Esketamine Nasal Spray Market Outlook:
Esketamine Nasal Spray Market size was valued at USD 27.11 billion in 2025 and is set to exceed USD 52.34 billion by 2035, registering over 6.8% CAGR during the forecast period i.e., between 2026-2035. In the year 2026, the industry size of esketamine nasal spray is estimated at USD 28.77 billion.
The primary factor that is set to drive the market for esketamine nasal spray and take it to the expected growth is the rise in the number of patients who require esketamine nasal spray. To illustrate a study made in 2023 almost 27.1% of patients on esketamine NS received remission and require this to cure their problem of depression. As Esketamine are utilized for treatment-resistant depression, and it is the patients’ first choice to have esketamine NS.
Additionally, another factor that will cast the esketamine nasal spray market to its expected growth is the several initiatives that were continuously taken by the world powers to combat the condition of depression. In 2019, WHO created the WHO Special Initiative for Mental Health (2019-2023): Universal Health Coverage for Mental Health to ensure the availability of quality and affordable care for mental health conditions in 12 priority countries to 100 million more people. Depression and self-harm/suicide are among the most important situations covered by WHO’s Mental Health Gap Action Programme (mhGAP) in 2023. The program focuses on assisting countries to prevalent services for people with mental, neurological, and material implementation disorders through attention given by health workers who are not experts in mental health. WHO has formulated concise psychological intervention manuals for depression that may be submitted by lay therapists to singles and groupsFurthermore, the Group Interpersonal Treatment for depression manual explains group treatment of depression. Lastly, the Thinking Healthy manual encircles the utilization of cognitive-behavioral treatment for ante-natal depression.
