Fibrin Sealants Market Size & Share, by Type (Liquid, Patch, Powder); Application (General Surgery, Cardiovascular Surgery, Thoracic Surgery, Orthopedic Surgery, Transplant Surgery, Neurosurgery, Dental Surgery, Wound Management); Technology (Autologous Donation, Viral Inactivation, Recombinant Production); End-user (Hospitals, Ambulatory Surgical Centers) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2023-2033

  • Report ID: 4466
  • Published Date: Feb 24, 2023
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2023-2033

Fibrin Sealants Market size is estimated to reach USD 1780 million by the end of 2033, growing at a CAGR of 6% during the forecast period, i.e., 2023-2033. In the year 2022, the industry size of fibrin sealants was over USD 885 million. The growth of the market is primarily attributed to the growing prevalence of several kinds of surgeries, the growing occurrence of blood disorders, and traumatic injuries across the globe. As per the figures provided by the World Health Organization (WHO), each year, 3.16 million individuals die as a consequence of unintentional injuries, while 1.25 million individuals die as a consequence of violence-related injuries on a worldwide level.

Fibrin sealants (FS) are protein-based medical adhesives that aid in wound closure and healing. Though bovine and porcine sources are also available, fibrin sealants are generally extracted from human blood. The fibrin sealant molecule's adhesive characteristics allow it to quickly form a clot at the site of the incision, preventing bleeding and sealing it. Fibrin sealant has also been proven to speed up epithelial cell migration, which promotes faster rates of tissue regeneration. For instance, in a clinical study, it was observed that the use of fibrin sealant in combination with photo-biomodulation therapy has shown promising outcomes in the repair of peripheral nerve injuries, as well as being efficient in the neurorrhaphy process and providing a higher quality of axonal regeneration to the interior of the distal stump.

Fibrin Sealants Market
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Fibrin Sealants Sector: Growth Drivers and Challenges

Growth Drivers

  • Worldwide Growing Count of Surgical Procedures - A wide range of medical disorders are diagnosed, or treated via surgical procedures. Currently, a number of health disorders require prompt treatment that mostly include a surgical procedure. Thus, the growing number of surgical procedures is fueling up the global fibrin sealants market. According to World Health Organization statistics, millions of people undergo surgical treatment each year, with surgical intrusions accounting for approximately 13% of global total disability-adjusted life years (DALYs).
  • Upsurge in Hemophilia Cases – Hemophilia is a genetic bleeding ailment that causes the blood to clot improperly. This may result in both spontaneous bleeding and bleeding after injury or surgery. Therefore, it is anticipated to boost the market’s growth over the forecast period. As per the Centers for Disease Control and Prevention, the overall number of males living in the United States with hemophilia is approximated to be between 30,000 and 33,000.
  • Spiking Numbers of Orthopedic Surgeries – The main focus of orthopedic surgery, or orthopedics, is to care of the musculoskeletal system, which includes the skin as well as the bones, joints, ligaments, tendons, muscles, and nerves, and it is predicted to drive the growth of the global fibrin sealants market. Therefore, spiking number of orthopedic surgeries, including keyhole orthopedic surgery is anticipated to boost the market’s growth. For instance, in 2021, around 6.5 million orthopedic procedures were conducted in the United States.
  • Worldwide Increase in Geriatric Population - According to the figures released by the World Health Organization (WHO), the global population of people aged 60 and up is expected to increase from 1 billion in 2020 to 1.4 billion by 2030. The world's population of people aged 60 and over is predicted to double to 2.1 billion by 2050.
  • Increase in Global Healthcare Expenditure – Growing expenditure on global health by nations is bound to increase the revenue and size of the healthcare industry. According to World Bank data, worldwide healthcare expenditures increased by 9.83% in 2019.


  • Associated Limitations of Fibrin Sealants in Minimally Invasive Surgeries- The market for fibrin sealants may see some difficulty during the forecast period owing to restrictions on the use of fibrin sealants in laparoscopic and minimally invasive surgeries. Additionally, the high expenses linked to treatment methods and the tight guidelines for product approvals may hinder sales development.
  • Disruption and Delays Caused by Supply Chains – Logistical issues created by supply chain disruptions can cause imbalances and shortages in the market. This can severely impact the demand for and sales of fibrin sealants.
  • Stringent Government Policies for Approval of Sealants

Fibrin Sealants Market: Key Insights

Base Year


Forecast Year




Base Year Market Size (2022)

~ USD 885 Million

Forecast Year Market Size (2033)

~ USD 1780 Million

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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Fibrin Sealants Segmentation

Application (General Surgery, Cardiovascular Surgery, Thoracic Surgery, Orthopedic Surgery, Transplant Surgery, Neurosurgery, Dental Surgery, Wound Management)

The global fibrin sealants market can be further divided based on application into cardiovascular surgery, thoracic surgery, orthopedic surgery, neurosurgery, dental surgery, wound management, transplant surgery, and others. Cardiovascular Surgery had a sizable market share in 2021 and is anticipated to increase at the quickest rate over the forecast period. Cardiovascular surgery, also referred to as heart surgery, is a type of surgery that involves operating on the heart to treat serious health issues. According to the World Health Organization (WHO), cardiovascular diseases (CVDs) account for 17.9 million deaths per year, or 32% of all fatalities worldwide, making them the leading cause of death globally. Fibrin sealants are used in cardiovascular surgery to reduce the need for blood and blood product transfusions, improve hemostasis in heparin-treated patients, and control problematic bleeding on vascular anastomoses through tissue sealing. According to estimates, the market for cardiovascular procedures will grow as the number of cardiovascular illnesses rises. One in four fatalities in the United States occurs as a result of heart disease, according to the Centers for Disease Control and Prevention (CDC), which is what is causing the segment to rise.

Type (Liquid, Patch, Powder)

The global fibrin sealant market is segmented and analyzed by type into liquid, patch, and power. Out of the three types, the liquid segment is estimated to gain the largest market share over the projected time frame. This can be attributed to the better procedural results than the patch, and powder type. Furthermore, the quick action and higher rational stability of liquid solutions are expected to propel this market even further. Moreover, the fact that the fibrin sealant patch can achieve hemostasis 3–4 minutes after the application is one of its key benefits. Therefore, it is anticipated to boost the segment’s growth in the region.

Our in-depth analysis of the global market includes the following segments:

                  By Type

  • Liquid
  • Patch
  • Powder

                  By Application

  • General Surgery
  • Cardiovascular Surgery
  • Thoracic Surgery
  • Orthopedic Surgery
  • Transplant Surgery
  • Neurosurgery
  • Dental Surgery
  • Wound Management
  • Others

                  By Technology

  • Autologous Donation
  • Viral Inactivation
  • Recombinant Production
  • Others

                  By End-User

  • Hospitals
  • Ambulatory Surgical Centers
  • Others

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Fibrin Sealants Industry - Regional Synopsis

North American Market Forecast

The North America fibrin sealants market, amongst the market in all the other regions, is projected to hold the largest market share by the end of 2033, backed by the significantly increasing healthcare expenditure, growing occurrence of cardiovascular diseases, and growing count of surgical procedures in the region. According to the surveys, cardiovascular disease is the leading cause of death in the United States, taking one life every 36 seconds and fostering the growth of the fibrin sealant industry.

Due to its sophisticated healthcare system, extensive use of cutting-edge automated analyzers, and sizable target patient population, the US now has a prominent position in the North American fibrin sealant industry. For instance, Sysmex Corporation unveiled the blood coagulation analyzers CN-6000 and CN-3000 in 2018, which are next-generation analyzers in the hemostasis area.

APAC Market Statistics

Additionally, a large concentration of pharmaceutical and biotechnology firms, as well as developing health infrastructure, are fueling the market’s growth for fibrin sealants in the Asia Pacific region. Furthermore, owing to their technologically advanced healthcare systems, novel treatment procedures, and sizable patient populations, China, Japan, and South Korea are considered to be the most lucrative markets in the Asia Pacific region. These countries are predicted to dominate the market in the region in terms of revenue share and expand at a much faster rate than other countries.

Europe Market Forecast

Moreover, market in the Europe region is also expected to have a significant growth over the forecast period, backed by the increasing fibrin sealant sales followed by an increase in cases of various dental problems. Europe's market is currently controlled by countries such as the UK, Germany, Italy, and France. Most people with dentures suffer with confidence, according to a UK survey, as they find it uncomfortable to put loose-fitting dentures in their mouths. In the UK, the market for dental sealants is anticipated to increase significantly throughout the anticipated period owing to the rapidly rising prevalence of dental and oral problems such as tooth decay and periodontal flap closure as well as the rising need for cosmetics. This is majorly owing to the adoption of more advanced and cutting-edge sealant products.

Research Nester
Fibrin Sealants Market Size
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Companies Dominating the Fibrin Sealants Landscape

    • CSL Limited
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Baxter International, Inc.
    • Pfizer Inc.
    • Asahi Kasei Corporation
    • Vivostat A/S
    • Octapharma AG


In The News

  • Asahi Kasei Corporation has acquired Bionova Scientific, LLC, a provider of contract process development and GMP-compliant contract manufacturing services to the biopharmaceutical industry.

  • Grifols S.A. launched VISTASEAL plasma-protein-based bleeding-control solutions. Using Ethicon's airless spray device technology, this medication combines fibrinogen and thrombin, two plasma proteins.

Author Credits:  Radhika Gupta, Shivam Bhutani

  • Report ID: 4466
  • Published Date: Feb 24, 2023
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

Worldwide growing count of surgical procedures, upsurge in hemophilia cases, spiking numbers of orthopedic surgeries, and worldwide increase in geriatric population are some major factors driving the growth of the market.

The market is anticipated to attain a CAGR of 6% over the forecast period, i.e., 2023-2033.

Associated limitations of fibrin sealants in minimally invasive surgeries, delay of surgeries as of COVID-19 restrictions, and stringent government policies for approval of sealants are estimated to hamper the market growth.

The market in North America is projected to hold the largest market share by the end of 2033 and provide more business opportunities in the future.

The major players in the market are CSL Limited, Baxter International, Inc., Pfizer Inc., Asahi Kasei Corporation, Vivostat A/S, Octapharma AG, and others.

The company profiles are selected based on the revenues generated from the product segment, geographical presence of the company which determine the revenue generating capacity as well as the new products being launched into the market by the company.

The market is segmented by type, application, technology, end-user, and by region.

The cardiovascular surgery segment is anticipated to garner the largest market size by the end of 2033 and display significant growth opportunities.
Fibrin Sealants Market Report Scope

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