Liquid Phase Peptide Synthesis Market Size & Share, by End-User (Pharmaceutical& Biotechnology Industry, Contract Development & Manufacturing organizations, Academic & Research Institutes); Application (Therapeutics, Diagnostics, Research Purposes, cosmetics, Food) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2024-2036

  • Report ID: 3221
  • Published Date: Jan 05, 2024
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2024-2036

Liquid Phase Peptide Synthesis Market size is poised to reach USD  15 Billion by the end of 2036, growing at a CAGR of 10% during the forecast period, i.e., 2024-2036. In the year 2023, the industry size of liquid phase peptide synthesis was over USD 5 Billion. Growing Demand for peptide-based therapeutics due to their effectiveness in treating various diseases like cancer, metabolic disorders, and hormonal deficiencies fuels the LPPS market. Cancer is one of the leading causes of death globally, Current cancer treatment regimens often cause significant adverse side effects and fall short of effectively eliminating advanced disease. Because of the diverse functions that peptides offer, this nonviral carrier has rapidly gained exposure and popularity as a prospective delivery vehicle. In 2020, there were about 18.1 million cases of cancer worldwide.

Moreover, liquid-phase synthesis was the original method for creating peptides, numerous studies have looked into how to improve solid-phase synthesis in order to decrease costs, increase scalability, and waste less amino acids and solvents. High-volume industrial production uses liquid-phase peptide synthesis, which can produce higher-quality peptides at a cost of more time.

Liquid Phase Peptide Synthesis Market overview
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Liquid Phase Peptide Synthesis Sector: Growth Drivers and Challenges

Growth Drivers

  • Advancement in Technology – Continuous Advancement in Liquid-phase synthesis methods, such as automated peptide synthesizers and novel coupling chemistries, enhance efficiency and scalability, thereby driving the market’s growth.
  • Expanding Applications- Diversification of peptide synthesis  applications beyond pharmaceuticals, including diagnostics, cosmetics, and research purposes, broadens the market scope and drives growth.
  • Rising Research & Development Activities- Expanded research activities in pharmaceuticals and biotechnology, focusing on developing new peptide-based drugs, stimulate the demand for liquid-phase peptide techniques. For instance, it is reported that  one-pot liquid phase peptide synthesis process that involves adding amino acids to a "nanostar" support iteratively and using organic solvent nanofiltration (OSN) to isolate the developing peptide at the end of each synthesis cycle.This made it possible to synthesize peptides more effectively while keeping all of the advantages of liquid phase synthesis. First, enkephalin-like model penta- and decapeptides were synthesized, followed by octreotate amide, and ultimately octreotate, in order to verify PEPSTAR. In comparison to vendor-produced samples from solid phase synthesis, the crude purities compared satisfactorily.
  • Government Initiatives- Supportive regulatory policies and funding initiatives by the government to promote peptide-based drug development encourage market growth by fostering innovation and investment in Liquid-phase peptide synthesis technology.


  • Complexity in sequence design- peptide synthesis can be complex due to the diversity of peptide sequences desired. Designing and optimizing sequences for desired properties can be challenging.
  • Liquid peptide synthesis can be expensive to plot a large-scale plant.
  • Different amino acids have varying reactivity and compatibility, making it challenging to find suitable reaction conditions for diverse sequences without side reactions or impurities.

Liquid Phase Peptide Synthesis Market: Key Insights

Base Year


Forecast Year



~ 10%

Base Year Market Size (2023)

~ USD 5 Billion

Forecast Year Market Size (2036)

~ USD 15 Billion

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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Liquid Phase Peptide Synthesis Segmentation

End-User (Pharmaceutical & Biotechnology Industry, Contract Development & Manufacturing organizations, Academic & Research Institutes)

Pharmaceutical & biotechnology industry segment is anticipated to hold 45% share of the global liquid phase peptide synthesis market during the forecast period. This is owing to the extensive use of peptides in drug development and manufacturing. For instance, since 2000, 33 non-insulin peptide medications have received approvals across the globe. Furthermore, these peptide medications are no longer just natural amino acid compositions or hormone mimics. For example, ziconotide14,15 is a neurotoxic peptide derived from the cone snail Conus magus, which was approved in 2004 and is used to manage severe chronic pain; teduglutide is a glucagon-like peptide 2 (GLP-2) analog used to treat short bowel syndrome; and enfuvirtide is a 36-amino acid biomimetic peptide mimicking human immunodeficiency virus (HIV) proteins used in combination therapy for the treatment of HIV-112,13.

Application (Therapeutics, Diagnostics, Research Purposes, cosmetics, Food)

The therapeutics segment in the liquid phase peptide synthesis market is estimated to hold a major revenue share by 2036. due to the increasing demand for peptide-based drugs in various disease treatments. The pharmaceutical industry’s continual efforts to harness peptides for targeted therapies and the development of biologics further bolster this segment’s dominance in the market. According to Research Nester Analysts' analysis, the proportion of cancer patients in the United States who qualify for and benefit from genome-targeted therapy has grown over time, rising from an estimated 2.7 in 2006 to 7% in 2020.

Our in-depth analysis of the global market includes the following segments:


  • Pharmaceutical& Biotechnology Industry
  • Contract Development & Manufacturing organizations
  • Academic & Research Institutes


  • Therapeutics
  • Diagnostics
  • Research Purposes
  • Cosmetics
  • Food

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Liquid Phase Peptide Synthesis Industry - Regional Synopsis

North American Market Forecast

North America liquid phase peptide synthesis market is estimated to account for 42% of the revenue share by 2036. The North American market stands as a prominent hub in the global landscape due to several key factors. Fueled by robust research and development activities, the region witnesses extensive utilization of peptides in drug discovery and development by pharmaceutical giants and biotechnology firms. In 2021, research and development expenditure in the United States pharmaceuticals industry amounted to around USD 102 billion. With a strong presence of cutting-edge technology and state-of-the-art infrastructure, North America showcases a significant market share in Liquid Phase Peptide Synthesis.

APAC Market Statistics

Asia Pacific region is also poised to garner significant revenue share, the Asia Pacific liquid phase peptide synthesis market is experiencing substantial growth attributed to several key factors. Rapid economic development, coupled with increasing healthcare expenditure across countries like China, India, Japan, South Korea, and others, is driving the market’s expansion. The region’s pharmaceutical industry is witnessing remarkable advancements, fostering a conducive environment for peptide synthesis technologies. Additionally, the escalating prevalence of chronic diseases and the growing demand for innovative therapeutic solutions fuel the adoption of liquid-phase peptide synthesis in drug discovery and development within the Asia Pacific.

Research Nester
Liquid Phase Peptide Synthesis Market size
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Companies Dominating the Liquid Phase Peptide Synthesis Landscape

    • ©AAPPTec.
    • Company Overview
    • Business Strategy
    • Key Product Offerings
    • Financial Performance
    • Key Performance Indicators
    • Risk Analysis
    • Recent Development
    • Regional Presence
    • SWOT Analysis
    • CEM Corporation
    • Bachem AG
    • CSBio
    • Biotage
    • AnaSpec 
    • ZenBio, Inc
    • Thermo Fisher Scientific Inc. 
    • GenScript
    • PolyPeptide Group


In The News

  • April 2022- The next generation of automated microwave peptide synthesizers, the Liberty 2.0 instrumentation line, has been released by CEM Corporation, with pride. The Liberty 2.0 series is a further advancement of CEM's highly acclaimed SPPS technology, yielding notable improvements in peptide purity, synthesis efficiency, and automation dependability.
  • August 2022- Peptides are well-liked active ingredients in cosmeceuticals, which are cosmetic products. Much research on the topic of dermatology has shown that peptides contribute to the maintenance of a youthful and healthy appearance. Because they can boost the formation of dermal extracellular matrix proteins like collagen, they are especially interesting for anti-aging applications. Additionally, studies have demonstrated that several peptides can encourage angiogenesis, cell migration, and wound healing.

Author Credits:  Radhika Gupta, Shivam Bhutani

  • Report ID: 3221
  • Published Date: Jan 05, 2024
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

Growing demand for peptide-based therapeutics, expanding applications, research and development, and supportive government policies are some of the major growth factors for the market’s growth.

The market size of liquid phase peptide synthesis is anticipated to attain a CAGR of 10 % over the forecast period, i.e., 2024-2036.

The major players in the market are CEM Corporation, Bachem AG, CSBio, Biotage, AnaSpec, ZenBio, Inc., Thermo Fisher Scientific Inc., GenScript, PolyPeptide Group, Sosei Group Corporation, Tokyo Mirai Style Co., Ltd., and others.

The Therapeutics segment is anticipated to garner the largest market size by the end of 2036 and display significant growth opportunities.

The market in the North American region is projected to hold the largest market share by the end of 2036 and provide more business opportunities in the future.
Liquid Phase Peptide Synthesis Market Report Scope

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