Opioid Antagonist Market Size & Share, by Drug Type (Buprenorphine, Naltrexone, Bunavail); End User (Hospitals, Private Clinics) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2024-2036

  • Report ID: 3179
  • Published Date: Jan 05, 2024
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2024-2036

Opioid Antagonist Market size is expected to reach USD 15 Billion by the end of 2036, growing at a CAGR of 13% during the forecast period, i.e., 2024-2036. In the year 2023, the industry size of opioid antagonists was over USD 3 Billion. Ongoing research and development efforts within the pharmaceutical industry have been dedicated to enhancing the usability and effectiveness of opioid antagonists, particularly in addressing opioid overdoses. One notable advancement involves the evolution of formulations and delivery methods, exemplified by the creation of nasal sprays and auto-injectors specifically designed for naloxone administration. Estimates indicate that the rate of naloxone administrations rose by almost 75%, from 573 to 1004 per 100,000 EMS incidents. This increase is consistent with a 79% rise in the age-adjusted opioid death rate.

Further, The expansion of opioid antagonist applications beyond immediate overdose reversal has significantly impacted market growth. Naltrexone, originally recognized for its role in blocking opioid receptors, has diversified its application, particularly in addressing addiction. Its effectiveness in preventing relapse among individuals grappling with opioid or alcohol dependence has broadened its market potential. Injectable naltrexone was used in 13% of medical programs for Alcohol Use Disorder Treatment , and 3% of programs for opioid use disorder, according to Research Nester Analysts' analysis.

Opioid Antagonist Market
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Opioid Antagonists Sector: Growth Drivers and Challenges

Growth Drivers

  • Increased Advancement in Formulation and Delivery - Ongoing research and development have led to advancements in formulations and delivery methods for opioid antagonists. For instance, the development of nasal sprays and auto-injectors for naloxone has made administration easier, especially for non-medical personnel.
  • Public Health Initiatives - Various public health initiatives, including harm reduction strategies, needle exchange programs, and addiction treatment centers, have contributed to the demand for opioid antagonists as a crucial component of addressing the opioid crisis. To effectively combat the opioid epidemic, public health policies must address both the supply and demand for opioids. For example, an increase in the number of prescriptions for opioid analgesics is linked to an increase in the number of fatal overdoses. On the other hand, increased availability of opioid antagonist therapy is necessary to reduce the demands resulting from opioid use disorders. Oregon's multimodal strategies for addressing opioid abuse and misuse resulted in a 20% decrease in opioid prescriptions as well as a 30% drop in the rate of opioid overdose deaths.
  • Increased Awareness and Education - Efforts to raise awareness about opioid overdose risks and the availability of antagonist drugs have driven market growth. Education campaigns targeting both healthcare professionals and the public emphasize the importance of timely intervention using these antagonists.


  • Affordability & Accessibility- One of the primary challenges is ensuring widespread access to opioid antagonists. Affordability and availability issues can limit accessibility, particularly in regions with limited healthcare resources or areas where these drugs may not be readily accessible.
  • Regulatory barriers leading to hindrances in Formulation.
  •  Chance of delayed administration on encounter with highly potent opioid leading to obstruction in achieving successful outcome in some cases.

Opioid Antagonist Market: Key Insights

Base Year


Forecast Year



~ 13%

Base Year Market Size (2023)

~ USD 3 Billion

Forecast Year Market Size (2036)

~ USD 15Billion

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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Opioid Antagonist Segmentation

Drug Type (Buprenorphine, Naltrexone, Bunavail)

The buprenorphine segment is estimated to hold 52% share of the global opioid antagonist market by 2036. Primarily owing to its excellent clinical profile. In 2020, an estimated 1.7 million individuals reported taking buprenorphine as directed by doctor. The drug has great efficiency in managing addiction, with low potential for abuse as well as relatively mild adverse effects and its favorable formulary coverage are some of the factors that can be attributed to the high adoption of this drug.

End User (Hospitals, Private Clinics)

The hospital segment in the opioid antagonist market is anticipated to garner significant growth during the forecast period, owing to the increasing patient pool for opium and alcohol dependency. Moreover, the critical condition of the individual addicted to drugs, and the need for specific treatment is estimated to boost the segment’s growth.

Our in-depth analysis of the global market includes the following segments:

Drug Type

  • Buprenorphine
  • Naltrexone
  •  Bunavail

End User

  • Hospitals
  •  Private Clinics

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Opioid Antagonist Industry - Regional Synopsis

North American Market Forecast

North American opioid antagonist market is estimated to account for 38 % of the revenue share by 2036. The region has emerged as a significant producer of Naloxone, a primary antagonist used for reversing opioid overdoses which has become more accessible through governmental initiatives, community distribution programs, and increased awareness campaigns. The region's high prevalence of opioid addiction and overdose deaths has prompted regulatory bodies to streamline approval processes for opioid antagonists, fostering a competitive market landscape. Between 2020 and 2021, there was a more than 16% rise in the number of drug overdose deaths. Opioids accounted for more than 75% of the roughly 107,000 drug overdose deaths in 2021. Pharmaceutical companies have expanded research and development efforts, focusing on innovative formulations such as nasal sprays and auto-injectors to enhance ease of use in emergencies.

APAC Market Statistics

Asia Pacific opioid antagonist market is slated to hold a significant revenue share during the forecast period. The region’s market reflects a diverse landscape shaped by varying degrees of opioid misuse and regulatory environments across countries. While countries like Australia and New Zealand have established robust programs promoting naloxone distribution to combat opioid overdoses, other nations within the region face challenges in acknowledging and addressing opioid abuse. Cultural stigma, limited healthcare infrastructure, and differing levels of awareness contribute to disparities in opioid antagonist adoption.

Research Nester
Opioid Antagonist Market size
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Companies Dominating the Opioid Antagonist Landscape

    • Indivior PLC 
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • •Regional Presence
      • SWOT Analysis
    • Alkermes.
    • Titan Pharmaceuticals, Inc.
    • Hikma Pharmaceuticals PLC
    • Orexo AB 
    • Camurus AB
    • Acura Pharmaceuticals. 
    • Collegium Pharmaceutical          
    • AstraZeneca
    • Viatris Inc.
    • Catalent, Inc


In The News

  • A commercial supply agreement has been signed by Harm Reduction Therapeutics, a 501(c)(3) non-profit pharmaceutical company whose mission is to prevent opioid overdose deaths by making affordable naloxone available to everyone, and Catalent, the global leader in enabling the development and supply of better treatments for patients. As per the agreement, Catalent will produce RiViveTM (3.0 mg) naloxone nasal spray from Harm Reduction Therapeutics for the urgent treatment of confirmed or suspected opioid overdoses.
  • The U.S. Food and Drug Administration ("FDA") has approved Titan Pharmaceuticals, Inc.'s application for an Investigational New Drug ("IND") study of its subdermal formulation of nalmefene, an opioid antagonist, for up to six months or longer. The purpose of the formulation is to prevent relapse in adults with opioid use disorder ("OUD") after they have completed opioid detoxification.

Author Credits:  Radhika Gupta, Shivam Bhutani

  • Report ID: 3179
  • Published Date: Jan 05, 2024
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

Increased investments in healthcare, rising awareness, and increase in public health initiatives are some of the major growth drivers for the opioid antagonist market.

The market size of opioid antagonists is anticipated to attain a CAGR of 13% over the forecast period, i.e., 2024-2036.

The major players in the market are Alkermes., Titan Pharmaceuticals, Inc., Hikma Pharmaceuticals PLC, Orexo AB, Camurus AB, Acura Pharmaceuticals., Collegium Pharmaceutical, AstraZeneca, Viatris Inc., Catalent, and others.

The Buprenorphine segment is anticipated to garner the largest market size by the end of 2036 and display significant growth opportunities.

The market in the North American region is projected to hold the largest market share by the end of 2036 and provide more business opportunities in the future.
Opioid Antagonist Market Report Scope

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