Human Organoids Market Trends

Growth Drivers

• Increasing number of organ transplantation procedures: The number of donors is much less than the number of people who need organ transplantation. According to data published by Penn Medicine in 2023, more than 100,000 people are waiting for transplantation in the U.S. Organoids are considered an alternative cell source for tissue engineering and aim to overcome the shortage of donors. These organoids are also helpful in drug testing of transplantation therapy. 

• Rising number of experiments in genetic science: Organoids are used as a tool to study gene function and cell development. The technology is used in investigating gene roles and studying cell development and functions. According to the World Economic Forum in April 2024, a USD 3.1 billion research program in the U.S. has already identified more than 275 million genetic variants that could help in creating health equity.  Moreover, preclinical drug testing of regenerative medicines uses human organoids in biomedical research.

Challenges

• Inadequate infrastructure for 3D cell culture: The availability of the necessary equipment to use advanced techniques is one of the prerequisites for conducting 3D cell culture-based research. Moreover, deploying the equipment and infrastructure of 3D cell culture demands huge capital and time.

• Difficulty in incorporating human organoids in workflows: The utility of the organoids is tempered by a variety of limitations such as limited maturation, and lack of high-fidelity cell types. Also, lack of standardization and variability in tissue sampling methods introduce challenges in organoid cultures.