Hydroxyproline Market Size & Share, by Type (Pharmaceutical Grade, Industrial Grade); Application (Pharmaceutical Intermediate, Cosmetics, Food, Dietary Supplement) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2024-2036

  • Report ID: 4336
  • Published Date: Feb 05, 2024
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2024-2036

Hydroxyproline Market size is poised to reach USD 1 Billion by the end of 2036, growing at a CAGR of 6% during the forecast period, i.e., 2024-2036. In the year 2023, the industry size of hydroxyproline was USD 74 Million. The reason behind the growth is due to the growing beauty industry across the globe driven by the rising concern for one's well-being, rapid technological advancements, and altered perceptions of what constitutes "beauty”. For instance, the global industry of beauty and personal care products is expected to reach over USD 224 billion in 2028.

The growing usage of hydroxyproline in gelatin products is believed to fuel the hydroxyproline market growth. Hydroxyproline is a neutral heterocyclic protein amino acid found in many gelatin products that offers an ideal cell-attachment substrate for cell culture.

Hydroxyproline Market overview
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Hydroxyproline Market: Growth Drivers and Challenges

Growth Drivers

  • Rising Adoption of Collagen-Based Products – Hydroxyproline (HYP) is a collagen part of the protein and has an important role to play in the stabilization of the triple helix of collagen. For instance, hydroxyproline is also a type of non-essential amino acid, accounting for approximately 13% of the total amino acids of collagen.
  • Growing Geriatric Population- One of the most well-established indicators of bone resorption may be the growing knowledge among the older population of the significance of hydroxyproline which is possibly known for preserving healthy joints and bones.
  • Surging Prevalence of Liver Fibrosis- Most often, hydroxyproline is employed as a liver fibrosis diagnostic marker, which is the excessive build-up of collagen-primarily extracellular matrix (ECM) proteins.
  • Hydroxyproline in Dietary Supplements- Hydroxyproline is utilized as a source of dietary protein in the food business to promote collagen formation, skin health, and joint health to lessen aging symptoms and enhance skin health.


  • Side Effects associated with Hydroxyproline- A dietary supplement called hydroxyproline if used in high dosages, can have some very detrimental adverse effects including fatigue, headaches, dizziness, nausea, vomiting, diarrhea, and may raise blood pressure. Other side effects may also include heartburn and decreased appetite. In addition, rashes, pimples, and inflammation are common side effects of peptide synthesis on the skin that include swelling of the tongue or skin, stinging or tingling in the mouth, or on the skin where collagen is administered.
  • Lack of sensitivity at low concentrations can impact quality control processes
  • Huge Percentage of Variability can lead to inconsistent quality of the product
  • Restriction of Consumption in Various Occasions

Hydroxyproline Market: Key Insights

Base Year


Forecast Year




Base Year Market Size (2023)

~ USD 74 Million

Forecast Year Market Size (2036)

~ USD 1 Billion

Regional Scope

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
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Hydroxyproline Segmentation

Type (Pharmaceutical Grade, Industrial Grade)

The industrial grade segment in the hydroxyproline market is estimated to gain a robust revenue share of 55% in the coming years owing to the growing applications in cosmetic products. Dipalmitoyl hydroxyproline is a peptide that supports collagen which is used as an anti-aging chemical by cosmetic makers to their products to tone the skin while simultaneously boosting its anti-aging properties. It has anti-wrinkle and moisturizing qualities, and also inherent emulsifying qualities.

Dipalmitoyl hydroxyproline is a naturally produced component that is frequently used in anti-aging skin and lip care products since it is oil-soluble and enhances its absorption into the skin and lips. This substance functions best in combination with oils or glycols since they both heighten their skin-friendly properties and neutralize matrix metalloproteinases, which are enzymes that break down collagen.

A significant part of the protein collagen, hydroxyproline is believed to be essential for the stability of collagen the most prevalent protein, which is the primary constituent of connective tissues, that contributes to skin strength and may also improve moisture and suppleness.

In Addition, a pharmaceutical secondary standard called hydroxyproline is being researched for use in experimental medicine and is used as a pharmaceutical intermediate. like hydroxyproline is employed.  It is one of the primary components of connective tissue, including skin, bone, and cartilage, and is required for the healing of the injured area when these tissues are damaged.

Application (Pharmaceutical Intermediate, Cosmetics, Food, Dietary Supplement)

The food segment in the hydroxyproline market is set to garner a notable share shortly. In most nations, hydroxyproline, a nutritional supplement, is a widely used food additive and component as a supply of protein. The highest concentrations of hydroxyproline can be found in meat and bone meal, chicken by-product meal, and salmon proteins that are known to raise proline and hydroxyproline levels. Moreover, meat quality is routinely assessed using the measurement of hydroxyproline in meat products and is regarded as an appropriate criterion for identifying the quality of raw material used to make meat since meat contains connective tissue proteins, which reduce its softness.

Our in-depth analysis of the global hydroxyproline market includes the following segments:


  • Pharmaceutical Grade
  • Industrial Grade


  • Pharmaceutical Intermediate
  • Cosmetics
  • Food
  • Dietary Supplement

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Hydroxyproline Industry - Regional Synopsis

APAC Market Forecast

The hydroxyproline market in Asia Pacific is predicted to account for the largest share of 40% by 2036 impelled by the growing production and consumption of chemicals. China has the world’s largest chemical industry, which accounted for annual sales of approximately more than USD 1.5 trillion, or more than one-third of global sales, in recent years. Additionally, a vast consumer base and favorable government policies have boosted investment in China’s chemical industry. Easy availability of low-cost raw materials & and labor as well as government subsidies and relaxed environmental norms have served as a production base for key vendors globally. Particularly, India produced more than 28 million metric tons of petrochemicals and basic main chemicals in 2021. It ranks 6th in global chemical production. This statistic shows the lucrative opportunity for investment in businesses in Asia Pacific countries in the upcoming years.

North American Statistics

The North America hydroxyproline market is estimated to be the second largest, during the forecast timeframe led by the rising personal disposable income. For instance, the United States' disposable personal income rose by more than 0.2% in November 2023 compared to the same month the previous year. As a result, more and more individuals in the region can spend huge amounts on purchasing beauty and personal care products, which is expected to drive the demand for hydroxyproline market in the coming years.

Research Nester
Hydroxyproline Market size
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Companies Dominating the Hydroxyproline Market

    • KYOWA HAKKO BIO Co., Ltd
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Henan Senyuan Group Co., Ltd.
    • Evonik Industries AG
    • Fengchen Group Co.,Ltd
    • Merck Group
    • Thermo Fisher Scientific Holdings, Inc.
    • EnColl Corporation
    • Wuxi Jingyao Biotechnology Co., Ltd.
    • BASF SE
    • Wuhan Dico Chemical Co., Ltd.

In the News

  • Evonik Industries AG has inaugurated an Innovation Hub at its Allentown, Pa., site. The Research, Development & Innovation (RD&I) hub is made for several testing and processing labs as well as a pilot plant.
  • KYOWA HAKKO BIO Co., Ltd has launched a new dietary supplement ingredient IMMUSE, delivering a novel approach for broad-range immune support.

Author Credits:  Smruti Ranjan, Rajrani Baghel

  • Report ID: 4336
  • Published Date: Feb 05, 2024
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

The growing beauty industry across the globe and the growing sales of smartwatches are the major factors driving the growth of the market.

The market size of hydroxyproline is anticipated to attain a CAGR of 6% over the forecast period, i.e., 2024-2036.

The major players in the market are Henan Senyuan Group Co., Ltd., Evonik Industries AG, Fengchen Group Co.,Ltd, Merck Group, Thermo Fisher Scientific Holdings, Inc., EnColl Corporation, Wuxi Jingyao Biotechnology Co., Ltd., BASF SE, Wuhan Dico Chemical Co., Ltd., and others.

The industrial grade segment is anticipated to garner the largest market size by the end of 2036 and display significant growth opportunities.

The market in the Asia Pacific region is projected to hold the largest market share by the end of 2036 and provide more business opportunities in the future.
Hydroxyproline Market Report Scope

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