Global Market Size, Forecast, and Trend Highlights Over 2025-2037
Hormone Refractory Prostate Cancer Market size was valued at USD 9 billion in 2024 and is anticipated to surpass USD 28.5 billion by 2037, registering a CAGR of 10.1% during the forecast timeline i.e. 2025-2037. In 2025, the industry size of hormone refractory prostate cancer is assessed at USD 9.9 billion.
The growth of market is experiencing robust growth owing to the global rise in the incidence of prostate cancer among elderly men. For instance, according to the World Cancer Research Fund, the 4th most frequent cancer in the world is prostate cancer, and second most prevalent type of cancer in men.
Highest prostate cancer incidence in 2022
Country |
Cancer Cases |
ASR/100,000 |
U.S. |
230,125 |
75.2 |
China |
134,156 |
9.7 |
Japan |
104,318 |
50.1 |
Germany |
65,269 |
54.2 |
India |
37,948 |
5.6 |
Source: World Cancer Research Fund
In addition, the extreme unmet clinical need for successful therapy in such late-stage advanced disease, together with CRPC's limited survival durations, drives the need for new therapies. Consistent and concerted R&D activity in the pharmaceutical and biotechnology industries are delivering a strong pipeline of novel new drugs and treatment approaches. For instance, in January 2025, the medication NXP800, which was developed at the Institute of Cancer Research in London showed that, it has restricted the growth of prostate cancer cells, including those that are resistant to the hormone therapy enzalutamide.

Hormone Refractory Prostate Cancer Sector: Growth Drivers and Challenges
Growth Drivers
- Aging men population: The growing number of aging men is a key driver for the hormone refractory prostate cancer (HRPCA) market. For instance, in August 2022, in the world as of 2021, there were roughly 44 million more men than women. In addition, there were 98 men for every 100 women in the U.S. in 2021 and is anticipated to reach 99 by 2050. As global life expectancy rises, older men's population increases, which means there are more individuals having a higher probability of developing prostate cancer and inevitably reaching castration-resistant status. Such a change in population actually directly accelerates demand for treatments, diagnostics, and palliative care.
- Robust research and development: The ongoing pursuit of new therapeutic targets and approaches presents a robust pipeline of medicines with potential to enhance patient outcomes and improve survival in the market. For instance, in April 2024, a novel androgen receptor inhibitor (ARI) was approved by the U.S. FDA. This allowed patients with non-metastatic castration-resistant prostate cancer (nmCRPC) to continue living their lives and has increased metastasis-free survival and has a favorable safety profile.
Challenges
- Disease variability and resistance: The ongoing demand for new solutions pose a remarkable challenge in the market. The second-line, third-line, and beyond therapy solutions require ongoing investment in drug development and market growth as clinicians struggle to keep pace with the changing morphology of resistant disease. The development of resistance to existing therapies inevitably generates a demand for newer, frequently more costly, therapies, further restrict market growth. Consequently, the very biological subtleties that make CRPC hard to fuel demand for and investment in more novel treatment paradigms.
- High treatment costs: The hormone refractory prostate cancer market faces a number of hurdles, chief among them being the high expense of treatment. The cost of new hormonal agents such as Provera can exceed cost beyond expected limit, making it less accessible in low- and middle-income countries than anticipated. This financial barrier hinders market expansion and highlights its growth potential, necessitating cost-effective options with financial assistance programs to make treatment accessible and increase market growth potential. Innovative therapies frequently place a significant financial burden on healthcare systems and patients alike.
Hormone Refractory Prostate Cancer Market: Key Insights
Base Year |
2024 |
Forecast Year |
2025-2037 |
CAGR |
10.1% |
Base Year Market Size (2024) |
USD 9 billion |
Forecast Year Market Size (2037) |
USD 28.5 billion |
Regional Scope |
|
Hormone Refractory Prostate Cancer Segmentation
Application (Hospitals, Specialty Clinics, Ambulatory Surgical Centers)
Hospital segment is likely to account for around 41.5% hormone refractory prostate cancer market share by 2037, due to the expanding infrastructural facilities across the world. For instance, in February 2025, as a part of NPCDCS initiative, the government has created 3,722 district day care centers, 770 district NCD clinics, 233 cardiac care units, and 6,410 community health center NCD clinics. These centers offer easily accessible and reasonably priced cancer screenings. Furthermore, to decentralize cancer treatment and increase access to services across states, it has improved specialist cancer care facilities with the founding of 19 State Cancer Institutes (SCIs) and 20 Tertiary Care Cancer Centers (TCCCs).
Treatment Type (Chemotherapy, Hormonal Therapy, Immunotherapy, Radiation Therapy, Surgery)
Based on treatment type, the hormonal therapy segment is expected to garner the major share in the hormone refractory prostate cancer (HRPCA) market by the end of 2037 attributed to its proven efficacy in curing the disease by acting on the androgen pathways essential for prostate cancer cell proliferation, thus occupying a large part of the therapeutic space. For instance, in January 2025, The US FDA has approved Enhertu (trastuzumab deruxtecan) from AstraZeneca and Daiichi Sankyo to treat adult patients with hormone receptor (HR)-positive, HER2-low (IHC 1+ or IHC 2+/ISH-) or HER2-ultralow (IHC 0 with membrane staining).
Our in-depth analysis of the global market includes the following segments:
Treatment Type |
|
Application |
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Customize this ReportHormone Refractory Prostate Cancer Industry - Regional Synopsis
North America Market Statistics
North America hormone refractory prostate cancer market is predicted to capture revenue share of over 41.7% by 2037. With continuous research to find biomarkers for response to current treatments and possible novel therapeutic targets, personalized therapy has enormous promise in HRPC within the region. Furthermore, prominent players are focusing on personalized medicine to save costs by directing resources toward therapies that have the best chance of succeeding, in improving patient outcomes.
The U.S. market is growing exponentially owing to the smooth regulatory approvals and procedures to push the growth of novel drug developments. For instance, in March 2025, to enable its use earlier in therapy, the U.S. FDA has extended the approval of 177Lu-PSMA-617 (Pluvicto). The treatment makes use of a molecule known as PSMA (prostate-specific membrane antigen), which specifically seeks for and binds to a certain protein on the surface of cancer cells. It emits radiation that kills the cancer cell and ruins DNA.
Canada hormone refractory prostate cancer market is likely to witness substantial growth during the forecast period attributed to the support from regulatory authorities in restricting the growth of cancer cases within the country. For instance, in November 2024, to improve statistics to guide breast cancer screening practices in Canada, the Canadian Partnership for Tomorrow's Health received USD 295,000 to probe into racial and ethnic variations in breast cancer screening participation, cancer treatments, and outcomes.
Asia Pacific Market Analysis
The hormone refractory prostate cancer (HRPCA) market in Asia Pacific is gaining traction and is expected to witness lucrative growth during the forecast timeline. The growth can be attributed to the increased demand for better healthcare treatment options fueled by rising disposable income. It further reflects a growing need for a higher quality of life. Additionally, rising educational attainment levels raise awareness of cancer types and suitable treatments is projected to propel the market growth during the stipulated timeframe.
India market is experiencing robust growth due to the local governments conducive support. For instance, in February 2025, the ICMR's National Cancer Registry Programme (NCRP) helps make evidence-based policy decisions by gathering and analysing the data. In addition, India established the Quad Cancer Moonshot in September 2024 with the goal of eradicating cervical cancer throughout the Indo-Pacific region in collaboration with the US, Australia, and Japan. It guaranteed early detection, efficient treatment, and increased survival rates. This effort seeks to expand screening and immunization programs, promote state-of-the-art research, and fortify international cooperation.
China market is exponentially scaling owing to the imperative initiatives taken by the local government to promote health and wellness. For instance, it was published by the National Library of Medicine that China's national strategy, Healthy China 2030, emphasizes the significance of China's commitment to the United Nations' 2030 Agenda for Sustainable Development. The government played an active participation in global health governance, and the importance of making people's health a developmental priority.

Companies Dominating the Hormone Refractory Prostate Cancer Landscape
- Astellas Pharma Inc
- Company Overview
- Business Strategy
- Key Product Offerings
- Financial Performance
- Key Performance Indicators
- Risk Analysis
- Recent Development
- Regional Presence
- SWOT Analysis
- AstraZeneca plc
- Johnson & Johnson
- Sanofi S.A.
- Novartis AG
- Pfizer Inc.
- Bayer AG
- Merck & Co.
- Eli Lilly and Company
- Takeda Pharmaceuticals
The key players in the market are striving to create a conducive environment for the biomarkers and competitors to expand their research to explore potential combination therapies and boost the clinical trials for novel drugs. For instance, in March 2022, Novartis announced that PluvictoTM was approved by the US FDA to treat adult patients with prostate-specific membrane antigen–positive metastatic castration-resistant prostate cancer (PSMA-positive mCRPC).
Here's the list of some key players:
In the News
- In January 2025, INmune Bio, Inc. announced that it is conducting a Phase I/II trial for men with metastatic castration-resistant prostate cancer (mCRPC) to create therapies that use the patient’s innate immune system to combat disease.
- In March 2024, Clarity entered the cancer trials for theranostic prostate cancer with multi-dose phase. At the highest dose examined in the study (12GBq), the Safety Review Committee (SRC) has suggested that the experiment move on to cohort 4, a multi-dose phase.
Author Credits: Radhika Pawar
- Report ID: 7560
- Published Date: Apr 25, 2025
- Report Format: PDF, PPT