Global Synthetic Bone Graft Substitutes Market
- Introduction
- Market definition
- Assumptions
- Market Segmentation
- Research Methodology
- Variables (Dependent and Independent)
- Multi Factor Based Sensitivity Model
- Executive Summary- Global Synthetic Bone Graft Substitutes Market
- COVID-19 Impact Analysis
- Market Dynamics
- Drivers
- Challenges
- Opportunities
- Threats
- Regulatory Landscape
- Industry Risk Analysis
- Clinical Trial Analysis
- Analysis on the Bone Graft Substitute Manufacturers
- Assessment of End Users of Synthetic Bone Graft Substitutes
- Average Pricing Analysis
- Global Synthetic Bone Graft Substitutes Market Outlook
- Market Size and Forecast, 2019-2028
- By Value (USD Million)
- By Volume (Thousand Units)
- Market Segmentation by:
- Material
- Ceramics
- Hydroxyapatite
- TCP
- Calcium Sulfate
- Bi-Phasic Calcium Phosphate
- Bioactive Glass
- Others
- Composites
- Polymers
- Ceramics
- Application
- Spinal Fusion
- Hip Surgery
- Knee Surgery
- Shoulder Surgery
- Upper Limb Surgery
- Lower Limb Surgery
- Craniomaxillofacial
- Hand and Food Surgery
- Dental Bone Grafting
- Other Surgeries
- Material
- Market Size and Forecast, 2019-2028
- North America Synthetic Bone Graft Substitutes Market Outlook
- Market Size and Forecast, 2019-2028
- By Value (USD Million)
- By Volume (Thousand Units)
- Market Segmentation by:
- Material
- Application
- Country
- Market Size and Forecast, 2019-2028
- Europe Synthetic Bone Graft Substitutes Market Outlook
- Market Size and Forecast, 2019-2028
- By Value (USD Million)
- By Volume (Thousand Units)
- Market Segmentation by:
- Material
- Application
- Country
- Market Size and Forecast, 2019-2028
- Asia Pacific Synthetic Bone Graft Substitutes Market Outlook
- Market Size and Forecast, 2019-2028
- By Value (USD Million)
- By Volume (Thousand Units)
- Market Segmentation by:
- Material
- Application
- Country
- Market Size and Forecast, 2019-2028
- Latin America Synthetic Bone Graft Substitutes Market Outlook
- Market Size and Forecast, 2019-2028
- By Value (USD Million)
- By Volume (Thousand Units)
- Market Segmentation by:
- Material
- Application
- Country
- Market Size and Forecast, 2019-2028
- Middle East and Africa Synthetic Bone Graft Substitutes Market Outlook
- Market Size and Forecast, 2019-2028
- By Value (USD Million)
- By Volume (Thousand Units)
- Market Segmentation by:
- Material
- Application
- Country
- Market Size and Forecast, 2019-2028
- Competitive Landscape, 2019-2028
- Arthrex, Inc.
- Baxter International, Inc.
- DePuy Synthes Companies
- Medtronic
- Wright Medical Group N.V.
- Biomatlante
- Stryker
- Zimmer Biomet
- Kuros Bioscience
- Bioventus LLC
Global Synthetic Bone Graft Substitutes Market Size, Forecast, and Trend Highlights Over 2025-2037
Synthetic Bone Graft Substitutes Market size was valued at USD 1.3 billion in 2024 and is projected to reach USD 2.9 billion by the end of 2037, rising at a CAGR of 7.9% during the forecast period, i.e., 2025-2037. In 2025, the industry size of synthetic bone graft substitutes is estimated at USD 1.4 billion.
The upliftment of the synthetic bone graft substitutes market highly relies upon the increasing volume of orthopedic surgeries, innovations in biomaterials, and the growing burden of bone-related disorders. Besides, the patient pool necessitating synthetic bone graft substitutes is significantly influenced by the increasing instances of trauma, osteoporosis, and orthopedic surgeries. In this regard, as per a WHO report published in 2023, musculoskeletal conditions are affecting more than 1.6 billion people across all nations, with osteoporosis reporting above 8.8 million fractures in a year. This heightened consumer base is evidence of an increased demand for synthetic bone graft substitutes.
Moreover, at the supply front, the market involves sourcing of raw materials such as hydroxyapatite, tricalcium phosphate, which are primarily drawn from chemical manufacturers. In this regard U.S. Geological Survey report in 2023 states that China is the major producer of more than 70% of hydroxyapatite exceptionally impacting the supply stability. Besides the trade data, which indicates that the U.S. marks its presence with USD 320 million worth of imports of bone graft materials in a year, critically from Germany and Switzerland, similarly, exports reached USD 180 million in finished products, thus denoting a positive market outlook.
Synthetic Bone Graft Substitutes Sector: Growth Drivers and Challenges
Growth Drivers
- Advancements in synthetic substitutes: This is one of the crucial factors driving business in the synthetic bone graft substitutes market. As the innovations progress, the upliftment of the market also expands with constant efforts from major firms. In this regard, Biocomposites in 2024 acquired a minority stake in Renovos Biologics, aiming to advance the development of Renovite BMP-2, which is a synthetic nanoclay bone fusion gel. This collaboration appreciably enhances the product portfolio, reflecting a positive market focus to act as a solution for unmet medical needs.
- Supportive medical policies: The market is remarkably influenced by favorable healthcare polices and government-backed medical expenditure. In this regard, in 2023, it is reported that the U.S. Medicare spending for bone graft substitutes reached nearly USD 1.3 billion, which highlights the growing adoption in terms of orthopedic procedures. Besides, the U.S. FDA extends its support with breakthrough device designation, which was recently granted to Renovos' bone graft gel, encouraging the global players to invest in the sector, thereby contributing to market acceleration.
Manufacturer Strategies Shaping the Synthetic Bone Graft Substitutes Market
The presence of leading global manufacturers is shaping the market with distinct tactical strategies. Key players are undertaking product innovation, acquisitions, and geographic expansions with a collective aim of strengthening their market positions. For instance, in 2023, Medtronic announced the launch of Infuse Bone Graft, comprising advanced osteoinductive properties that captured a substantial 14% increased market share by generating USD 320.4 million, thus reflecting an increased adoption of advanced bone graft substitutes. Similarly, government initiatives and growing investments also create a prolific opportunity for the market to expand more.
Revenue Opportunities for Manufacturers
|
Strategy |
Company |
Revenue Impact |
Market Expansion |
|
Osteoinductive graft launch |
Medtronic |
$320.4M (2023) |
+14% spinal fusion |
|
Biodegradable graft acquisition |
Stryker |
$275.6M (2024) |
+26% ASC segment |
|
3D-printed graft adoption |
Zimmer Biomet |
$200M (2024) |
+10% EU market |
|
Outpatient reimbursement |
Industry-wide |
$754M (2025E) |
CMS rule-driven |
|
APAC market penetration |
Smith+Nephew |
$154M (2023) |
+17% India sales |
Feasible Expansion Models Shaping the Synthetic Bone Graft Substitute Market
The market is witnessing growth with the presence of localized manufacturing, tactical partnerships, and value-based procurement models, as they boost accessibility. In this regard World Health Organization reports that in India, collaborations between multinational suppliers and public healthcare facilities remarkably increased the revenue by 15% from 2022 to 2024, with a focus on affordable graft substitutes. Meanwhile, BMG states that in Germany, the focus on outpatient reimbursement policies bolstered the adoption by 18.5%, which also generated €210.6 million in terms of additional revenue, thus readily contributing to the market progression.
Feasibility Models for Market Expansion (2022–2024)
|
Model |
Region |
Revenue Impact |
Key Driver |
|
Hospital Partnerships |
India |
+15% (2022–2024) |
Govt.-subsidized procurement |
|
Outpatient Reimbursement |
Germany |
€210.6M (2023) |
ASC coverage expansion |
|
Tiered Pricing |
Brazil |
+23% adoption |
Affordability initiatives |
|
Medicare Policy Shifts |
USA |
$582M (2025E) |
CMS outpatient coverage |
Challenge
- High manufacturing and development costs: The high costs associated with the production of synthetic bone graft substitutes act as a major restraint for the market to capture an optimum manufacturing base. The process comprises recombinant DNA technology and extensive quality control measures that makes it challenging for manufacturers involved in the market. Furthermore, the expenses associated with clinical trials and regulatory approvals further block accessibility, particularly in price-sensitive regions.
Synthetic Bone Graft Substitutes Market: Key Insights
| Report Attribute | Details |
|---|---|
|
Base Year |
2024 |
|
Forecast Year |
2025-2037 |
|
CAGR |
7.9% |
|
Base Year Market Size (2024) |
USD 1.3 billion |
|
Forecast Year Market Size (2037) |
USD 1.3 billion |
|
Regional Scope |
|
Synthetic Bone Graft Substitutes Segmentation
Application (Spinal Fusion, Joint Reconstruction, Dental Bone Grafting, Craniomaxillofacial)
Based on application, the spinal fusion segment is expected to garner the highest share of 52.6% in the synthetic bone graft substitutes market by the end of 2037. The dominance of the segment is attributable to the extended demand among the aging population and reimbursement policies. In this regard CDC in 2025 expects more than 15 million osteoporosis cases in the U.S., which significantly necessitates the advanced spinal fusion equipment. Besides the improved outpatient reimbursement policies, expanding access and innovative bioactive formulations are reported to lower the recovery time by 42%, thus allowing a larger population to contribute to the segment’s dominance.
Material (Ceramics, Polymers, Composites, Demineralized Bone Matrix)
Based on the material, the ceramics segment is projected to hold a lucrative share of 46.7% in the synthetic bone graft substitutes market during the forecast period. The growth in the segment is subject to its superior nature, i.e., utilizing hydroxyapatite ceramics is known to enhance biocompatibility and osteoconductivity of the material. Meanwhile, the U.S. FDA reports that approved ceramic grafts demonstrate 92% fusion rates in terms of spinal surgeries, making it a preferable factor for adoption. Furthermore, this growing adoption of ceramics dental procedures led to a CAGR rise of 25.6% as reported by NIH, thus another driver for the segment’s adoption.
Our in-depth analysis of the synthetic bone graft substitutes market includes the following segments:
|
Application |
|
|
Material |
|
|
End User |
|
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Customize this ReportSynthetic Bone Graft Substitutes Industry - Regional Synopsis
North America Market Analysis
The North America synthetic bone graft substitutes market is set to account for more than 48.5% of the global market share by the end of 2037. The key hallmark of the regional market’s dominance is the high osteoporosis prevalence, coupled with the Medicare expansion, i.e., USD 1.2 billion in terms of outpatient synthetic bone grafts. Besides, HHS in 2023 reports that the dominance of ambulatory surgical centres, estimated to be 30.5% of procedures by 2027, is another major factor driving business in the sector. NIH extended its support with a funding of USD 482 million for bioresorbable materials, drawing the interest of major firms to invest in availing improved patient outcomes.
Canada is a major player in the North America market, owing to an estimated 7.1% CAGR influenced by public and private healthcare systems. Members in Innovative Medicines Canada invested USD 152 million in research and development, while BC’s surgical backlog reduction increased graft use by 20%, reflecting the prolonged adoption. Besides, the market is further driven by a surge in fracture volume that is 500,00 with 23% increased adoption from 2023 to 2024 as stated by CIHI. Furthermore, a tender by Alberta in 2024 focused on affordable ceramic grafts to reduce import reliance by 13%, thus denoting a positive market development.
APAC Market Statistics
Asia Pacific synthetic bone graft substitutes market is anticipated to witness the fastest growth with a share of 18.4%, growing at a CAGR of 9.3% during the forecast timeline. The regional development is facilitated by the presence of key countries and their developmental tendency. Japan offers its support with the rising number of aging populations, similarly, China dominates with USD 1.3 billion worth of ceramic production. Besides, South Korea is contributing with 3D-printed grafts, with more than 14% of procedures utilizing bioresorbable materials. Hence, these factors appreciably contribute to the market expansion, bolstering growth in Asia Pacific.
There is a huge opportunity for India's market, holding 15.5% of the share in the Asia Pacific market. Key factors driving business in the country include heightened bone graft demand, with the presence of 1.3 million patients in a year, as reported by ICMR. Additionally, the government healthcare expenditure of USD 1.9 billion with 18.2% CAGR is another exceptional fueling factor in the country. Besides, the trends such as Make in India grafts foster a favourable business environment in India, positioning it as a key player in the global market.
Companies Dominating the Synthetic Bone Graft Substitutes Landscape
- Company Overview
- Business Strategy
- Key Product Offerings
- Financial Performance
- Key Performance Indicators
- Risk Analysis
- Recent Development
- Regional Presence
- SWOT Analysis
There is a prominent visibility for the market due to the presence of key organizations with a collective aim of capturing a high market share. The market presents itself as a highly consolidated form, with Medtronic, Stryker, and Zimmer Biomet controlling 61% of global revenue. In this regard, NIH states that Stryker’s 3D-printed Tritanium grafts reduced revision rates by 30%. Similarly, in 2023, Zimmer Biomet acquired Embody, which strengthened its collagen graft portfolio, reflecting positive market adoption. Focus on affordable healthcare and collaborations with regulatory frameworks further strengthens the global market landscape.
Below is the list of some prominent players operating in the global market:
|
Company Name |
Country |
Market Share |
Industry Focus |
|
Medtronic plc |
USA |
24% |
Spinal fusion grafts (Infuse Bone Graft) |
|
Stryker Corporation |
USA |
20% |
Biodegradable & 3D-printed grafts |
|
Zimmer Biomet Holdings |
USA |
17% |
Ceramic & composite grafts |
|
Baxter International |
USA |
10% |
Bioresorbable synthetic grafts |
|
Smith+Nephew |
UK |
9% |
Trauma & orthopedic bone grafts |
|
Johnson & Johnson |
USA |
xx% |
Allografts & synthetic hybrids |
|
Olympus Corporation |
Japan |
xx% |
Hydroxyapatite-based grafts |
|
NuVasive, Inc. |
USA |
xx% |
Minimally invasive spinal grafts |
|
Wright Medical Group |
USA |
xx% |
Extremity-specific grafts |
|
Orthofix Medical |
USA |
xx% |
Bone growth stimulators + grafts |
|
DJO Global (Enovis) |
USA |
xx% |
Trauma-focused synthetic grafts |
|
Cerapedics |
USA |
xx% |
P-15 peptide-coated grafts |
|
Biocomposites Ltd |
UK |
xx% |
Antibiotic-loaded grafts |
|
Graftys |
France |
xx% |
Injectable calcium phosphate grafts |
|
Xtant Medical |
USA |
xx% |
Demineralized bone matrices (DBM) |
|
Amedica Corporation |
USA |
xx% |
Silicon nitride ceramics |
|
Surgival |
India |
xx% |
Low-cost ceramic grafts |
|
Osseon LLC |
USA |
xx% |
Vertebral augmentation grafts |
|
Bioventus LLC |
USA |
xx% |
Osteogenic stimulant grafts |
|
Osteopore International |
Australia |
xx% |
3D-printed bioresorbable grafts |
Below are the areas covered for each company under the top 15 global manufacturers:
Recent Developments
- In June 2024, Medtronic plc launched Infuse Bone Graft Next-Gen, which is an improved osteoinductive synthetic graft with 30% faster fusion rates when compared to previous versions.
- In March 2024, Stryker Corporation launched Ceramicore Flex, which is the first U.S. FDA-approved moldable ceramic graft for complex joint reconstructions.
Author Credits: Radhika Pawar
- Report ID: 2850
- Published Date: Jun 03, 2025
- Report Format: PDF, PPT
