Orthobiologics Market Size and Forecast, by Solutions {Bone Graft Substitutes (Demoralized Bone Matrix, Bone Allografts, Bone Autographs, Bone Morphogenic Proteins, Bone Growth Stimulators), Visco-Supplementation (5, 3 Injection Visco-Supplementation, Single Injection Visco-Supplementation)}, Application (Spinal Fusion, Trauma Repair, Reconstructive Surgery), End-user (Clinics, Hospitals) - Growth Trends, Key Players, Regional Analysis 2025-2034

  • Report ID: 773
  • Published Date: Jun 13, 2025
  • Report Format: PDF, PPT

Orthobiologics Market Outlook:

Orthobiologics Market size was valued at USD 7.03 billion in 2024 and is set to exceed USD 11.89 billion by 2034, registering over 5.4% CAGR during the forecast period i.e., between 2025-2034. In the year 2025, the industry size of orthobiologics is evaluated at USD 7.35 billion.

Key Orthobiologics Market Insights Summary:

  • North America is projected to maintain the largest market share by 2034.

  • The hospitals segment in the orthobiologics market is anticipated to experience significant growth during the forecast period.

  • Key Growth Trends:

    • Growing Number of Bone Fractures to Boost the Market Growth
    • Increasing Sales of Orthopedic Devices
  • Key Players:

    • Wright Medical Group N.V., Zimmer Biomet Holdings, Inc., Arthrex, Inc., Medical Device Business Services, Inc., Johnson & Johnson & Services, Inc., RTI Surgical, Inc., MTG Learning Media Pvt. Ltd.
  • By software type, the consolidated/integrated systems segment accounted for the largest market share of 69.33% in 2024 and is expected to grow at the fastest CAGR from 2025 to 2030.

Market Size and Growth Projections:

  • 2024 Market Size: USD 7.03 billion
  • 2025 Market Size: USD 7.35 billion
  • Projected Market Size: USD 11.89 billion by 2034
  • Growth Forecasts: 5.4% CAGR (2025-2034)
  • Largest Region: North America
  • Fastest Growing Region: North America

The market growth primarily be ascribed to rising cases of bone diseases across the globe. Based on the report provided by the National Library of Medicine (NLM), it was observed that around 1.5 million people suffer from fractures owing to some sort of bone disease every year.

Growing prevalence of low immunity and calcium deficiency owing to changing lifestyles and skyrocketing spending on medical technology are projected to influence the market revenue. As of 2019, the total revenue generated by medical technology was anticipated to be nearly USD 450 billion while the R&D spending on this technology was estimated to be around USD 30 billion in the same year. Orthobiologics is an injectable therapy that utilizes biological substances to heal musculoskeletal injuries rapidly. The substances used in the therapy are made from the materials naturally produced by the body.

Orthobiologics Market Size
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Growth Drivers

  • Growing Number of Bone Fractures to Boost the Market Growth- For instance, the estimated number of bone fractures received is approximately 1000 fractures per 100,000 people every year.
  • Increasing Sales of Orthopedic Devices- As of 2022, the orthopedic devices segment was valued at around USD 40 billion. A wide array of technologies is included in orthobiologics to improve the functionality of the broken bone. Components such as, scaffolds to reinforce tissue, cell therapies, and bone grafting materials are used in the therapy. Orthobiologics is associated with bone injuries, for instance, osteoporosis, osteonecrosis, bone infection, and density.
  • Higher Prevalence of Orthopedic Injuries- The prevalence of orthopedic injuries can be observed by the fact that more than 6 million orthopedic surgeries are performed every year solely in the USA.
  • Rising Cases of Osteoporosis Across the Globe- It is observed that 1 in 2 women and 1 in 5 men aged 50 or over suffer from osteoporosis globally. Furthermore, in 2017-18, more than 18% of women were predicted to be living with osteoporosis.
  • Significant growth in the Healthcare Expenditure- World Bank published statistics showing that in 2019, the healthcare expenditure reached 1,121.9 U.S. dollars per Capita.

Challenges

  • Higher Cost Associated with the Treatment
  • Lack of Skilled Medical Professionals and Requisite Technology
  • Presence of the Alternatives in the Market

Orthobiologics Market Size and Forecast:

Report Attribute Details

Base Year

2024

Forecast Year

2025-2034

CAGR

5.4%

Base Year Market Size (2024)

USD 7.03 billion

Forecast Year Market Size (2034)

USD 11.89 billion

Regional Scope

  • North America (U.S. and Canada)
  • Asia Pacific (Japan, China, India, Indonesia, South Korea, Malaysia, Australia, Rest of Asia Pacific)
  • Europe (UK, Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Latin America (Mexico, Argentina, Brazil, Rest of Latin America)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)

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Orthobiologics Market Segmentation:

End-user Segment Analysis

The hospitals segment in the orthobiologics market is projected to witness noteworthy growth over the forecast period. The growth of the segment can be accounted to the rising patient pool in hospitals worldwide. For instance, in 2019, approximately 7% of the US population was noticed to be hospitalized.

Our in-depth analysis of the global orthobiologics market includes the following segmen

          By Solutions

  • Bone Graft Substitutes
  • Demoralized Bone Matrix
  • Bone Allografts
  • Bone Autographs
  • Bone Morphogenic Proteins
  • Bone Growth Stimulators
  • Visco-Supplementation
  • 5 and 3 Injection Visco-Supplementation
  • Single Injection Visco-Supplementation

           By Application

  • Spinal Fusion
  • Trauma Repair
  • Reconstructive Surgery

          By End-User

  • Clinics
  • Hospitals
Vishnu Nair
Vishnu Nair
Head - Global Business Development

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Orthobiologics Market Regional Analysis:

The North America region is expected to hold majority market share by the end of 2034. The growth of the market can be ascribed to rising geriatric population with severe bone diseases and the ongoing development in the healthcare expenditure of the region. As per the data published by the World Bank, it was noticed that the geriatric population in the United States reached 56,545,938 in 2021.

Orthobiologics Market Share
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Key Orthobiologics Market Players:

    • Medtronic plc
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis
    • Wright Medical Group N.V. 
    • Zimmer Biomet Holdings, Inc.
    • Arthrex, Inc.
    • Medical Device Business Services, Inc.
    • Johnson & Johnson & Services, Inc.
    • RTI Surgical, Inc.
    • MTG Learning Media Pvt. Ltd.
    • Bioventus LLC
    • Stryker Corporation

Recent Developments

  • Johnson & Johnson & Services, Inc.’s Janssen Pharmaceutical Company to announce its acquisition of U.S. FDA approval for IMBRUVIGA (ibrutinib). IMBRUVIGA is a BTKi treatment for pediatric patients with chronic graft-versus-host disease (cGVHD) after the failure of systemic therapy.
  • Zimmer Biomet Holdings, Inc. announces its three-year agreement with Hospital for special surgery (HSS). The agreement is established to make HSS/Zimmer Biomet (ZB) Innovation Center for Artificial Intelligence (AI).
  • Report ID: 773
  • Published Date: Jun 13, 2025
  • Report Format: PDF, PPT

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Frequently Asked Questions (FAQ)

In the year 2025, the industry size of orthobiologics is evaluated at USD 7.35 billion.

Orthobiologics Market size was valued at USD 7.03 billion in 2024 and is set to exceed USD 11.89 billion by 2034, registering over 5.4% CAGR during the forecast period i.e., between 2025-2034.

North America is anticipated to hold largest industry share by 2034.

The key market players include Wright Medical Group N.V., Zimmer Biomet Holdings, Inc., Arthrex, Inc., Medical Device Business Services, Inc., Johnson & Johnson & Services, Inc., RTI Surgical, Inc., MTG Learning Media Pvt. Ltd., and others.
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Radhika Pawar
Radhika Pawar
Senior Research Analyst
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