2D Chromatography Market Size & Share, by Product (2D Gas, Liquid Chromatography Products); Application (Life Science Research, Environmental Analysis, Food & Beverage Testing, Petrochemical & Natural Gas Analysis); End-user (Hospitals, Biotechnology, Pharmaceutical, Cancer Research Laboratories, Ambulatory Surgery Centers, Agriculture, Food Industries, Specialty Clinics) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2023-2035

  • Report ID: 4590
  • Published Date: Feb 26, 2023
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2023-2035

2D Chromatography Market size is poised to reach USD 4 Billion by the end of 2035, growing at a CAGR of 11% during the forecast period, i.e., 2023-2035. In the year 2022, the industry size of 2D chromatography was USD 2 Billion. The reason behind the growth is impelled by rising growth and development in the petrochemical industry. Gas chromatography is essential in the petrochemical sector since it helps in monitoring and assessing the quality of oil. Moreover, even the smallest amount of contamination in crude oil could significantly lower its effectiveness, elemental separation is essential for the crude oil that all humans rely on in one way or another.

Gas chromatography could be used by petroleum professionals to remove dangerous components from the mixture. In addition, liquid chromatography is also extensively used in the petroleum industry to investigate the oil before exporting. By 2050, it is anticipated that petrochemicals would account for more than 40% of the increase in oil demand.

The elevating cases of cancer are believed to fuel market growth. To identify the information or state of a person’s cancer biomarkers such as genes, and proteins are tested. Two-dimensional chromatography is an effective method for separating chemicals from complicated mixtures, and it is being utilized more frequently for biomarker research associated with several kinds of cancer by analyzing complex biological samples.

Besides this, it is also used in drug discovery and monitoring the cancer treatment response. As per the estimates, about 2 million new cancer cases were diagnosed in 2022, along with 6, 00,000 deaths in the US.

2D Chromatography Market
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2D Chromatography Sector: Growth Drivers and Challenges

Growth Drivers

  • Rising Concern about Sanitation and Food Safety Globally, people are becoming more worried about the hygiene of the food they are having which has increased awareness about food safety and people are interested to know more about the production, manufacturing, and packaging of food products. Moreover, after the pandemic, the virus contamination risk is the major factor people are worried about. All these factors are expected to rise the demand for 2D chromatography since it is a potent instrument for the analysis of food and food products which is ideally adapted for the separation of vitamins and other food & beverage chemicals. For instance, it is observed that over 10% of people worldwide felt that improving food safety is the responsibility of the manufacturer and the government should implement the same.
  • Growing Applications in Biochemical Studies- To understand the biological processes 2D chromatography is being applied in several biochemical studies to separate enzyme substrates.


  • Lack of Awareness and Skilled Professionals– 2D chromatography is a very complex process and hence requires trained and skilled personnel to handle the process. It is deployed to carry out various complex real-world samples. For instance, in the oil industry, the oil needs to be purified which contains various chemicals. Therefore, to carry out the task efficiently the urge is growing for trained professionals. However, many 2D chromatography are facing a scarcity of trained workers. Hence, this factor is estimated to hinder the growth of the market.
  • High Cost of 2D Chromatography Systems
  • Rising Inclination Towards 3D Chromatography

2D Chromatography Market: Key Insights

Base Year


Forecast Year




Base Year Market Size (2022)

~ USD 2 Billion

Forecast Year Market Size (2035)

~ USD 4 Billion

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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2D Chromatography Segmentation

Product (2D Gas, Liquid Chromatography Products)

The 2D gas segment is estimated to hold 40% share of the 2D chromatography market in the coming years owing to the rising concerns regarding environmental pollution. From 1970 to 2020, the emission levels of six common pollutants including ozone, lead, carbon monoxide, nitrogen dioxide, sulfur dioxide, and particles are reduced by 78% with the implementation of the Clean Air Act as per the United States Environmental Protection Agency.

Further, chromatography is extensively used in analyzing and investigating aspects that lead to pollution. Moreover, techniques for 2D chromatography are often used to separate and measure trace amounts of dangerous compounds in mixtures and to assess pollution levels in water, soil, and air. Hence, further estimated to be an aid to reduce pollution.

End-User (Hospitals, Biotechnology, Pharmaceutical Sector, Cancer Research Laboratories, Ambulatory Surgery Centers, Agriculture and Food Industries, Specialty Clinics)

2D chromatography market from the biotechnology and pharmaceutical sector segment is set to garner a notable share shortly owing to an increase in research & development by the pharmaceutical sector. A common analytical method used in the pharmaceutical sector is liquid chromatography. Moreover, to provide the lowest danger to the patients, all manufactured products in the pharmaceutical sector must be of the highest quality. Hence, researchers employ a variety of tools and analytical procedures, such as liquid chromatography, during the development process to ensure that products meet specific criteria.

Globally, the pharmaceutical sector spent over USD 230 billion on research and development in 2021.

Our in-depth analysis of the global market includes the following segments:


  • 2D Gas
  • Liquid Chromatography Products


  • Life Science Research
  • Environmental Analysis
  • Food & Beverage Testing
  • Petrochemical & Natural Gas Analysis

     End User

  • Hospitals
  • Biotechnology
  • Pharmaceutical Sector
  • Cancer Research Laboratories
  • Ambulatory Surgery Centers
  • Agriculture and Food Industries
  • Specialty Clinics

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2D Chromatography Industry - Regional Synopsis

North American Market Forecast

2D Chromatography market in North America is predicted to account for the largest share of over 32% by the end of 2035 impelled by the growing use of heating oil by households. As a result, energy consumption is expected to increase in the region which has also raised environmental concerns. This has driven the demand for 2D chromatography as a means for pollution control and in research areas related to energy, and sustainability.

As per the U.S Energy Information Administration, in the US during winter in 2019, the household consumption of heating oil was about 400 gallons which increased to more than 500 gallons by doubling the consumption of oil in 2022.

APAC Market Statistics

The Asia Pacific 2D Chromatography market is estimated to be the second largest, during the forecast timeframe led by the growing need for the separation of the active ingredients of herbal Chinese medicine. It is usually challenging to separate the active elements such as herbal extracts used in traditional Chinese medicine (TCM), which frequently contain a variety of components with different polarities. Owing to its higher peak capacity and resolution compared to one-dimensional liquid chromatography, high-performance liquid chromatography with rapid capillary electrophoresis (-HPLC-CE) is more effective for the separation of complicated traditional Chinese medicines.

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2D Chromatography Market Size
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Companies Dominating the 2D Chromatography Landscape

    • Merck KGaA
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Agilent Technologies, Inc.
    • LECO Corporation
    • Waters Corporation
    • Shimadzu Corporation
    • Restek Corporation
    • SepSolve Analytical Ltd.
    • Danaher Corporation
    • Bio-Rad Laboratories, Inc.
    • Thermo Fisher Scientific Holdings, Inc.


In The News

  • Shimadzu Corporation announced the release of the LCMS-2050 high-performance liquid chromatograph mass spectrometer (LC-MS). The main motive for this was to increase the sale of LCMS-2050 by two times.
  • Thermo Fisher Scientific Holdings, Inc. introduced online 2D-liquid chromatography (LC) systems to provide the highest degree of application adaptability and diversity for multidimensional liquid chromatography in fields including pharmaceutical/biopharmaceutical R&D, food safety, environmental testing, and polymer analysis

Author Credits:  Radhika Gupta, Shivam Bhutani

  • Report ID: 4590
  • Published Date: Feb 26, 2023
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

Rising growth and development in the petrochemical industry and the elevating cases of cancer are the major factors driving the growth of the market.

The market size of 2D chromatography is anticipated to attain a CAGR of 11% over the forecast period, i.e., 2023 – 2035.

The major players in the market are Fujifilm Corporation, Cardinal Health, Inc., DTR Medical Ltd, B. Braun Melsungen AG, Becton, Dickinson and Company, Olympus Corporation, Hologic Inc., Medtronic Limited, and others.

The 2D gas segment is anticipated to garner the largest market size by the end of 2035 and display significant growth opportunities.

The market in the North America region is projected to hold the largest market share by the end of 2035 and provide more business opportunities in the future.
2D Chromatography Market Report Scope

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