Rheumatoid Arthritis Treatment Market Size & Share, by Type (Biologics, Non-Biologics); Molecule; Drug Category; Distribution Channel; Route of Administration - SWOT Analysis, Competitive Strategic Insights, Regional Trends 2025-2037

  • Report ID: 3311
  • Published Date: Jul 18, 2025
  • Report Format: PDF, PPT

Rheumatoid Arthritis Treatment Market Outlook:

Rheumatoid Arthritis Treatment Market size was over USD 36 billion in 2024 and is estimated to reach USD 78 billion by the end of 2037, expanding at a CAGR of 6.9% during the forecast timeline, i.e., 2025-2037. In 2025, the industry size of rheumatoid arthritis treatment is estimated at USD 38 billion.  

In 2024, the global RA patient population was over 16 million. The supply chain of RA therapies is extremely internationalized. Manufacturers tend to hold approximately 17-25 months of safety stock for APIs. In 2023, the Producer Price Index (PPI) for pharmaceutical preparations, which include RA drugs, was 2% higher. During this time, the Consumer Price Index (CPI) for prescription medicines was 3.2% higher. Product price levels were maintained, and government auditors reported drug class price inflation was 1.3% higher than overall medicine price inflation.

R&D expenditure for RA treatments currently exceeds USD 1 billion per year globally. The FDA further reports over 1,100 Drug Master Files (DMFs) for RA APIs submitted in the last 24 months. This reflects a diverse range of regulatory variety and activity. Trade in APIs (Raw Medicines) for RA drugs provides us with significant import-export volumes. Finished dosage forms were mostly exported from the EU. In the U.S. to the developing markets, raw materials generally make their way through multi-modal supply chains.

Rheumatoid Arthritis Treatment Market Size
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Growth Drivers  

  • Healthcare quality improvement via EHR & PRO integration: AHRQ-supported projects like UCSF's use of NLP technology to extract patient-reported outcomes (PROs) from clinical notes. This has improved the quality of RA care, particularly for underserved populations. Thus, investing in digital approaches to capturing and acting on PRO data will support payers and providers trying to provide value-based reimbursement. AHRQ projects demonstrate how PRO dashboards promote shared decision-making and self-efficacy in RA care. Biopharma companies can establish performance-based pricing that links to real-world adherence and outcomes using EHR-integrated PRO systems.
  • Patient pool trends & care disparities: RA impacts around 1.1 million Americans. This highlights the underserved demand. Targeted outreach and funding for community health programs can meet unmet demand and help to improve equity in the delivery of care. According to the Digital Healthcare Research Program at AHRQ, RISE registry data indicate that several quality improvement interventions positively improved adherence to RA activity measures. Manufacturers and technology partners provide support to healthcare systems through analytical support and training to improve performance metrics.

Historical Patient Growth for RA Treatment Users (2010–2020)

Country

2010 Patient Population (millions)

2020 Patient Population (millions)

Growth (%)

USA

1.48

1.80

25%

Germany

0.62

0.80

21.4%

France

0.48

0.60

23.3%

Spain

0.35

0.47

28.2%

Australia

0.20

0.30

26.1%

Japan

0.72

0.89

13.5%

India

2

3.10

48.4%

China

4.75

6.80

42.3%

Synopsis: Feasible Expansion Models Reshaping the RA Treatment Market

New expansion models developing in the rheumatoid arthritis (RA) therapy space increasingly emphasize partnerships. These models suggest a future of growth based on scalable cost savings and expanded access. With governmental involvement increasing, the RA market is in a position that more inclusively facilitates sustainable growth that is driven by volume.

Statistical Revenue Feasibility Models

Country

Model

Timeframe

Revenue/Access Impact

India

Biosimilar licence with local distributor

2014–2024

>11% ↑ revenue

USA

Biosimilar uptake modeling

2021–2025

USD 38 billion savings

Brazil

Public health inclusion of tsDMARDs

2019–2023

+34% patient treatment

Greece

Biologics vs total RA spend

2014–2015

Biologics = 64%

Challenges

  • Prohibitively high treatment cost: Biologics can cost over USD 25700 per annum per patient in the US. The World Health Organization (WHO) cites that biosimilars are 59% lower. However, the high price of originators inhibits use. According to the WHO, out-of-pocket expenses are the largest financial barrier. Moreover, tender systems based on the lowest cost often led to supply shortages or discourage new entrants.
  • Regulatory delays and price negotiations: Regulatory delays add time to the timeline for new RA treatments to reach the market. This ultimately slows the ability of the market to incorporate innovation. Longer timelines mean higher R&D costs for drug developers. This can deter investment in new RA therapeutics.

Rheumatoid Arthritis Treatment Market Size and Forecast:

Report Attribute Details

Base Year

2024

Forecast Year

2025-2037

CAGR

6.9%

Base Year Market Size (2024)

USD 36 billion

Forecast Year Market Size (2037)

USD 78 billion

Regional Scope

  • North America (U.S., and Canada)
  • Asia Pacific (Japan, China, India, Indonesia, Malaysia, Australia, South Korea, Rest of Asia Pacific)
  • Europe (UK, Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Latin America (Mexico, Argentina, Brazil, Rest of Latin America)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)

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Rheumatoid Arthritis Treatment Market Segmentation:

Product Type Segment Analysis 

Based on the product type, the biologics segment is predicted to capture the largest share at 63% in the rheumatoid arthritis treatment market over the assessed period. Biologics, including both the originators and the biosimilars, will continue to dominate because they continue to show a great deal of efficacy, especially in cases of severe RA. The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) standards highlight the rationale for using biosimilars that have an approximate 58% cost savings each time a biosimilar is used. Biologics gain more covered decisions in the clinical guidelines, and will retain the highest market share.

Drug Category Segment Analysis  

In terms of drug category, the biosimilars segment is anticipated to hold the highest revenue proportion of 36% in the rheumatoid arthritis treatment market throughout the discussion. Globally, payer cost containment strategies drive biosimilar uptake. CDC states biosimilars substantially reduce immunogenicity risks and cost burdens. The biosimilar introductions into the EU and US markets enabled innovative payers to begin shifting biosimilars into their reimbursement formularies. This made biosimilars one of the hick rapid growing sub segments of pharmaceuticals.

Our in-depth analysis of the global market includes the following segments: 

Segment

Subsegments

Type

  • Biologics
  • Non-Biologics

Molecule

  • TNF α inhibitors
  • JAK inhibitors
  • IL 6 inhibitors
  • Others

Drug Category

  • Originator biologics
  • Biosimilars

Distribution Channel

  • Hospital pharmacy
  • Retail pharmacy
  • Online pharmacy

Route of Administration

  • Subcutaneous injections
  • Intravenous infusions
  • Oral therapies
Vishnu Nair
Vishnu Nair
Head - Global Business Development

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Rheumatoid Arthritis Treatment Market - Regional Analysis

North America Market Insights 

North America is expected to dominate the global rheumatoid arthritis treatment market with a share of 31% by the end of 2037. The main drivers of this trend are the large number of people with rheumatoid arthritis (RA) in the population, a good payer system, and the rapid adoption of biologics and biosimilars more widely. In the United States, the existence of an integrated network of healthcare systems along with the expansion of Medicaid and Medicare coverage increased the demand. Also, new lanes that regulators have established and the use of real-world evidence have allowed biosimilars to gain traction at a faster rate. In Canada, the one-payer system and comprehensive provincial drug plan allow for equitable access. Overall, evidence suggests that biosimilars are experiencing a lot of uptake, and access trends in North America are also showing a significant uptake of biosimilars. Investments in implementation science in the areas of tele-rheumatology and digital monitoring or assessment tools are also enhancing adherence as well as outcomes.

The rheumatoid arthritis (RA) market in the U.S. is flourishing thanks to bipartisan support from federal and state agencies and payers. In fiscal year 2023, the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS Também) budget reached an astounding USD 675 million. Medicaid earmarked around USD Rates of on How-to Data for RA biologics and disease-modifying antirheumatic drugs for 2024. Other aspects of the U.S. RA market include 1) the rapid uptake of biosimilars once approved by the FDA, and the scope of telehealth enabled by improving CMS policy surrounding telehealth coverage, so that access has expanded for populations in rural areas. Finally, the investment in research for rheumatic diseases, through NIH grant programs and other investments, is steady and strong. Overall incorporation, the aligning of government funding, payer reimbursement, policies that advance the pace of change, and research investment are all contributing to growth in the U.S.

Canada's RA market benefits from single-payer provincial systems that foster considerable access to both biologics and the biosimilar products that are available. Ontario increased RA spending by 16% from 2021-2024. Public funding of RA Research from PHAC and the Canadian Institutes for Health Research is promoting home-grown innovation. Tele-rheumatology programs are extending care into rural communities. Innovative Medicines Canada is aligning with provincial payers to create opportunities for outcome-based drug reimbursement.

APAC Market Insights 

Asia Pacific is poised to register the highest pace of growth in the global rheumatoid arthritis treatment market by the end of 2037. Factors supporting growth include broadening the pathways for approving biosimilars, increasing and long-term burden of the disease, and increasing government funding. Overall, the region is entering a phase of growth that corresponds with increased access to biosimilars, effects from changes in reimbursement, changing demographics, and increasingly fluxing policy frameworks. According to the National Medical Products Administration (NMPA), in China, there were over 1 million identified RA patients in 2023. This resulted in a 14% increase in RA drug approvals. In India, ICMR acknowledges RA as a priority. The increased demand for services related to RA has been compounded by the growth of the senior population. For example, government spending on RA had reached USD 1 billion annually in 2023.

APAC Countries Spending and Developments

Country

RA Patients (2023)

2023 Spending (USD)

Biologic/Biosimilar Access Notes

Japan

430,100

$9.5 billion

Strong JAK inhibitor and biosimilar adoption

Australia

210,020

$2.2 billion

Funded under PBS; rise in biologic use post-2021

Malaysia

115,100

$241 million

Formulary expansion since 2021, increased access

South Korea

650,100

$872 million

High DMARD adoption, active biosimilar production

Europe Market Insights 

The Europe rheumatoid arthritis treatment market is estimated to garner a notable industry value from 2025 to 2037. The growth is driven by the global uptake of biosimilars, the availability of strong public reimbursement policies, and unique digitized patient registries across Europe. The developing Rx Guidance for biosimilars provided by the EMA and the EU pharmaceutical strategy that are promoting generic medicines will make a huge impact in Europe. Investments in primary care and access points have contributed to long-term cost reductions.  The reimbursement practices in Italy and Spain have taken payment from cure to a sustainable implementation. The entire RA market is moving forward in Europe with better uptake of biosimilars, improved regulatory harmonization, and value-driven procurement.

Germany's forecast for RA continues to be the largest prop of the European RA market. The health system's high market share is propelled by its statutory health coverage. Germany is especially keen on RWE-based registries that help support value-based contracts. Increasing exposure to JAK inhibitors also bolsters the overall growth of the RA segment in Germany. The United Kingdom is well-positioned in the market owing to NHS-led biosimilar substitution. NICE health technology assessments help identify pricing models to increase cost-effective uptake rapidly. National registries such as the BSRBR-RA registries provide rapidly available safety/off-label use data. Notably, the United Kingdom is developing new value-based NHS commissioning for specific RA therapies. This will quantifiably tie reimbursement first to patient outcomes.

Rheumatoid Arthritis Treatment Market Share
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Key Rheumatoid Arthritis Treatment Market Players:

    The RA treatment market in 2024 is still quite consolidated. Pfizer and Amgen are at the forefront of biosimilar development, with quick approvals making treatments more affordable. Asian companies are making a name for themselves globally by offering cost-effective, high-quality biosimilars. Strategic partnerships are helping these companies expand their global reach.

    Company Name

    Country

    2024 Market Share (%)

    AbbVie Inc.

    USA

    27.2%

    Pfizer Inc.

    USA

    11.7%

    Amgen Inc.

    USA

    9.9%

    Johnson & Johnson

    USA

    5.5%

    Roche Holding AG

    Switzerland

    5.1%

    Novartis AG

    Switzerland

    xx%

    Eli Lilly & Co.

    USA

    xx%

    Sanofi

    France

    xx%

    UCB S.A.

    Belgium

    xx%

    Biogen Inc.

    USA

    xx%

    Bristol Myers Squibb

    USA

    xx%

    Sandoz (Novartis Division)

    Switzerland

    xx%

    Celltrion Inc.

    South Korea

    xx%

    Biocon Biologics Ltd.

    India

    xx%

    Samsung Bioepis

    South Korea

    xx%

    Astellas Pharma Inc.

    Japan

    xx%

    Daiichi Sankyo

    Japan

    xx%

    CSL Limited

    Australia

    xx%

    Pharmaniaga Berhad

    Malaysia

    xx%

    Lupin Pharmaceuticals

    India

    xx%

    Below are the areas covered for each company in the market: 

    • Company Overview 
    • Business Strategy 
    • Key Product Offerings 
    • Financial Performance 
    • Key Performance Indicators 
    • Risk Analysis 
    • Recent Development 
    • Regional Presence 
    • SWOT Analysis 

Recent Developments

  • In April 2024, Teva Pharmaceuticals and Alvotech rolled out SIMLANDI. This is a game-changer as it’s the first high-concentration, citrate-free version of adalimumab available in the U.S.
  • In April 2025, AbbVie rolled out RINVOQ. This is marking it as the first oral Janus kinase (JAK) inhibitor aimed at treating Giant Cell Arteritis (GCA). This strategic move is anticipated to enhance AbbVie’s market share in the JAK inhibitor category by about 7–9% by 2025.
  • Report ID: 3311
  • Published Date: Jul 18, 2025
  • Report Format: PDF, PPT

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Frequently Asked Questions (FAQ)

In the year 2025, the industry size of rheumatoid arthritis treatment is evaluated at USD 38 billion.

Rheumatoid Arthritis Treatment Market size was valued at USD 36 billion in 2024 and is set to exceed USD 78 billion by 2037, expanding at over 6.9% CAGR during the forecast period i.e., between 2025-2037.

North America is expected to dominate the global rheumatoid arthritis treatment market with a share of 31% by the end of 2037.

The major players in the market are AbbVie Inc., Pfizer Inc., Amgen Inc., Johnson & Johnson, Roche Holding AG, Novartis AG, Eli Lilly & Co., Sanofi, UCB S.A., Biogen Inc., Bristol Myers Squibb, Sandoz (Novartis Division), Celltrion Inc., Biocon Biologics Ltd., Samsung Bioepis , among others.
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