Orthobiologics Market Size & Share, by Solutions {Bone Graft Substitutes (Demoralized Bone Matrix, Bone Allografts, Bone Autographs, Bone Morphogenic Proteins, Bone Growth Stimulators), Visco-Supplementation (5, 3 Injection Visco-Supplementation, Single Injection Visco-Supplementation)}; Application (Spinal Fusion, Trauma Repair, Reconstructive Surgery); End-user (Clinics, Hospitals) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2023-2033

  • Report ID: 773
  • Published Date: Feb 09, 2023
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2023-2033

Orthobiologics Market size is poised to cross robust revenue by the end of 2033, growing at a CAGR of 6% during the forecast period, i.e., 2023-2033. In the year 2022, the industry size of orthobiologics cross robust revenue. The growth of the market can primarily be accounted to the rising cases of bone diseases across the globe. Based on the report provided by the National Library of Medicine (NLM), it was observed that around 1.5 million people suffer from fractures owing to some sort of bone disease every year.

Global orthobiologics market trends such as, the growing prevalence of low immunity and calcium deficiency owing to changing lifestyles and skyrocketing spending on medical technology are projected to influence the growth of the market positively over the forecast period. As of 2019, the total revenue generated by medical technology was anticipated to be nearly USD 450 billion while the R&D spending on this technology was estimated to be around USD 30 billion in the same year. Orthobiologics is an injectable therapy that utilizes biological substances to heal musculoskeletal injuries rapidly. The substances used in the therapy are made from the materials naturally produced by the body. Therefore, all these factors are anticipated to propel the growth of the market over the forecast period.

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Orthobiologics Sector: Growth Drivers and Challenges

Growth Drivers

  • Growing Number of Bone Fractures to Boost the Market Growth
  • For instance, the estimated number of bone fractures received is approximately 1000 fractures per 100,000 people every year.
  • Increasing Sales of Orthopedic Devices
  • As of 2022, the orthopedic devices segment was valued at around USD 40 billion.
  • A wide array of technologies is included in orthobiologics to improve the functionality of the broken bone. Components such as, scaffolds to reinforce tissue, cell therapies, and bone grafting materials are used in the therapy. Orthobiologics is associated with bone injuries, for instance, osteoporosis, osteonecrosis, bone infection, and density.
  • Higher Prevalence of Orthopedic Injuries
  • The prevalence of orthopedic injuries can be observed by the fact that more than 6 million orthopedic surgeries are performed every year solely in the USA.
  • Rising Cases of Osteoporosis Across the Globe
  • It is observed that 1 in 2 women and 1 in 5 men aged 50 or over suffer from osteoporosis globally. Furthermore, in 2017-18, more than 18% of women were predicted to be living with osteoporosis.
  • Significant growth in the Healthcare Expenditure
  • World Bank published statistics showing that in 2019, the healthcare expenditure reached 1,121.9 U.S. dollars per Capita.


  • Higher Cost Associated with the Treatment
  • Lack of Skilled Medical Professionals and Requisite Technology
  • Presence of the Alternatives in the Market

Orthobiologics Market: Key Insights

Base Year


Forecast Year




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Orthobiologics Segmentation

End-user (Clinics, Hospitals)

The global orthobiologics market is segmented and analyzed for demand and supply by end-user into clinics and hospitals, out of which, the hospitals segment is projected to witness noteworthy growth over the forecast period. The growth of the segment can be accounted to the rising patient pool in hospitals worldwide. For instance, in 2019, approximately 7% of the US population was noticed to be hospitalized.

Our in-depth analysis of the global orthobiologics market includes the following segmen

          By Solutions

  • Bone Graft Substitutes
  • Demoralized Bone Matrix
  • Bone Allografts
  • Bone Autographs
  • Bone Morphogenic Proteins
  • Bone Growth Stimulators
  • Visco-Supplementation
  • 5 and 3 Injection Visco-Supplementation
  • Single Injection Visco-Supplementation

           By Application

  • Spinal Fusion
  • Trauma Repair
  • Reconstructive Surgery

          By End-User

  • Clinics
  • Hospitals

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Orthobiologics Industry - Regional Synopsis

Regionally, the global orthobiologics market is studied into five major regions including North America, Europe, Asia Pacific, Latin America and Middle East & Africa region. Amongst these markets, the market in North America region is projected to hold the largest market share by the end of 2033. The growth of the market is ascribed to the rising geriatric population with severe bone diseases and the ongoing development in the healthcare expenditure of the region. As per the data published by the World Bank, it was noticed that the geriatric population in the United States reached 56,545,938 in 2021.

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Companies Dominating the Orthobiologics Landscape

    • Medtronic plc
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Wright Medical Group N.V. 
    • Zimmer Biomet Holdings, Inc.
    • Arthrex, Inc.
    • Medical Device Business Services, Inc.
    • Johnson & Johnson & Services, Inc.
    • RTI Surgical, Inc.
    • MTG Learning Media Pvt. Ltd.
    • Bioventus LLC
    • Stryker Corporation

In the News

  • Johnson & Johnson & Services, Inc.’s Janssen Pharmaceutical Company to announce its acquisition of U.S. FDA approval for IMBRUVIGA (ibrutinib). IMBRUVIGA is a BTKi treatment for pediatric patients with chronic graft-versus-host disease (cGVHD) after the failure of systemic therapy.
  • Zimmer Biomet Holdings, Inc. announces its three-year agreement with Hospital for special surgery (HSS). The agreement is established to make HSS/Zimmer Biomet (ZB) Innovation Center for Artificial Intelligence (AI).

Author Credits:  Radhika Pawar

  • Report ID: 773
  • Published Date: Feb 09, 2023
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

Increasing sales of orthopedic devices and rising cases of osteoporosis across the globe are estimated to majorly boost the market growth.

The market is anticipated to attain a CAGR of 6% over the forecast period, i.e., 2023-2033.

The lack of skilled medical professionals and requisite technology is estimated to challenge the market growth.

The market in North America region is projected to hold the largest market share by the end of 2033 and provide more business opportunities in the future.

The major players in the market are Wright Medical Group N.V., Zimmer Biomet Holdings, Inc., Arthrex, Inc., Medical Device Business Services, Inc., Johnson & Johnson & Services, Inc., RTI Surgical, Inc., MTG Learning Media Pvt. Ltd., and others.

The company profiles are selected based on the revenues generated from the product segment, the geographical presence of the company which determines the revenue-generating capacity as well as the new products being launched into the market by the company.

The market is segmented by solution, application, end-user, and by region.

The hospitals segment is anticipated to garner the largest market size by the end of 2033 and display significant growth opportunities.
Orthobiologics Market Report Scope

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