Liquid Phase Peptide Synthesis Market Trends

  • Report ID: 3221
  • Published Date: Jan 03, 2025
  • Report Format: PDF, PPT

Liquid Phase Peptide Synthesis Market Trends

Growth Drivers

  • Advancement in Technology – Continuous Advancement in Liquid-phase synthesis methods, such as automated peptide synthesizers and novel coupling chemistries, enhance efficiency and scalability, thereby driving the market’s growth.
  • Expanding Applications- Diversification of peptide synthesis  applications beyond pharmaceuticals, including diagnostics, cosmetics, and research purposes, broadens the market scope and drives growth.
  • Rising Research & Development Activities- Expanded research activities in pharmaceuticals and biotechnology, focusing on developing new peptide-based drugs, stimulate the demand for liquid-phase peptide techniques. For instance, it is reported that  one-pot liquid phase peptide synthesis process that involves adding amino acids to a "nanostar" support iteratively and using organic solvent nanofiltration (OSN) to isolate the developing peptide at the end of each synthesis cycle.This made it possible to synthesize peptides more effectively while keeping all of the advantages of liquid phase synthesis. First, enkephalin-like model penta- and decapeptides were synthesized, followed by octreotate amide, and ultimately octreotate, in order to verify PEPSTAR. In comparison to vendor-produced samples from solid phase synthesis, the crude purities compared satisfactorily.
  • Government Initiatives- Supportive regulatory policies and funding initiatives by the government to promote peptide-based drug development encourage market growth by fostering innovation and investment in Liquid-phase peptide synthesis technology.

Challenges

  • Complexity in sequence design- peptide synthesis can be complex due to the diversity of peptide sequences desired. Designing and optimizing sequences for desired properties can be challenging.
  • Liquid peptide synthesis can be expensive to plot a large-scale plant.
  • Different amino acids have varying reactivity and compatibility, making it challenging to find suitable reaction conditions for diverse sequences without side reactions or impurities.

Liquid Phase Peptide Synthesis Market: Key Insights

The global liquid phase peptide synthesis market is estimated to grow with a moderate CAGR during the forecast period, i.e., 2022-2030. The extensive deployment of liquid phase peptide synthesis in large-scale industries owing to its capability of producing a large number of high-quality peptides, are expected to fuel the growth of this market. Liquid phase peptide synthesis was the first method to be used for the generation of peptides in-vitro and is still commonly utilized for large-scale peptide synthesis required in end-user industries. It helps in performing convergent peptide synthesis in which separate peptides are synthesized and then are attached together to create larger peptides, which is why it is abundantly used for large-scale production of peptides. The growth of the market can also be attributed to factors such as the increasing use of peptides in pharmaceutical drug development, and treatment of various lifestyle disorders, such as, diabetes and obesity. According to the data collected from International Diabetes Federation, it is estimated that around 463 million people globally had diabetes in 2019, and by 2045, the count is projected to reach 700 million. Peptides have diverse biological characteristics such as high biological activity, high specificity & ample chemical space, relative ease of synthesis, easy availability, and low toxicity, which are further estimated to boost the market growth.

Global-Healthcare-Expenditure-per-Capita

According to the statistics by the World Health Organization, the global per capita healthcare expenditure amounted to USD 1,064.741 in the year 2017. The worldwide healthcare expenditure per person grew from USD 864.313 in 2008 to USD 1,110.841 in 2018, where the U.S. is the top country that amounted to healthcare expenditure of USD 10, 623.85 per capita in 2018. As of 2018, the domestic general government healthcare spending in the U.S. was USD 5355.79, which grew from USD 3515.82 in 2008. These are some of the factors responsible for market growth over the past few years. Moreover, as per the projections by the Centers for Medicare & Medicaid Services (CMS), the estimated average annual percent change related to National Health Expenditures (NHE) in the U.S. was 5.2% in 2020 as compared to 2019 (4.5%). Furthermore, the National Health Expenditures are projected to reach USD 6,192.5 Billion in 2028, where the per capita expenditure is estimated to touch USD 17,611 in the same year. These are notable indicators that are anticipated to create lucrative business opportunities in upcoming years.

Base Year

2024

Forecast Year

2025-2037

CAGR

10.1%

Base Year Market Size (2024)

USD 5.51 billion

Forecast Year Market Size (2037)

USD 19.25 billion

Regional Scope

  • North America (U.S., and Canada)
  • Asia Pacific (Japan, China, India, Indonesia, Malaysia, Australia, South Korea, Rest of Asia Pacific)
  • Europe (UK, Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Latin America (Mexico, Argentina, Brazil, Rest of Latin America)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)

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Author Credits:  Radhika Pawar


  • Report ID: 3221
  • Published Date: Jan 03, 2025
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

In the year 2025, the industry size of liquid phase peptide synthesis is estimated at USD 5.98 billion.

The liquid phase peptide synthesis market size was over USD 5.51 billion in 2024 and is poised to exceed USD 19.25 billion by 2037, witnessing over 10.1% CAGR during the forecast period i.e., between 2025-2037. Growing demand for peptide-based therapeutics, expanding applications, research and development, and supportive government policies will boost the market growth.

North America industry is predicted to dominate majority revenue share of 42% by 2037, fueled by robust research and development activities, the region witnesses extensive utilization of peptides in drug discovery and development by pharmaceutical giants and biotechnology firms.

The major players in the market are CEM Corporation, Bachem AG, CSBio, Biotage, AnaSpec, ZenBio, Inc., Thermo Fisher Scientific Inc., GenScript, PolyPeptide Group, Sosei Group Corporation, Tokyo Mirai Style Co., Ltd., and others.
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