharmaceutical industries. This, as a result, is anticipated to create numerous opportunities for the growth of the segment in the coming years.

Our in-depth analysis of the global market includes the following segments:

            By Product

  • Systems
  • Membrane Filters
  • Accessories

           By Material

  • Polyether Sulfone (PS)
  • Polyvinylidene Difluoride (PVDF)
  • Regenerated Cellulose
  • Others

           By Technique

  • Ultrafiltration
  • Microfiltration
  • Others

         By Application

  • Bioprocess
  • Viral Vector
  • Vaccine Purification
  • Others

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Tangential Flow Filtration Industry - Regional Synopsis

North American Market Forecast

The tangential flow filtration market in North America is projected to be the largest with a share of about ~35% by the end of 2035. The growth of the market can be attributed majorly to the increasing growing investment in R&D in the biopharmaceutical sector as well as growing advancements in the field of biotechnology along with rising employment of tangential flow filtration methods for the separation and purification of biomolecules in the area of biological fields. For instance, it was found that the biopharmaceutical industry in the U.S. invested around USD 102 billion into R&D in 2018.

APAC Market Statistics

The Asia Pacific tangential flow filtration market is estimated to be the second largest, registering a share of about ~30% by the end of 2035. The growth of the market can be attributed majorly to the growing existence of giant pharmaceutical manufacturers as well as increasing R&D in the field of biopharmaceuticals along with the rising inventions as well as innovations in the field of biologics and vaccines. The increase of CMOs in developing nations like China, Japan, and South Korea is another driving factor that leads to the market growth, as is the rising demand for biologics and pharmaceuticals, a sizable infusion of capital from domestic and foreign businesses, and these factors together. The desire for low-cost therapies, the modernization of medical procedures, and these factors will all contribute to the expansion of the TFF market in the region. Moreover, the uptrend installations of smaller bioreactors and multiproduct manufacturing facilities that have increased the demand for plug-and-play single-use TFF devices are also expected to boost the market growth in the region.

Europe Market Forecast

Further, the tangential flow filtration market in Europe is projected to hold a majority of the share by the end of 2035. The increasing level of funding and investment by the government as well as the widening scope of biopharmaceuticals with the development of novel biological products are factors attributed to the growth of the market in the European region in the upcoming years.

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Tangential Flow Filtration Market Size
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Companies Dominating the Tangential Flow Filtration Landscape

    • Donaldson Company
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Merck KGaA
    • Solaris Biotechnology Srl.
    • Sartorius AG
    • Repligen Corporation
    • Sterlitech Corporation
    • Parker Hannifin Corp
    • Cole-Parmer Instrument Company, LLC.
    • Koch Membrane Systems, Inc.
    • Synder Filtration, Inc



In The News

  • Merck KGaA, the vibrant science and technology company, introduced three new products to support the flexible manufacturing of biologics, including first-of-its-kind single-use tangential flow filtration capsules for bioprocessing of antibody-drug conjugates and monoclonal antibodies.

  • Donaldson Company, a leading provider of innovative filtration products and solutions worldwide, acquired Solaris Biotechnology Srl. The lateral company designs and manufactures bioprocessing equipment, including bioreactors, fermenters, and tangential flow filtration systems for use in food and beverage, biotechnology, and other life sciences markets.

Author Credits:  Radhika Gupta, Shivam Bhutani

  • Report ID: 4839
  • Published Date: Apr 17, 2023
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

The increasing spending in the field of protein chemistry, immunology, molecular biology, biochemistry, and microbiology are the major factors driving the market growth.

The market size of tangential flow filtration is anticipated to attain a CAGR of 16.20% over the forecast period, i.e., 2023-2035.

The requirement of the huge cost of capital as well as changing market demand are estimated to be the growth hindering factors for the market expansion.

The market in the North American region is projected to hold the largest market share by the end of 2035 and provide more business opportunities in the future.

The major players in the market are Merck KGaA, Solaris Biotechnology Srl., Sartorius AG, Repligen Corporation, Sterlitech Corporation, and Parker Hannifin Corp.

The company profiles are selected based on the revenues generated from the product segment, the geographical presence of the company which determines the revenue generating capacity as well as the new products being launched into the market by the company.

The market is segmented by product, material, technique, application, and by region.

The ultrafiltration segment is anticipated to garner the largest market size by the end of 2035 and display significant growth opportunities.
Tangential Flow Filtration Market Report Scope

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