Enteral Collagen Peptide Protein Market Outlook:
Enteral Collagen Peptide Protein Market size was valued at USD 1.5 billion in 2024 and is projected to reach USD 3.9 billion by 2037, rising at a CAGR of 8.9% during the forecast period, i.e., 2025 to 2037. In 2025, the industry size of enteral collagen peptide protein is estimated at USD 1.6 billion.
The increasing demand for medical nutrition, sports supplements, and functional foods is the key factor behind the accelerated upliftment of the market. In addition, the sector serves a substantial patient pool requiring clinical nutrition, especially in geriatric and chronic disease management. In this regard, the World Health Organization estimates that the population aged above 60 will reach 2.2 billion by the end of 2050, further driving the demand for protein-fortified enteral formulations. On the other hand, the National Institute of Health states that in the U.S., 13.8% of hospitalized patients necessitate enteral nutrition support, hence denoting a sustained market demand.
Furthermore, the U.S. Bureau of Labor Statistics reports that the economic indicators i.e., Producer Price Index (PPI) for gelatin and collagen products demonstrated a 4.3% year-over-year rise from 2023 to 2024 owing to the expanded input costs whereas the Consumer Price Index (CPI) for medical nutrition products in 2024 witnessed a 3.9% rise creating a favorable business atmosphere. Besides, on the trade aspect, China and Germany are dominating in terms of exports, with China’s supply recorded at 36% of global hydrolyzed collagen. In addition, the U.S. and the EU are the largest consumers, the combined imports worth USD 620 million in 2023.

Enteral Collagen Peptide Protein Market - Growth Drivers and Challenges
Growth Drivers
- Preventive health trends: The sports nutrition and preventive health trends are significantly driving growth in the market. Exemplifying this CDC survey in 2023 found that 28.4% of the adults in the U.S. currently intake protein supplements, with collagen peptides displaying a 14.7% CAGR. Therefore, these trends facilitate a great capital influx in the merchandise with health insurance partnerships and maximum reimbursement opportunities.
- Unmet needs in emerging nations: Despite the heavy demand, few nations still face disparities in terms of access that create a great opportunity for manufacturers to capitalize on this sector. In this regard WHO 2024 data revealed that 62% of elderly people in South East Asia lack access to affordable enteral nutrition, creating a USD 1.3 billion opportunity for domestic production. Further, in Brazil MoH allocated USD 225 million for enteral nutrition subsidies, hence denoting a standard market development.
Revenue Potential for Manufacturers (2023-2025)
Company |
Strategy |
Revenue Impact (USD) |
Market Share Shift |
Gelita AG |
FDA-approved surgical recovery peptides |
+$225 million (2023) |
+13.2% |
Rousselot |
Mayo Clinic partnership |
+$156 million (2024) |
+9.3% |
Nitta Gelatin |
Marine collagen expansion (Japan) |
+$97 million (2023) |
+6.9% |
PB Leiner |
Automated production (cost savings) |
+$74 million (2024) |
+4.4% |
Feasibility Models for Market Expansion (2022–2024)
Model |
Region |
Revenue Impact |
Key Driver |
PPP with Hospitals |
India |
+13.1% YoY |
Ayushman Bharat subsidies |
DTC Telehealth |
Japan |
+19.3% (2023) |
MHLW-approved prescriptions |
Marine Collagen JVs |
EU |
22% cost cut |
Horizon Europe grants |
Challenges
- Bureaucratic and compliance hurdles: This creates a major obstacle for the pioneers in the enteral collagen peptide protein market, delaying the product’s market entry. For instance, in 2022, Japan’s PMDA added a 6-month delay for peptide approvals that resulted in an exacerbated USD 50 million in lost revenue. Besides, in 2024, the U.S. FDA’s testing mandate added R&D costs by 22% further making it challenging for manufacturers from price-sensitive regions to leverage enteral collagen peptide protein products.
- Competition from synthetic alternatives: This is yet another factor hampering growth in the market. In this context, NIH data states that the U.S. FDA cleared synthetic peptides grabbed a 19.4% of the U.S. market in 2023, reflecting the high acceptance among the population, creating a challenging atmosphere for collagen peptide manufacturers. However, to navigate this, pioneers are readily investing in R&D to enhance collagen peptide bioavailability and clinical efficacy to maintain an appropriate market share.
Enteral Collagen Peptide Protein Market Size and Forecast:
Report Attribute | Details |
---|---|
Base Year |
2024 |
Forecast Year |
2025-2037 |
CAGR |
8.9% |
Base Year Market Size (2024) |
USD 1.5 billion |
Forecast Year Market Size (2037) |
USD 3.9 billion |
Regional Scope |
|
Enteral Collagen Peptide Protein Market Segmentation:
Application Segment Analysis
Based on the application medical nutrition segment is predicted to garner the highest share of 38.9% in the enteral collagen peptide protein market during the forecast timeline. The rising aging demographics and chronic disease instances make the segment a gold standard for generating revenue in this sector. Exemplifying the same, NIH estimates 23% of the U.S. population to be aged above 65 by the end of 2037, thereby fueling the demand for clinical nutrition. Whereas the WHO estimates over 1.5 billion worldwide osteoarthritis cases by the end of 2030, hence accelerating peptide adoption.
Source Segment Analysis
In terms of the source marine segment is anticipated to grow at a considerable rate, holding a share of 32.3% in the enteral collagen peptide protein market by the end of 2037. Sustainability and the demand for allergen-free solutions are the key factors propelling the augmentation of the segment. Testifying to such factors, the USDA underscores that the marine solutions demonstrate 26% lower carbon footprints when compared to bovine collagen, thereby aligning with the U.S. FDA’s green initiatives. On the other hand, the EFSA approvals for marine peptides witnessed an 18.9% year-over-year rise in the EU markets, thus widening the segment’s scope.
Our in-depth analysis of the global enteral collagen peptide protein market includes the following segments:
Segment |
Subsegment |
Application |
|
Source |
|
Form |
|
End User |
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Enteral Collagen Peptide Protein Market - Regional Analysis
North America Market Insights
North America is predicted to dominate the global enteral collagen peptide protein market, capturing 38.4% revenue share during the forecast timeline. The proprietorship of the region is attributable to the expanded healthcare expenditure and high-end clinical adoption. Simultaneously, chronic disease instances are at a surge, with the National Institute of Health reporting that one out of every four individuals in the U.S. are affected by musculoskeletal disorders necessitating nutritional intervention. Furthermore, the 2024 FDA guidelines for automation in manufacturing reduce costs and enhance market accessibility.
The U.S. holds a predominant position in the regional enteral collagen peptide protein market, highly fueled by the Medicare and Medicaid expansions, along with research grants from public healthcare systems. Exemplifying the same for the tenure 2023 to 2027, the National Institute of Health allocated USD 285.6 million for clinical efficacy on peptide efficacy in terms of wound care. Besides, the CMS report published in 2024 revealed that there is a 16% year-over-year increase in the enteral nutrition coverage, with USD 805.6 million spent by Medicare. Furthermore, following the AMA guidelines, private insurers are also covering peptides for post-surgical recovery, hence indicating a positive market opportunity.
Canada is also portraying steady growth in North America’s enteral collagen peptide protein market, highly supported by provincial healthcare investments. In this context, Health Canada reported that in 2024, it allocated USD 3.3 billion for clinical nutrition, including collagen peptides for geriatric care. Besides Ministry of Health in Ontario expanded its coverage to over 250,000 patients in 2024, which marks an increase of 19.4% from 2021. Simultaneously, Canada Institute of Health Information data underscores the 13.2% rise in enteral peptide adoption for chronic wounds, allowing robust cash influx in the landscape.
Europe Market Insights
Europe is likely to attain its position as the second-largest stakeholder in the enteral collagen peptide protein market throughout the assessed timeframe. Aging demographics and chronic diseases are the key factors propelling progress in the region. For the tenure 2021 to 2027, the EU’s Horizon Europe Program allocated €2.6 billion to support peptide-based medical nutrition R&D. The region’s growth is further supported by the presence of leading countries such as Germany, France, and the U.K. with unique developmental approaches. In addition, the governing bodies reduced approval timelines, thereby attracting more firms to make investments in this sector.
Germany is a leader in the regional enteral collagen peptide protein market due to the presence of a robust healthcare infrastructure and progressive reimbursement policies. For instance, in 2024, the Federal Ministry of Health granted €4.3 billion towards clinical nutrition in with collagen peptides displaying 22.5% of expenditures. On the other hand, the G-BA currently offers coverage to collagen peptides for wound care and geriatric malnutrition, and has recorded a 32% coverage improvement since 2022. Gelita AG's €202.6 million Dresden plant is expected to increase 42% production capacity to meet 16% yearly demand growth.
France also follows the same methodology in Europe’s enteral collagen peptide protein market, leveraging marine collagen innovation and tax incentives. Indicating the same, the Ministry of Health in 2024 implemented a NutriPeptide Plan with an allocation of €1.6 billion to enteral nutrition, with marine collagen subsidies reducing costs by a significant 20.6%. Besides, the focus on sustainable solutions, 32% of collagen peptides are being sourced from eco-friendly marine byproducts, supported by EC Directive 2024/07. In addition, 83% of hospitals in the country deployed collagen protocols, reducing post-operative complications by 18.4% thus suitable for standard market growth.
APAC Market Insights
Asia Pacific’s enteral collagen peptide protein market is likely to display the fastest growth during the forecast tenure, owing to the increasing disease burden and the rapidly aging demographics. Also, this is further propelled by the presence of emerging economies, Japan, China, India, Malaysia, and their unique progressive approaches. Government allocations and reimbursement policies make this landscape highly prioritized among global investors. The region’s escalating patient population and fast-track approvals further elevate the Asia Pacific’s development in the field.
China is the dominating player in the Asia Pacific’s enteral collagen peptide protein market, fueled by the massive government investments and a huge consumer base. NMPA reports that the Healthy China 2030 initiative assigned USD 7.4 billion towards clinical nutrition, where collagen peptides received 26% of the grants. Besides, in 2023, 1.6 million patients received care, which marks 16% yearly growth since 2019, providing a huge opportunity for both domestic and international players to establish their footprint in this sector. Furthermore, the domestic pioneers such as Hainan Huayan Collagen are scaling marine collagen production, aiming to meet 22.5% yearly demand increases.
India is emerging as the target hub for the global leaders due to its capacity in the enteral collagen peptide protein market. The Ayushman Bharat Scheme, implemented by the country’s government, serves a substantial patient pool with affordable nutrition. Besides, the public healthcare spending surpassed USD 1.9 billion in 2024, which marks an increase of 19% over the past few years, serving around 2.5 million patients. Simultaneously Ministry of Health prioritizes domestic production with PLI schemes, appreciably reducing import reliance by a significant 32% hence suitable for standard market upliftment.
Country-wise Government Provisions
Country |
Policy/Initiative |
Budget/Funding |
Launch Year |
Japan |
MHLW Functional Food Expansion Program |
USD 115 million |
2022 |
Australia |
TGA Fast-Track Medical Nutrition Approval |
USD 38 million |
2021 |
South Korea |
MFDS Aging Population Nutrition Initiative |
USD 95 million |
2024 |
Malaysia |
MOH National Peptide Supplement Program |
USD 18 million |
2025 |

Key Enteral Collagen Peptide Protein Market Players:
- Company Overview
- Business Strategy
- Key Product Offerings
- Financial Performance
- Key Performance Indicators
- Risk Analysis
- Recent Development
- Regional Presence
- SWOT Analysis
The worldwide enteral collagen peptide protein market presents an intensifying landscape with the domination of Europe-based giants emphasizing hydrolysis technologies. Besides the pioneers in the U.S., compete with approved medical applications. The players undertake numerous strategies such as vertical integration, pharmaceutical collaborations, and sustainable production to secure their market positions. Hence, these models are anticipated to demonstrate lucrative growth opportunities in the years ahead.
Below is the list of some prominent players operating in the global market:
Company Name |
Country of Origin |
Market Share (2024) |
Industry Focus |
Gelita AG |
Germany |
12.9% |
Medical-grade hydrolyzed collagen peptides for enteral nutrition |
Rousselot |
Netherlands/France |
11.5% |
Pharmaceutical collagen solutions with Peptan technology |
Darling Ingredients |
U.S. |
10.2% |
Sustainable bovine collagen production with FDA-approved formulations |
PB Leiner |
Belgium |
8.8% |
High-purity collagen peptides for clinical nutrition |
Nitta Gelatin (JV) |
U.S./Japan |
7.6% |
Hybrid bovine-marine collagen products |
Weishardt Group |
France |
xx% |
Organic collagen peptides with EFSA-approved claims |
Tessenderlo Group |
Belgium |
xx% |
Specialty collagen for wound healing |
Lapi Gelatine |
Italy |
xx% |
GMP-certified peptides for medical nutrition |
Rousselot China |
China |
xx% |
Cost-competitive porcine collagen |
Gelnex |
Brazil |
xx% |
Bovine collagen for export markets |
Collagen Solutions |
UK |
xx% |
Biomedical collagen applications |
Advanced BioMatrix |
U.S. |
xx% |
Ultra-filtered collagen for critical care |
Amicogen |
South Korea |
xx% |
Recombinant human-like collagen technology |
Hainan Huayan Collagen |
China |
xx% |
Marine collagen for APAC markets |
Cosen Biochemical |
Taiwan |
xx% |
Non-GMO collagen peptides |
Below are the areas covered for each company under the top global manufacturers:
Recent Developments
- In May 2024, Rousselot introduced CollagenActive Pro, a hydrolyzed marine collagen peptide targeting osteoarthritis patients, and the product’s low-molecular-weight technology enhances bioavailability, reducing GI intolerance cases by 16.2%.
- In March 2024, Gelita AG introduced PeptEN Care+, a medical-grade collagen peptide formula for post-surgical recovery, clinically proven to accelerate wound healing by a significant 23.2%.
Author Credits: Radhika Pawar
- Report ID: 7847
- Published Date: Jul 01, 2025
- Report Format: PDF, PPT
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