Hydrophobic Interaction Chromatography Market Size & Share, by Products & Services (Resin, Columns, Buffer, Services); Sample (Monoclonal Antibodies, Vaccines); End-user (Pharmaceutical Companies, CROs & CMOs, Research Institutes) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2023-2035

  • Report ID: 5000
  • Published Date: Jun 02, 2023
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2023 - 2035

Hydrophobic Interaction Chromatography Market size is poised to surpass USD 4.61 Billion by 2035, observing nearly 10.5% growth rate from 2023 to 2035. In the year 2022, the industry size of hydrophobic interaction chromatography was USD 1.39 Billion.

The market growth is rising due to growing cases of infectious diseases, such as COVID-19, and higher development of vaccines. In nations around the world, more than thirty vaccines have been approved for general or emergency use. Since host cells can contaminate the final vaccine product during the manufacture of the viral vaccine, HIC is employed to remove the host cell protein, ensuring the purity and safety of the final vaccine formulations.

Rising cases of patent expiration are likely to boost hydrophobic interaction chromatography market. When a drug's patent expires, manufacturers may be forced to design their own purifying technique in order to make generic medications. In this regard, HIC can be viewed as a viable purification tool for medication development by manufacturers.

Hydrophobic Interaction Chromatography Market
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Global Hydrophobic Interaction Chromatography Market: Growth Drivers and Challenges

Growth Drivers

  • Growing Development of Monoclonal Antibodies – At least 570 therapeutic mAbs have been researched in clinical trials by commercial businesses around the world, and 79 therapeutic mAbs have been licensed and are currently on the market by the United States Food and Drug Administration (US FDA). Hydrophobic interaction chromatography is an essential part of the development of Mabs, as they are used for its analysis and final purification.
  • Rising Expenditure on Biopharmaceutical R&D –The increased spending on biopharmaceutical research and development, and production leads to a higher generation of new drugs and treatments. In the developmental stage of these drugs, HIC segregates the target molecules from the complex mixtures and helps them meet the regulatory requirements. In 2021, the 15 major pharmaceutical companies in the United States invested a record around USD 133 billion in R&D, approximately a 44% increase over 2016.
  • Rising Cases of Cancer–HIC is used for the characterization and quality of control of cancer treatment therapeutic proteins. Therefore, the rising cases of cancer are driving the market growth. Cancer is one of the leading causes of death on the globe. Moreover, every year, around 400 000 children are identified as cancer patients.


  • Hydrophobic Interaction Chromatography is Expensive – HIC has various components, such as chromatography column, detectors, and systems, that is costly to acquire and maintain. Moreover, other consumables, including resin and buffers can also put a burden on the overall expense. Therefore, all these expenditures, particularly for a small organization, are likely to hamper the hydrophobic interaction chromatography market growth.
  • Lack of highly qualified technicians and researchers
  • Low adoption of technique in the under-developed countries

Hydrophobic Interaction Chromatography Market: Key Insights

Base Year


Forecast Year



~ 10.5%

Base Year Market Size (2022)

 ~ USD 1.39 Billion

Forecast Year Market Size (2035)

 ~ USD 4.61 Billion

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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Hydrophobic Interaction Chromatography Segmentation

Sample (Monoclonal Antibodies, Vaccines)

The monoclonal antibodies segment is estimated to hold 38% share of the global hydrophobic interaction chromatography market by 2035. There has been a significant increase in cases of cancer, autoimmune diseases, inflammatory disorders, and Alzheimer. All these diseases have increased the demand for monoclonal antibodies and higher approvals of mAB will drive the segment growth. For instance, in 2022, the FDA granted an emergency use authorization (EUA) for bebtelovimab, a novel monoclonal antibody for the treatment of COVID-19. Monoclonal antibodies are present in different isoforms, that have varying hydrophobic properties, HIC helps in separating and identifying these isoforms. This data generated after performing HIC can be used to assess the stability and consistency of the mAB products.

Products & Services (Resin, Columns, Buffer, Services)

Hydrophobic interaction chromatography market from the resin segment is expected to garner a significant share of around 40% in the year 2035. Continuous advancements in HIC resin technology are leading the segment’s growth. The development of improved resin has enhanced the performance characteristics. The advanced properties include better resolution, improved selectivity, enhances stability, higher binding capacities, and others.

Our in-depth analysis of the market includes the following segments:


  • Monoclonal Antibodies
  • Vaccines

         Product & Services

  • Resin
  • Columns
  • Buffer
  • Services

          End User

  • Pharmaceutical Companies
  • CROs & CMOs
  • Research Institutes

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Hydrophobic Interaction Chromatography Industry - Regional Synopsis

North American Market Forecast

The North America hydrophobic interaction chromatography market is projected to be the largest with a share of about 35% by the end of 2035. Growing cases of cancer and autoimmune diseases are driving the market growth. In 2022, the United States recorded around 1,918,030 new cancer cases and nearly 609,360 cancer deaths. Monoclonal antibodies are commonly utilized in cancer therapy. HIC allows for the production of high-purity mAB, which is employed in cancer therapy.

European Market Statistics

The European hydrophobic interaction chromatography market is estimated to be the second largest, registering a share of about 28% by the end of 2035. The presence of the leading biopharma companies leads to the higher discovery of therapies and results in higher demand for the HIC for better output of these drugs. Many of the world's biggest pharmaceutical companies have their base in Europe, including Novartis, Roche, Bayer, Novo Nordisk, AstraZeneca, Sanofi, GSK, and many others.

Research Nester
Hydrophobic Interaction Chromatography Market Size
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Companies Dominating the Global Hydrophobic Interaction Chromatography Landscape

    • Sunresin New Materials Co., Ltd.
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Bio-Rad Laboratories, Inc.
    • Thermo Fisher Scientific
    • The General Electric Company
    • Sartorius AG
    • Tosoh Bioscience, Inc.
    • Sepax Technologies, Inc.
    • Merck KGaA.
    • JNC Corporation
    • Geno Technology Inc.


In The News

  • Sunresin Materials Co., Ltd. announced the launch of highly cross-linked agarose chromatography, SP Seplife FF chromatography resin. It is resin with high chemical stability, low back pressure, and high dynamic loading.
  • Bio-Rad Laboratories, Inc. launched its new CHT prepacked Foresight ProColumns. It is intended to facilitate downstream process-scale chromatography operations at various phases of biological drug research and manufacturing.

Author Credits:  Radhika Gupta, Shivam Bhutani

  • Report ID: 5000
  • Published Date: Jun 02, 2023
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

Rising development of vaccines and higher investment in biopharma industries are the major factors driving the market growth.

The market size of hydrophobic interaction chromatography is anticipated to attain a CAGR of 10.5% over the forecast period, i.e., 2023 – 2035.

: The major players in the market are Bio-Rad Laboratories, Inc., Thermo Fisher Scientific, The General Electric Company, Sartorius AG, Tosoh Bioscience Inc., Sepax Technologies, Inc., Merck KGaA., JNC Corporation, and Geno Technology Inc., and Sunresin New Materials Co.Ltd.

The company profiles are selected based on the revenues generated from the product segment, the geographical presence of the company which determines the revenue generating capacity as well as the new products being launched into the market by the company.

The market is segmented by sample, product & services, end user, and by region.

The monoclonal antibodies segment is anticipated to garner the largest market size by the end of 2035 and display significant growth opportunities.

Lack of trainer forces, and high cost of implementation are estimated to be the growth hindering factors for the market expansion.

The market in the North American region is projected to hold the largest market share by the end of 2035 and provide more business opportunities in the future.
Hydrophobic Interaction Chromatography Market Report Scope

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