Methotrexate Market Analysis

  • Report ID: 6872
  • Published Date: Sep 18, 2025
  • Report Format: PDF, PPT

Methotrexate Market Segmentation:

Application Segment Analysis

The cancer treatment segment is likely to capture methotrexate market share of over 54.3% by 2035. The increasing cases of cancer are pushing the demand for methotrexate drugs for effective treatment. The World Health Organization (WHO) reveals that around 20 million new cancer cases were diagnosed in 2022. Also, the same source estimates that one in five individuals experience cancer growth in their lifetime. Manufacturers’ continuous focus on innovations is leading to the development of advanced and effective anti-cancer methotrexate solutions. For instance, in August 2024, STAQ Pharma announced the expansion of its oncology portfolio starting with methotrexate. The methotrexate solution is widely used for the treatment of pediatric cancer patients.

Formulation Segment Analysis

The tablet segment is expected to hold a dominating methotrexate market share throughout the projected period. Convenience and accurate dosage are prime factors driving the sales of methotrexate tablets. The pediatric and older patient demographics find tablets a more convenient form of administration than injections. The quick effect and cost-effectiveness are other aspects augmenting the demand for methotrexate tablets. Considering these drivers, manufacturers are more concentrated on the development of methotrexate tablets than other formulations. For instance, in August 2024, Elite Pharmaceuticals, Inc. announced the introduction of generic methotrexate sodium 2.5 mg tablets. These tablets are used for acute lymphoblastic leukemia treatment among adults.

Our in-depth analysis of the global methotrexate market includes the following segments:

Application

  • Cancer Treatment
  • Autoimmune Diseases
  • Psoriasis

Formulation

  • Tablet
  • Injection
  • Liquid

Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

End use

  • Hospitals
  • Specialty Clinics
  • Homecare

Browse key industry insights with market data tables & charts from the report:

Frequently Asked Questions (FAQ)

In the year 2026, the industry size of methotrexate is assessed at USD 1.24 billion.

The global methotrexate market size was valued at over USD 1.19 billion in 2025 and is expected to expand at a CAGR of over 4.7%, surpassing USD 1.88 billion revenue by 2035.

North America methotrexate market will account for 33.70% share by 2035, driven by presence of advanced healthcare facilities and rising prevalence of autoimmune diseases.

Key players in the market include Pfenex, Inc., Zydus Lifesciences, Alvogen, Teva Pharmaceutical Industries, Bristol-Myers Squibb, and Mylan N.V.
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