Hydrophobic Interaction Chromatography Market Segmentation:
Product Segment Analysis
The resins segment is poised to hold the largest product share of 48.5% in the hydrophobic interaction chromatography market by the end of 2035. This dominance is attributable to their status as recurring, consumable revenue generators that are essential for every purification cycle, which is further fueled by the ongoing development of novel ligands offering higher binding capacity and stability. Exemplifying the same, in January 2025, Bio-Rad Laboratories introduced a scalable weak anion exchange and hydrophobic interaction (AEX-HIC) mixed-mode chromatography resin, Nuvia wPrime 2A Media, which can support both pilot and manufacturing-scale downstream purification processes.
Application Segment Analysis
The protein & antibody purification is predicted to dominate the field of application in the hydrophobic interaction chromatography market with a 65.4% share over the discussed period. The explosive growth in this segment is primarily fueled by the continuous expansion in biologics pipelines, particularly monoclonal antibodies (mAbs). Evidencing the same, a report from the American Chemical Society unveiled that sales of biologics are expected to outperform innovative small molecules by USD 120 billion from 2021 to 2027, while accounting for 55% of all innovative drug sales. Thus, HIC being a critical polishing step in mAb production to remove aggregates and fragments, revenue generation from this application is higher than in other categories in the sector.
End user Segment Analysis
Pharmaceutical & biotechnology companies are poised to represent the dominant end-user segment in the hydrophobic interaction chromatography market throughout the assessed timeframe, with a 55.7% of overall share. This leadership is pledged to the growing need for high-purity biologics, such as mAbs, therapeutic proteins, and vaccines. Besides, the increasing R&D activities in the biopharmaceutical industry are also creating a strong emphasis for HIC on product quality and safety. Thus, the cash inflow in advanced chromatography technologies from pharma and biotech firms continues to rise evidently, solidifying their leading role in this sector as the largest investors.
Our in-depth analysis of the hydrophobic interaction chromatography market includes the following segments:
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