Global Fibrin Sealants Market Definition
The evolution of contemporary surgical procedures has been significantly influenced by the necessity to efficiently manage hemostasis and tissue sealing during operation. To aid in the promotion of hemostasis and tissue sealing during surgery, a class of substances known as surgical tissue adhesives has been developed. The strongest tissue adhesives now on the market are fibrin sealants, which are also biocompatible and biodegradable.
Moreover, human thrombin, purified, virus-inactivated human fibrinogen, and occasionally other ingredients such as bovine aprotinin and virus-inactivated human factor XIII make up the fibrin sealants. When creating a fibrin clot, these substances imitate the last stages of the body's natural coagulation cascade. In addition, any plasma-derived product used in a surgical environment has a chance of spreading a virus. In reality, the possibility of viral transmission from thrombin and fibrinogen was what put an end to American efforts to produce fibrin sealants. Since then, fresh methods for concentrating and isolating plasma fractions have been created, and national and international standards have been set up to guarantee the security of all plasma-based goods. Before processing, all plasma donors undergo meticulous selection, and their plasma units are tested for virus contamination. In order to create commercial fibrin sealants, all donated plasma and bovine tissue must pass stringent virus reduction/elimination procedures. There haven't been any confirmed instances of viral transmission linked to the use of commercial fibrin sealant owing to this meticulously managed and supervised technique.
Currently, fibrin sealants are employed in a variety of surgical specialties, including dental surgery, plastic, and reconstructive surgery, thoracic surgery, and cardiovascular surgery. The use of fibrin sealants improves the time to hemostasis, lowers blood loss, and reduces complications, all of which have a positive impact on surgical results.
Global Fibrin Sealants Market: Key Insights
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Base Year |
2022 |
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Forecast Year |
2023-2033 |
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CAGR |
~6% |
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Base Year Market Size (2022) |
~ USD 885 Million |
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Forecast Year Market Size (2033) |
~ USD 1780 Million |
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Regional Scope |
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Global Fibrin Sealants Market Size, Forecast, and Trend Highlights Over 2023 - 2033
The global fibrin sealants market is estimated to garner a revenue of ~USD 1780 million by the end of 2033 by growing at a CAGR of ~6% over the forecast period, i.e., 2023 – 2033. Further, the market is expected to generate a revenue of ~USD 885 million in the year 2022. The growth of the market is primarily attributed to the growing prevalence of several kinds of surgeries, the growing occurrence of blood disorders, and traumatic injuries across the globe. As per the figures provided by the World Health Organization (WHO), each year, 3.16 million individuals die as a consequence of unintentional injuries, while 1.25 million individuals die as a consequence of violence-related injuries on a worldwide level.
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Fibrin sealants (FS) are protein-based medical adhesives that aid in wound closure and healing. Though bovine and porcine sources are also available, fibrin sealants are generally extracted from human blood. The fibrin sealant molecule's adhesive characteristics allow it to quickly form a clot at the site of the incision, preventing bleeding and sealing it. Fibrin sealant has also been proven to speed up epithelial cell migration, which promotes faster rates of tissue regeneration. For instance, in a clinical study, it was observed that the use of fibrin sealant in combination with photo-biomodulation therapy has shown promising outcomes in the repair of peripheral nerve injuries, as well as being efficient in the neurorrhaphy process and providing a higher quality of axonal regeneration to the interior of the distal stump.
Global Fibrin Sealants Market: Growth Drivers and Challenges
Growth Drivers
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Worldwide Growing Count of Surgical Procedures - A wide range of medical disorders are diagnosed, or treated via surgical procedures. Currently, a number of health disorders require prompt treatment that mostly include a surgical procedure. Thus, the growing number of surgical procedures is fueling up the global fibrin sealants market. According to World Health Organization statistics, millions of people undergo surgical treatment each year, with surgical intrusions accounting for approximately 13% of global total disability-adjusted life years (DALYs).
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Upsurge in Hemophilia Cases – Hemophilia is a genetic bleeding ailment that causes the blood to clot improperly. This may result in both spontaneous bleeding and bleeding after injury or surgery. Therefore, it is anticipated to boost the market’s growth over the forecast period. As per the Centers for Disease Control and Prevention, the overall number of males living in the United States with hemophilia is approximated to be between 30,000 and 33,000.
- Spiking Numbers of Orthopedic Surgeries – The main focus of orthopedic surgery, or orthopedics, is to care of the musculoskeletal system, which includes the skin as well as the bones, joints, ligaments, tendons, muscles, and nerves, and it is predicted to drive the growth of the global fibrin sealants market. Therefore, spiking number of orthopedic surgeries, including keyhole orthopedic surgery is anticipated to boost the market’s growth. For instance, in 2021, around 6.5 million orthopedic procedures were conducted in the United States.
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Worldwide Increase in Geriatric Population - According to the figures released by the World Health Organization (WHO), the global population of people aged 60 and up is expected to increase from 1 billion in 2020 to 1.4 billion by 2030. The world's population of people aged 60 and over is predicted to double to 2.1 billion by 2050.
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Increase in Global Healthcare Expenditure – Growing expenditure on global health by nations is bound to increase the revenue and size of the healthcare industry. According to World Bank data, worldwide healthcare expenditures increased by 9.83% in 2019.
Challenges
- Associated Limitations of Fibrin Sealants in Minimally Invasive Surgeries- The market for fibrin sealants may see some difficulty during the forecast period owing to restrictions on the use of fibrin sealants in laparoscopic and minimally invasive surgeries. Additionally, the high expenses linked to treatment methods and the tight guidelines for product approvals may hinder sales development.
- Disruption and Delays Caused by Supply Chains – Logistical issues created by supply chain disruptions can cause imbalances and shortages in the market. This can severely impact the demand for and sales of fibrin sealants.
- Stringent Government Policies for Approval of Sealants
Global Fibrin Sealants Market Segmentation
The global fibrin sealants market can be further divided based on application into cardiovascular surgery, thoracic surgery, orthopedic surgery, neurosurgery, dental surgery, wound management, transplant surgery, and others. Cardiovascular Surgery had a sizable market share in 2021 and is anticipated to increase at the quickest rate over the forecast period. Cardiovascular surgery, also referred to as heart surgery, is a type of surgery that involves operating on the heart to treat serious health issues. According to the World Health Organization (WHO), cardiovascular diseases (CVDs) account for 17.9 million deaths per year, or 32% of all fatalities worldwide, making them the leading cause of death globally. Fibrin sealants are used in cardiovascular surgery to reduce the need for blood and blood product transfusions, improve hemostasis in heparin-treated patients, and control problematic bleeding on vascular anastomoses through tissue sealing. According to estimates, the market for cardiovascular procedures will grow as the number of cardiovascular illnesses rises. One in four fatalities in the United States occurs as a result of heart disease, according to the Centers for Disease Control and Prevention (CDC), which is what is causing the segment to rise.
The global fibrin sealant market is segmented and analyzed by type into liquid, patch, and power. Out of the three types, the liquid segment is estimated to gain the largest market share over the projected time frame. This can be attributed to the better procedural results than the patch, and powder type. Furthermore, the quick action and higher rational stability of liquid solutions are expected to propel this market even further. Moreover, the fact that the fibrin sealant patch can achieve hemostasis 3–4 minutes after the application is one of its key benefits. Therefore, it is anticipated to boost the segment’s growth in the region.
Our in-depth analysis of the global fibrin sealants market includes the following segments:
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By Type |
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By Application |
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By Technology |
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By End-User |
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Global Fibrin Sealants Market Regional Synopsis
The North America fibrin sealants market, amongst the market in all the other regions, is projected to hold the largest market share by the end of 2033, backed by the significantly increasing healthcare expenditure, growing occurrence of cardiovascular diseases, and growing count of surgical procedures in the region. According to the surveys, cardiovascular disease is the leading cause of death in the United States, taking one life every 36 seconds and fostering the growth of the fibrin sealant industry.
Due to its sophisticated healthcare system, extensive use of cutting-edge automated analyzers, and sizable target patient population, the US now has a prominent position in the North American fibrin sealant industry. For instance, Sysmex Corporation unveiled the blood coagulation analyzers CN-6000 and CN-3000 in 2018, which are next-generation analyzers in the hemostasis area.
Additionally, a large concentration of pharmaceutical and biotechnology firms, as well as developing health infrastructure, are fueling the market’s growth for fibrin sealants in the Asia Pacific region. Furthermore, owing to their technologically advanced healthcare systems, novel treatment procedures, and sizable patient populations, China, Japan, and South Korea are considered to be the most lucrative markets in the Asia Pacific region. These countries are predicted to dominate the market in the region in terms of revenue share and expand at a much faster rate than other countries.
Moreover, market in the Europe region is also expected to have a significant growth over the forecast period, backed by the increasing fibrin sealant sales followed by an increase in cases of various dental problems. Europe's market is currently controlled by countries such as the UK, Germany, Italy, and France. Most people with dentures suffer with confidence, according to a UK survey, as they find it uncomfortable to put loose-fitting dentures in their mouths. In the UK, the market for dental sealants is anticipated to increase significantly throughout the anticipated period owing to the rapidly rising prevalence of dental and oral problems such as tooth decay and periodontal flap closure as well as the rising need for cosmetics. This is majorly owing to the adoption of more advanced and cutting-edge sealant products.
Top Featured Companies Dominating the Global Fibrin Sealants Market
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CSL Limited
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