Potassium-Sparing Diuretics Market Analysis by Application (Edema, Hypertension, Heart Failure, Liver Cirrhosis, and Others); and by Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies, and Others – Global Supply & Demand Analysis & Opportunity Outlook 2023-2035

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Global Potassium-Sparing Diuretics Market Size, Forecast, and Trend Highlights Over 2023 – 2035

The global potassium-sparing diuretics market size is estimated to reach ~USD 163 Million by the end of 2035 by growing at a CAGR of ~6% over the forecast period, i.e., 2023 – 2035. In addition to this, in the year 2022, the market size of potassium-sparing diuretics was ~USD 100 Million. The growth of the market can be attributed to the increasing prevalence of hypertension and metabolic disorders. According to WHO statistics, nearly 1.28 billion adults aged 30–79 worldwide suffer from hypertension, the majority (80%) living in low- and middle-income countries. According to the CDC, nearly half of Americans (46 percent, or 116 million) suffer from hypertension, which is defined as a systolic blood pressure over 130 mmHg or a diastolic blood pressure over 80 mmHg or are taking hypertension medications. Potassium-sparing diuretics help to reduce blood pressure by increasing the amount of potassium in the body. This helps to reduce the levels of sodium in the bloodstream, which in turn reduces the amount of fluid in the body and thus the pressure of the blood on the walls of the blood vessels.

In addition to these, factors that are believed to fuel the market growth of potassium-sparing diuretics include the increasing demand for better healthcare and innovations in the drug delivery system. Moreover, the growing number of investments in the healthcare sector and increased awareness of the availability and importance of these medications are also expected to contribute to market growth. The United States spent more than 17 percent of its GDP on healthcare in 2021. Nearly USD 28 billion was invested in the Indian healthcare sector between April 2000 and December 2021. Governments around the world are investing heavily in healthcare infrastructure and services, which is contributing to increased awareness of health and wellness, and in turn, driving the demand for potassium-sparing diuretics for a variety of ailments.

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Global Potassium-Sparing Diuretics Market: Key Insights

Base Year


Forecast Year




Base Year Market Size (2022)

~ USD 100 Million

Forecast Year Market Size (2035)

~ USD 163 Million

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)


Global Potassium-Sparing Diuretics Market: Growth Drivers and Challenges


Growth Drivers

  • Higher Rates of Obesity Among Adults - There are approximately 1 in 11 adults (9.2%) who have severe obesity in the United States. There is a greater proportion of overweight men (34.1%) than overweight women (27.5%). With an increase in obesity, there is an increase in the risk of developing high blood pressure and heart disease which results in an increase in the need for medications like potassium-sparing diuretics. These medications work to lower the levels of sodium and water in the body, which can help reduce the risk of associated health problems.
  • Huge Number of People Suffering from Chronic Diseases - According to estimates, 6 out of 10 Americans have a chronic disease. There are about 40 million Americans who are limited in their normal activities owing to chronic health issues. Potassium-sparing diuretics are medications used to treat high blood pressure, fluid retention, and other conditions caused by water retention. Their use is increasing owing to the rising prevalence of chronic diseases such as diabetes, hypertension, and heart failure, which increase the risk of fluid retention.
  • A Growing Awareness Of Edema And Pulmonary Edema Prevalence - The prevalence of pulmonary edema among patients with heart failure is estimated to be 75000-83,000 cases per 100,000 individuals worldwide. Edema is swelling in the body caused by excess fluid trapped within the tissues. As more people become aware of edema, they are increasingly seeking treatments, such as diuretics, to reduce the excess fluid. Doctors are also becoming more aware of the condition, leading to earlier detection and better treatments.
  • Increasing Incidence of Cirrhosis Among Adults - Cirrhosis is a chronic liver disease which is characterized by fibrosis and the formation of scar tissue. This causes the liver to not be able to function properly and can lead to a buildup of potassium in the body, which can be dangerous. Potassium-sparing diuretics help to flush out the excess potassium and can help to reduce the symptoms of cirrhosis. It is estimated that about one in four hundred adults in the United States have cirrhosis. The prevalence of cirrhosis is higher in adults between the ages of 45 and 54. Cirrhosis affects about one in every 200 Americans aged 45 to 54.
  • A Rise In The Number Of Heart Failure Cases - The Centers for Disease Control and Prevention estimates that approximately 6.2 million Americans have heart failure. According to death certificates, heart failure contributed to 379,800 deaths in 2018 (13.4%). Potassium-sparing diuretics are used to treat congestive heart failure and other cardiac-related conditions as they help the body to eliminate excess fluid and sodium while preserving potassium. This helps to reduce the strain on the heart, which in turn can help to improve symptoms and increase quality of life.


  • Availability of generic alternatives - Generic drugs tend to be significantly cheaper than their brand-name counterparts, and since potassium-sparing diuretics are already relatively inexpensive, the presence of generics reduces the incentive for people to purchase the more expensive brand-name drugs. This results in a decrease in market growth for potassium-sparing diuretics.
  • High cost of potassium-sparing diuretics
  • Stringent regulations imposed by governments to control the usage of these drugs

Global Potassium-Sparing Diuretics Market Segmentation

The global potassium-sparing diuretics market is segmented and analyzed for demand and supply by application in edema, hypertension, heart failure, liver cirrhosis and others. Out of these, the hypertension segment is estimated to gain the largest market share of about ~32% in the year 2035. The growth of the segment can be attributed to the increasing prevalence of hypertension globally owing to rising obesity and unhealthy and sedentary lifestyle habits. Approximately 60% of U.S. adults do not participate in the recommended amount of physical activity. It is estimated that 25 percent of U.S. adults are not physically active at all. Unhealthy lifestyle habits such as lack of physical activity, unhealthy dietary habits, smoking and alcohol consumption have been associated with increasing levels of obesity, which in turn increases the risk of hypertension. Additionally, increasing government initiatives for preventative healthcare and awareness about hypertension and its risk factors are also expected to contribute to the growth of this segment.

The global potassium-sparing diuretics market is segmented and analyzed for demand and supply by distribution channel into hospital pharmacies, retail pharmacies, online pharmacies and others. Out of these, the hospital pharmacies segment is estimated to gain a significant market share of about ~29% in the year 2035. The hospital pharmacies segment is expected to grow at a rapid pace owing to the increasing demand for generic drugs in hospitals, rising number of surgeries, and increasing spending capacity on healthcare in developing countries. Moreover, hospital pharmacies have access to more specialized equipment and a wider range of medications than regular pharmacies, which allows them to provide more tailored medication to their patients, resulting in a growing number of hospitals with specialty pharmacies. It was observed that more than 21% of hospitals have specialty pharmacies in 2018, up from less than 8% in 2016. Furthermore, rising investments in healthcare infrastructure and the presence of a large number of hospitals in urban and rural areas are also expected to drive the growth of the segment.

Our in-depth analysis of the global potassium-sparing diuretics market includes the following segments:


By Application

  • Edema
  • Hypertension
  • Heart Failure
  • Liver Cirrhosis
  • Others

By Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies
  • Others

Global Potassium-Sparing Diuretics Market Regional Synopsis


The market share of potassium-sparing diuretics in North America, amongst the market in all the other regions, is projected to be the largest with a share of about ~39% by the end of 2035. The growth of the market can be attributed primarily to the increasing prevalence of cardiovascular diseases and the increasing demand for safe and effective medicines. The increasing acceptance of new technologies and the growing number of clinical trials for the development of new drugs and treatments as well as the growing investments in research and development activities by pharmaceutical and biotechnological companies, are also expected to aid in the growth of the market. A total of USD 83 billion was spent on R&D by the pharmaceutical industry in 2019 in the United States. Also, from 2010 to 2019, 59 novel drugs were approved for sale, a 60 percent increase over the previous decade. Companies are investing in research and development activities in order to develop newer and more effective potassium-sparing diuretics that can help those suffering from illnesses such as hypertension, congestive heart failure, and edema. Furthermore, the rising number of initiatives taken by governments and private organizations to create awareness about cardiovascular diagnostics and their treatments, are expected to fuel regional market growth.

The Asia Pacific potassium-sparing diuretics market is estimated to be the second largest, registering a share of about ~25% by the end of 2035. The growth of the market can be attributed majorly to the increasing populace of geriatrics suffering from chronic kidney diseases as well as hypertension and other cardiovascular diseases. The study indicated that the overall self-reported prevalence of diagnosed CVDs was 30% for older adults aged 45 and above in India. Also, as per WHO, China's population is ageing at the fastest rate in the world. Chinese citizens over 60 are expected to reach 28% by 2040. As people age, they often develop hypertension and other conditions that require diuretics to manage water retention. Potassium-sparing diuretics are preferred for elderly individuals as they are gentler on the kidneys and help retain potassium levels, which are important for proper functioning of the heart and other organs. In addition, increasing health awareness and initiatives by governments to control the prevalence of diabetes and hypertension, and the growing focus on preventive healthcare are expected to contribute to the growth of the Asia Pacific potassium-sparing diuretics market in the near future.

Further, the potassium-sparing diuretics market in the Europe, amongst the market in all the other regions, is projected to hold a majority of the share by the end of 2035. The growth of this market can be attributed to the rising prevalence of lifestyle diseases such as hypertension and diabetes. A growing awareness of early diagnosis and treatment options among regional populations is expected to boost demand for potassium-sparing diuretics. As people become more aware of the early signs of kidney disease, they are more likely to seek medical attention and treatment. Potassium-sparing diuretics are becoming increasingly popular as they help to reduce the risk of developing kidney disease.

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Top Featured Companies Dominating the Global Potassium-Sparing Diuretics Market

    • Pfizer Inc.
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Merck Sharp & Dohme Corp.
    • Accord Healthcare
    • Amneal Pharmaceuticals LLC
    • Centaur Pharmaceuticals Pvt. Ltd.
    • Validus Pharmaceuticals LLC
    • Teva Pharmaceutical Industries Ltd.
    • CMP Pharma
    • Boehringer Ingelheim GmbH
    • Bayer AG


In The News

  • A new FDA approval for Merck & Co., Inc., VERQUVO® (vericiguat) has been announced. heart failure (HF) hospitalization risk reduction with VERQUVO in adults with symptomatic chronic heart failure and a low ejection fraction (45%) after heart failure hospitalization or need for intravenous (IV) diuretics in adults.

  • In a joint announcement today, Boehringer Ingelheim GmbH and Eli Lilly and Company announced that Jadix® (empagliflozin) 10 mg has been approved by the U.S. Food and Drug Administration for the reduction of cardiovascular death and hospitalization associated with heart failure in adults with heart failure with reduced ejection fractions (HFrEF).


Global Economic Impact

Request Insights
Despite Inflation & Fearing Recession, Businesses Across the Globe Expected to Do Better in 2023:

In 2023, market players might incur losses due to huge gap in currency translation followed by contracting revenues, shrinking profit margins & cost pressure on logistics and supply chain.
Controlling Inflation has become the first priority for global economies from last quarter of 2022 and to be followed in 2023. With skewed economic situations, rise in interest rate by governments to control spending and inflation, spiked oil and gas prices, high inflation, geo-political issues including U.S. & China trade war, Russia-Ukraine conflict to intensify the global economic issues.
The interest rates in the U.S. may be less sensitive in 2023 as compared to 2022; sigh of relief for businesses. Positive business sentiments, healthy business balance sheets, growth in construction spending (private construction value in 2022 stood at $1,429.2 billion, 11.7 percent (±1.0 percent) above the $1,279.5 billion spent in 2021, Residential construction in 2022 was $899.1 billion, up by 13.3 percent (±2.1 percent) from $793.7 billion in 2021, non-residential construction touched $530.1 billion, 9.1 percent (±1.0 percent) above the $485.8 billion in 2021.) showcases minimal impact of recession in the country.
Similarly, spiked spending in the European and major Asia economics including, India, China & Japan to showcase less impact on the global demand.

Author Credits:  Radhika Gupta, Shivam Bhutani

Key Questions Answered in the Report

1) What are the major factors driving the growth of the potassium-sparing diuretics market?

Ans: The growing prevalence of chronic diseases, such as hypertension and kidney diseases, and the increasing demand for better treatments are the major factors driving the market growth.

2) What would be the CAGR of potassium-sparing diuretics market over the forecast period?

Ans: The market size of potassium-sparing diuretics is anticipated to attain a CAGR of ~6% over the forecast period, i.e., 2023 – 2035.

3) What are the challenges affecting the potassium-sparing diuretics market growth?

Ans: High cost of potassium-sparing diuretics, coupled with the availability of generic alternatives are estimated to be the growth hindering factors for the market expansion.

4) Which region will provide more business opportunities for growth of potassium-sparing diuretics market in future?

Ans: The market in the North America region is projected to hold the largest market share by the end of 2035 and provide more business opportunities in the future.

5) Who are the major players dominating the potassium-sparing diuretics market?

Ans: The major players in the market are Pfizer Inc., Merck & Co., Inc., Accord Healthcare, Amneal Pharmaceuticals LLC, Centaur Pharmaceuticals Pvt. Ltd., Validus Pharmaceuticals LLC, Teva Pharmaceutical Industries Ltd., CMP Pharma, Boehringer Ingelheim GmbH, Bayer AG

6) How are the company profiles selected?

Ans: The company profiles are selected on the basis of revenues generated from the product segment, geographical presence of the company which determine the revenue generating capacity as well as the new products being launched into the market by the company.

7) What are the segments in the potassium-sparing diuretics market?

Ans: The market is segmented by application, distribution channel and by region.

8) Which segment captures the largest market size in the application segment in the potassium-sparing diuretics market?

Ans: The hypertension segment is anticipated to garner the largest market size by the end of 2035 and display significant growth opportunities.

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