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2D Chromatography Market Size and Forecast, by Product (2D Gas, Liquid Chromatography Products), Application (Life Science Research, Environmental Analysis, Food & Beverage Testing, Petrochemical & Natural Gas Analysis), End-user (Hospitals, Biotechnology, Pharmaceutical, Cancer Research Laboratories, Ambulatory Surgery Centers, Agriculture, Food Industries, Specialty Clinics) - Growth Trends, Key Players, Regional Analysis 2026-2035

  • Report ID: 4590
  • Published Date: Nov 24, 2025
  • Report Format: PDF, PPT
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2D Chromatography Market Outlook:

2D Chromatography Market size was valued at USD 2.93 billion in 2025 and is expected to reach USD 8.39 billion by 2035, registering around 11.1% CAGR during the forecast period i.e., between 2026-2035. In the year 2026, the industry size of 2D chromatography is evaluated at USD 3.22 billion.

2D Chromatography Market Size
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The reason behind the growth is impelled by rising growth and development in the petrochemical industry. Gas chromatography is essential in the petrochemical sector since it helps in monitoring and assessing the quality of oil. Moreover, even the smallest amount of contamination in crude oil could significantly lower its effectiveness, elemental separation is essential for the crude oil that all humans rely on in one way or another.

Gas chromatography could be used by petroleum professionals to remove dangerous components from the mixture. In addition, liquid chromatography is also extensively used in the petroleum industry to investigate the oil before exporting. By 2050, it is anticipated that petrochemicals would account for more than 40% of the increase in oil demand.

The elevating cases of cancer are believed to fuel market growth. To identify the information or state of a person’s cancer biomarkers such as genes, and proteins are tested. Two-dimensional chromatography is an effective method for separating chemicals from complicated mixtures, and it is being utilized more frequently for biomarker research associated with several kinds of cancer by analyzing complex biological samples.

Besides this, it is also used in drug discovery and monitoring the cancer treatment response. As per the estimates, about 2 million new cancer cases were diagnosed in 2022, along with 6, 00,000 deaths in the US.

Key 2D Chromatography Market Insights Summary:

  • Regional Highlights:

    • By 2035, North America is set to secure a 32% share of the 2D Chromatography Market, supported by expanding household heating-oil usage impelled by the growing use of heating oil by households.
    • By 2035, the Asia Pacific region is expected to remain the second-largest contributor as advanced separation techniques gain traction in traditional Chinese medicine applications owing to the growing need for the separation of the active ingredients of herbal Chinese medicine.

  • Segment Insights:

    • By 2035, the 2D gas segment is projected to command a 40% share of the 2D Chromatography Market during 2026–2035, supported by strengthened environmental analysis frameworks owing to the rising concerns regarding environmental pollution.
    • By 2035, the biotechnology and pharmaceutical sector segment is anticipated to garner a notable share as analytical robustness becomes increasingly essential in development workflows owing to an increase in research & development by the pharmaceutical sector.

  • Key Growth Trends:

    • Rising Concern about Sanitation and Food Safety
    • Growing Applications in Biochemical Studies

  • Major Challenges:

    • Lack of Awareness and Skilled Professionals
    • High Cost of 2D Chromatography Systems

  • Key Players: Merck KGaA, Agilent Technologies, Inc., LECO Corporation, Waters Corporation, Shimadzu Corporation, Restek Corporation, SepSolve Analytical Ltd., Danaher Corporation, Bio-Rad Laboratories, Inc., Thermo Fisher Scientific Holdings, Inc.

Global 2D Chromatography Market Forecast and Regional Outlook:

  • Market Size & Growth Projections:

    • 2025 Market Size: USD 2.93 billion
    • 2026 Market Size: USD 3.22 billion
    • Projected Market Size: USD 8.39 billion by 2035
    • Growth Forecasts: 11.1%

  • Key Regional Dynamics:

    • Largest Region: North America (32% Share by 2035)
    • Fastest Growing Region: Asia Pacific
    • Dominating Countries: United States, China, Germany, Japan, United Kingdom
    • Emerging Countries: India, South Korea, Singapore, Brazil, Australia

    • Last updated on : 24 November, 2025

Growth Drivers

  • Rising Concern about Sanitation and Food Safety Globally, people are becoming more worried about the hygiene of the food they are having which has increased awareness about food safety and people are interested to know more about the production, manufacturing, and packaging of food products. Moreover, after the pandemic, the virus contamination risk is the major factor people are worried about. All these factors are expected to rise the demand for 2D chromatography since it is a potent instrument for the analysis of food and food products which is ideally adapted for the separation of vitamins and other food & beverage chemicals. For instance, it is observed that over 10% of people worldwide felt that improving food safety is the responsibility of the manufacturer and the government should implement the same.
     
  • Growing Applications in Biochemical Studies- To understand the biological processes 2D chromatography is being applied in several biochemical studies to separate enzyme substrates.

Challenges

  • Lack of Awareness and Skilled Professionals– 2D chromatography is a very complex process and hence requires trained and skilled personnel to handle the process. It is deployed to carry out various complex real-world samples. For instance, in the oil industry, the oil needs to be purified which contains various chemicals. Therefore, to carry out the task efficiently the urge is growing for trained professionals. However, many 2D chromatography are facing a scarcity of trained workers. Hence, this factor is estimated to hinder the growth of the market.
  • High Cost of 2D Chromatography Systems
  • Rising Inclination Towards 3D Chromatography

2D Chromatography Market Size and Forecast:

Report Attribute Details

Base Year

2025

Forecast Year

2026-2035

CAGR

11.1%

Base Year Market Size (2025)

USD 2.93 billion

Forecast Year Market Size (2035)

USD 8.39 billion

Regional Scope

  • North America (U.S., and Canada)
  • Asia Pacific (Japan, China, India, Indonesia, Malaysia, Australia, South Korea, Rest of Asia Pacific)
  • Europe (UK, Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Latin America (Mexico, Argentina, Brazil, Rest of Latin America)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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2D Chromatography Market Segmentation:

Product Segment Analysis

The 2D gas segment is estimated to hold 40% share of the 2D chromatography market in the coming years owing to the rising concerns regarding environmental pollution. From 1970 to 2020, the emission levels of six common pollutants including ozone, lead, carbon monoxide, nitrogen dioxide, sulfur dioxide, and particles are reduced by 78% with the implementation of the Clean Air Act as per the United States Environmental Protection Agency.

Further, chromatography is extensively used in analyzing and investigating aspects that lead to pollution. Moreover, techniques for 2D chromatography are often used to separate and measure trace amounts of dangerous compounds in mixtures and to assess pollution levels in water, soil, and air. Hence, further estimated to be an aid to reduce pollution.

End-User Segment Analysis

2D chromatography market from the biotechnology and pharmaceutical sector segment is set to garner a notable share shortly owing to an increase in research & development by the pharmaceutical sector. A common analytical method used in the pharmaceutical sector is liquid chromatography. Moreover, to provide the lowest danger to the patients, all manufactured products in the pharmaceutical sector must be of the highest quality. Hence, researchers employ a variety of tools and analytical procedures, such as liquid chromatography, during the development process to ensure that products meet specific criteria.

Globally, the pharmaceutical sector spent over USD 230 billion on research and development in 2021.

Our in-depth analysis of the global market includes the following segments:

     Product
  • 2D Gas
  • Liquid Chromatography Products

     Application
  • Life Science Research
  • Environmental Analysis
  • Food & Beverage Testing
  • Petrochemical & Natural Gas Analysis

     End User
  • Hospitals
  • Biotechnology
  • Pharmaceutical Sector
  • Cancer Research Laboratories
  • Ambulatory Surgery Centers
  • Agriculture and Food Industries
  • Specialty Clinics
Vishnu Nair
Vishnu Nair
Head - Global Business Development

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2D Chromatography Market - Regional Analysis

North American Market Insights

North America industry is poised to dominate majority revenue share of 32% by 2035, impelled by the growing use of heating oil by households. As a result, energy consumption is expected to increase in the region which has also raised environmental concerns. This has driven the demand for 2D chromatography as a means for pollution control and in research areas related to energy, and sustainability.

As per the U.S Energy Information Administration, in the US during winter in 2019, the household consumption of heating oil was about 400 gallons which increased to more than 500 gallons by doubling the consumption of oil in 2022.

APAC Market Insights

The Asia Pacific 2D Chromatography market is estimated to be the second largest, during the forecast timeframe led by the growing need for the separation of the active ingredients of herbal Chinese medicine. It is usually challenging to separate the active elements such as herbal extracts used in traditional Chinese medicine (TCM), which frequently contain a variety of components with different polarities. Owing to its higher peak capacity and resolution compared to one-dimensional liquid chromatography, high-performance liquid chromatography with rapid capillary electrophoresis (-HPLC-CE) is more effective for the separation of complicated traditional Chinese medicines.

2D Chromatography Market Share
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2D Chromatography Market Players:

    • Merck KGaA
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Agilent Technologies, Inc.
    • LECO Corporation
    • Waters Corporation
    • Shimadzu Corporation
    • Restek Corporation
    • SepSolve Analytical Ltd.
    • Danaher Corporation
    • Bio-Rad Laboratories, Inc.
    • Thermo Fisher Scientific Holdings, Inc.

Recent Developments

  • Shimadzu Corporation announced the release of the LCMS-2050 high-performance liquid chromatograph mass spectrometer (LC-MS). The main motive for this was to increase the sale of LCMS-2050 by two times.
  • Thermo Fisher Scientific Holdings, Inc. introduced online 2D-liquid chromatography (LC) systems to provide the highest degree of application adaptability and diversity for multidimensional liquid chromatography in fields including pharmaceutical/biopharmaceutical R&D, food safety, environmental testing, and polymer analysis
  • Report ID: 4590
  • Published Date: Nov 24, 2025
  • Report Format: PDF, PPT
Festive Special Offer
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Frequently Asked Questions (FAQ)

In the year 2026, the industry size of 2D chromatography is evaluated at USD 3.22 billion.

The global 2D chromatography market size was worth around USD 2.93 billion in 2025 and is set to register a CAGR of more than 11.1%, exceeding USD 8.39 billion revenue by 2035.

By 2035, North America is set to secure a 32% share of the 2D Chromatography Market, supported by expanding household heating-oil usage impelled by the growing use of heating oil by households.

Key players in the market include Merck KGaA, Agilent Technologies, Inc., LECO Corporation, Waters Corporation, Shimadzu Corporation, Restek Corporation, SepSolve Analytical Ltd., Danaher Corporation, Bio-Rad Laboratories, Inc., Thermo Fisher Scientific Holdings, Inc.

2D Chromatography Market Report Scope

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