Global and Southeast Asia Protein Purification & Isolation Market size is estimated to surpass USD 20.5 Billion by the end of 2035, witnessing around 8.65% CAGR during the forecast period, i.e., 2023-2035. In the year 2022, the industry size of global and southeast Asia protein purification & isolation was USD 6.9 Billion. The growth of the market can be attributed to the increasing desire among researchers and laboratory analysts to prevent contamination during the protein extraction and isolation procedure.
The increased importance of generating novel ligands including protein-based pharmaceutical compounds is one of the primary factors fueling market growth. Furthermore, an increasing need for purification kits in quick screen tests, a move toward advanced technological equipment for protein purification, the development of the proteomics sector, and increasing R&D in medicinal products and biotechnological businesses are expected to drive market growth. Also, Governments are increasing expenditure on R&D and implementing programs to help the pharmaceutical and biotechnology sectors grow. As per the India Brand Equity Foundation (IBEF), over 2,500 biotech enterprises have been founded in the nation. In 2019, the Indian biotechnology sector was worth USD 63 billion.
Growth Drivers
Growing Need for More Accurate Purification Kit- Protein purification and isolation methods are being pushed even further by ongoing technical breakthroughs. Traditional technologies such as agarose beads and other resins are being replaced by magnetic and protein fragments, as well as ligand tagging systems. Furthermore, the growing usage of automated analyzers is likely to increase requirements for protein purification and separation. Thermo Fisher Scientific Inc. (US) introduced the KingFisher Apex Purification System in April 2021, a protein-rich sample purification equipment enabling researchers to separate DNA, proteins, and cells. This technology aids in protein and cell isolation while also providing a highly tailored procedure for the adaptive, reproducible, and rapid creation of samples at no additional expense. It uses automated technologies to provide error-free reports as well as high-quality nucleic acids and proteins. In 25 to 65 minutes, this protein purification system can operate 24 to 96 samples.
Increasing Research & Developmental Activities- Governing bodies are increasingly investing in R&D and undertaking initiatives that promote the development and growth of pharmaceutical and biotechnology markets. For protein purification and isolation solutions, pharmaceutical is a highly lucrative industry owing to the significant investments in the development of biomarker-specific molecules. In the preclinical drug development phase, the precise isolation of proteins with a significant amount of purified substrate is a vital component. On the other hand, technological advancements in the protein purification and isolation process, such as the increasing preference for magnetic and protein beads and ligand tagging systems over traditional methods, such as agarose beads and other resins, coupled with the rising utilization of automated analyzers are anticipated to drive the growth of the global and Southeast Asia protein purification & isolation market. According to a report issued by Research America in January 2022, the projected Pharmaceutical and Health R&D Expenditure in the United States in 2020 was USD 245,127 million, while it was roughly USD 221,438 million in 2019.
Application in the study and assessment of the severe acute respiratory syndrome coronavirus (SARS-CoV-2)- based on a study titled "Recombinant Protein Expression and Purification of N, S1, and RBD of SARS-CoV-2 from Mammalian Cells and Their Potential Applications" published by the National Library of Medicine in September 2021, there is an enormous need for screening and serological resources worldwide, as countries must develop their own methods for the manufacture of superior biomolecules.
Increased investment in the pharmaceutical business- India's pharmaceutical sector is predicted to be worth $65 billion by 2024 and $130 billion by 2030. India is an influential pharmaceutical exporter, with over 200 nations covered by Indian pharmaceutical shipments.
Challenges
High Cost of Instruments and Tools
The high costs of instruments and tools hamper the adoption rate of protein purification and isolation solutions dramatically. Additionally, the difficulties observed in maintaining one size that fits all purification kits of sample preparation in the laboratory, coupled with the factors such as the high costs and problems with scaling up the purification and isolation processes and the doubts about the efficiency of the solutions are some of the factors anticipated to limit the growth of the global and Southeast Asia protein purification & isolation market.
A Scarcity of Qualified Personnel
A reduction in the rate of deployment of new equipment
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Base Year |
2022 |
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Forecast Year |
2023-2035 |
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CAGR |
~8.65% |
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Base Year Market Size (2022) |
~ USD 6.9 Billion |
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Forecast Year Market Size (2035) |
~ USD 20.5 Billion |
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Regional Scope |
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Product (Instruments, Consumables)
The global and southeast Asia protein purification & isolation market has been segmented by product into instruments and consumables. The consumables segment is further divided into kits, reagents, columns, resins, and magnetic beads. The kits segment registered the largest market share of 29.27% along with a value of USD 612.70 million in the year 2019 and is anticipated to reach a value of USD 2293 million by the end of 2035 by growing at a CAGR of 8.60% during the forecast period. Kit is a tool used for the purification and preparation of proteins from tissues or cells and can isolate protein from large samples of tissue or cultured cells. The kits help to prepare whole lysates and specific cellular fractions which is especially important when performing 2D electrophoresis by reducing the complexity and making the analysis much easier. On the other hand, consumables are components that are used along with instruments in protein purification and isolation.
Technology (Ultrafiltration, Precipitation, Chromatography, Electrophoresis, Western Blotting)
The global and southeast Asia protein purification & isolation market is also segmented and analyzed for demand and supply by technology into ultrafiltration, precipitation, chromatography, electrophoresis, western blotting, and others. Amongst these segments, the ultrafiltration segment is expected to garner a significant share of around ~35% in the year 2035. The method of extracting exceedingly tiny particles and dissolved molecules from solutions is known as ultrafiltration. The magnitude of the molecules is the basic basis for separation, albeit the chemical, molecular, or electrostatic characteristics of the sample might impact the permeability of the filter. To be isolated by ultrafiltration, particles must be at least one order of magnitude apart in size and have a molecular mass between 1 and 1000 kDa. Ultrafiltration is commonly employed to separate proteins from buffer ingredients in preparation for buffer swapping, concentration, or desalting.
The benefits of ultrafiltration and the widespread use of ultrafiltration for protein purification and isolation are the primary drivers of segment expansion throughout the predicted period.
Our in-depth analysis of the global market includes the following segments:
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By Product |
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By Technology |
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North American Market Forecast
The market in North America registered the largest market share of 26.14% along with a value of USD 1638.48 million in the year 2019 and is expected to reach a value of USD 6244.4 million by the end of 2035 by growing at a CAGR of 8.72% during the forecast period. The market in the region is thriving on the back of numerous factors, including increasing research in pharmaceutical and biotechnological fields, growing demand for rapid purification kits in the rapid screen test, a paradigm shift towards automated instrumentation for protein purification, and growth of the proteomics market. Additionally, increasing demand for specialized drugs, the presence of a large number of market players, developed research and development infrastructure, and the increasing technological advancements in the proteomics field are some of the additional factors anticipated to drive market growth in the region.
North America's dominant countries are the United States, Mexico, and Canada. Furthermore, owing to the presence of major vendors in the region, the US has contributed to a substantial portion of the market, and an upsurge in biopharmaceutical development of medicines is concurrently propelling market expansion in the projection period.
APAC Market Statistics
The global and Southeast Asia protein purification & isolation market in the Asia Pacific region is expected to grow the fastest over the forecast period. The need for protein purification and isolation solutions is expected to be fueled in this field by activities undertaken by developing-nation administrations such as India and China to enhance medical facilities. Furthermore, these governments are investing in the research and development of novel purification and isolation technologies. The Asia Pacific region is second in terms of dominance due to developing markets for protein purification & isolation market to improve healthcare infrastructure and raise patient knowledge about the accessibility of medical tests and technical solutions. China, Japan, and India are the dominant countries in the Asia Pacific, providing enormous chances for market participants to grow and keep up with trends in order to achieve lucrative results.
Europe Market Forecast
On the other hand, Europe is also expected to account for a major share of the global market over the forecast period. The growing importance of discovering novel ligands, such as protein-based therapeutic compounds, is driving the market's expansion. Furthermore, increasing research in pharmaceuticals and biological technologies fields, growing requirements for swift purification devices in swift screen tests, a paradigm shift toward automatic instrumentation for protein purification, and the development of the proteomics business are projected to stimulate the advancement of the Southeast Asia protein purification & isolation market in the European region.
Author Credits: Radhika Gupta, Shivam Bhutani
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