Hyaluronidase Market Size & Share, by Source (Animal-Derived, Synthetic, Bio-Engineered); Application (Dermatology, Chemotherapy, Ophthalmology, Plastic Surgery, Cosmetology); Distribution Channel (Hospitals, Retail Pharmacies, Online Pharmacies) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2024-2036

  • Report ID: 5293
  • Published Date: Oct 05, 2023
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2024 - 2036

Hyaluronidase Market size is expected to reach USD 12 billion by the end of 2036, witnessing around CAGR 9% during the forecast period i.e., 2023 – 2036. In the year 2023, the industry size of hyaluronidase was around 1 billion. The growth of this market can be attributed to the account of the increasing prevalence of chronic diseases worldwide. Chronic diseases such as cancer and diabetes can lead to the accumulation of hyaluronic acid in tissues. This can cause a variety of problems, such as pain, inflammation, and swelling. Hyaluronidase can be used to break down hyaluronic acid and retrieve these symptoms. Every year 41 million people die out of chronic disease which is 74% of world’s population. 

Furthermore, increasing technological advancement in the development of hyaluronidase power injections has made them more effective and safer. For instance, the development of recombinant hyaluronidase has reduced the risk of allergic reactions.

Hyaluronidase Market
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Hyaluronidase Sector: Growth Drivers and Challenges

Growth Drivers

  • Escalating Demand for Regenerative Medicines – Regenerative medicine is a field that focuses on the repair and replacement of damaged tissues and organs. Hyaluronidase power injections can be used to prepare cells and tissues for transplantation and to improve the delivery of therapeutic drugs.
  • Growing Government Support for Research and Development – Government all across the globe are expanding their support and encouraging research and development in the field of hyaluronidase. This further is leading to the development of new and innovative applications for this technology. 


  • Competition from Other Minimally Invasive Procedures – Hyaluronidase power injections face competition from other minimally invasive procedures, such as botulinum toxin injections and laser treatments. These procedures may be more affordable and have fewer side effects than hyaluronidase power injections. Therefore, it is expected to limit the market expansion of hyaluronidase in the forecast timeframe.
  • Lack of Awareness about Hyaluronidase is estimated to Restrict its Market Growth in the Upcoming Period.
  • Side Effects Associated with Hyaluronidase is Predicted to Hamper the Market Expansion in the Predicted Period.

Hyaluronidase Market: Key Insights

Base Year


Forecast Year




Base Year Market Size

~USD 1 billion

Forecast Year Market Size

~USD 12 billion

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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Hyaluronidase Segmentation

Source (Animal-Derived Hyaluronidase, Synthetic Hyaluronidase, Bio-Engineered Hyaluronidase)

In terms of source, the animal derived hyaluronidase segment in the hyaluronidase market is estimated to hold the largest market share of 40% by the end of 2036. Most recognized products on the market now use hyaluronidase derived from animals, which has gained widespread acceptance. Currently, producers can create animal-derived hyaluronidase at a lower cost than synthetic or bioengineered hyaluronidase. However, the acceptance of alternate sources is soon anticipated to rise because to the increasing animal rights issues and initiatives. The most popular animal sources are bovine and porcine, which profited from the numerous regulatory licenses they have obtained from organizations like the FDA in the US.    

Application (Dermatology, Chemotherapy, Ophthalmology, Plastic Surgery, Cosmetology)

Based on application, the dermatology segment is estimated to grow notably during the time period between 2024-2036. The need for hyaluronidase power injections in the dermatology industry has expanded because of the rising public demand for non-invasive methods to treat skin rashes, dehydration, redness reduction, fine lines, and aging. The rising rates of skin conditions and their consequences will both have a significant beneficial impact on the dermatological market. Skin problem is one of significant health concern affecting 30-60% of population in Europe, recorded as per a study.

Our in-depth analysis of the global market includes the following segments:




  • Animal-Derived Hyaluronidase
  • Synthetic Hyaluronidase
  • Bio-Engineered Hyaluronidase




  • Dermatology
  • Chemotherapy
  • Ophthalmology
  • Plastic Surgery
  • Cosmetology


     Distribution Channel

  • Hospitals
  • Retail Pharmacies
  • Online Pharmacies

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Hyaluronidase Landscape: Regional Synopsis

North America Market Forecast:

The hyaluronidase market in North America is estimated to account for the largest revenue share of 33% by 2036. The market in this area is anticipated to benefit from the increasing number of vendors offering dermatology and cosmetic treatments such as facial injectables with hyaluronidase power injections. The demand for these items has surged in the area as a result of the government regulators in the area approving a number of hyaluronidase items for use by the populace.

Asia Pacific Market Statistics

In Asia Pacific region, the hyaluronidase market is predicted to grow significantly during the time period between 2024-2036. The primary factor influencing the anticipated expansion in the market for hyaluronidase in the region is the expanding medical tourism sector. India from the APAC region was ranked 10th in the Medical Tourism Index out of 46 countries. The need for hyaluronidase power injections in this area is anticipated to rise as a result of the region's abundance of suppliers that offer the products at lower prices than those in other locations and its less expensive facilities.  

Research Nester
Hyaluronidase Market Size
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Companies Dominating the Hyaluronidase Landscape

    • Sun Pharmaceutical Industries Ltd.
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • PrimaPharm Inc.
    • Valeant Pharmaceuticals
    • Halozyme Therapeutics
    • CooperSurgical Fertility Companies
    • Amphastar Pharmaceuticals Inc.
    •  Shreya Life Science
    • Bausch & Lomb Incorporated
    • Stemcell Technologies Inc.
    • Anika Therapeutics Inc.
    • Alteogen Inc.

In the News

  • Alteogen Inc., a South Korean biotechnology company, announced that the recently completed Tergase clinical trial showed no cases of ADA, including neutralizing antibodies. Tergase is Alteogen's first proprietary product currently undergoing the pharmaceutical approval process by the Korean Ministry of Food and Drug Safety. Tergase is a stand-alone hyaluronidase product that can be used to treat various medical conditions, such as pain relief, edema treatment, and hyaluronic acid filler removal. In particular, compared to  animal-derived hyaluronidase products available on the market, this is a high quality, highly pure product  with very few impurities and has excellent few side effects. As a new recombinant human hyaluronidase, Alteogen hopes Tergase can be applied to new indications not currently  available for existing animal-derived products.
  • Halozyme Therapeutics, Inc. announced in June 2023  that argenx received approval from the U.S. Food and Drug Administration (FDA)  for VYVGART Hytrulo Injection with ENHANZE for subcutaneous use in the treatment of generalized myasthenia gravis in Adult patients positive for anti-acetylcholine receptor antibodies. 

Author Credits:  Radhika Gupta, Shivam Bhutani

  • Report ID: 5293
  • Published Date: Oct 05, 2023
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

The growing prevalence of chronic disease and increasing support by the government on its research and development activities are some of the major factors anticipated to drive the growth of the cell culture consumables market.

The market is anticipated to attain a CAGR of ~9% over the forecast period, i.e., 2024 – 2036.

The major players in the market are Halozyme Therapeutics, CooperSurgical Fertility Companies, Amphastar Pharmaceuticals Inc., Shreya Life Science, Bausch & Lomb Incorporated, Stemcell Technologies Inc., Anika Therapeutics Inc., Alteogen Inc., and others.

The dermatology segment is anticipated to garner the largest market size by the end of 2036 and display significant growth opportunities.

The market in North America is projected to hold the largest market share by the end of 2036 and provide more business opportunities in the future.
Hyaluronidase Market Report Scope

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