Leucovorin Calcium Market Size & Share, by Route of Administration (Oral, Injectable); End-user (Hospital, Retail Pharmacies, Specialty Clinics) - Global Supply & Demand Analysis, Growth Forecasts, Statistics Report 2023-2035

  • Report ID: 4020
  • Published Date: May 01, 2023
  • Report Format: PDF, PPT

Global Market Size, Forecast, and Trend Highlights Over 2023-2035

Leucovorin Calcium Market size is estimated to cross USD 33 million by the end of 2035, witnessing around 16% CAGR during the forecast period, i.e., 2023-2035. In the year 2022, the industry size of leucovorin calcium was USD 20 million. The growth of this market can be attributed to the growing presence of cancer patients globally. Leucovorin calcium is widely used to treat cancer patients in the chemotherapy process it is used as an effective drug in the treatment. In 2020, around 20 million cancer cases were recorded all over the world.

Rising blood cells disorder such as anemia, thrombocytopenia, and neutropenia that is caused by high doses of an antagonist such as methotrexate, trimethoprim, and pyrimethamine are significant factor anticipated to drive the industry growth. In addition, growing cases of megaloblastic anemia caused by folic acid deficiency are expected to drive the market growth of the leucovorin calcium market in the forecast period. Leucovorin calcium is used to treat megaloblastic anemia in cases when oral therapy is not feasible. About 1 in 7.5 thousand people develop megaloblastic anemia in the United States every year.

Leucovorin Calcium Market
Get more information on this report: Request Free Sample PDF

Leucovorin Calcium Sector: Growth Drivers & Challenges

Growth Drivers

  • Increasing Prevalence of Colon-Rectal Cancer – Leucovorin calcium is a medication commonly used as rescue therapy in combination with fluorouracil to treat colon and rectal cancer. This drug helps improve the efficacy of fluorouracil and reduce its toxicity. The increasing prevalence of colorectal cancer is a significant driver of the leucovorin market as leucovorin is an integral part of chemotherapy regimens for the disease. In 2020, 1 million cases of colon rectal cancer were recorded in the United States.
  • Growing Cancer Awareness amongst People –Increasing awareness of cancer amongst the general population is a key factor driving the market. As people become more aware of the signs and symptoms of cancer and the importance of early detection, they are more likely to see a doctor and receive appropriate treatment, including the use of leucovorin calcium.   More than 40% population gets diagnosed with cancer at an early stage.
  • Growing Prevalence of Megaloblastic Anemia – When oral medication is not an option, leucovorin calcium is used to treat megaloblastic anemia, and is further anticipated to fuel market expansion over the forecast period. Additionally, folic acid or vitamin B12 deficiency may result in megaloblastic anemia. Leucovorin calcium, aids in the restoration of normal cell division and maturation by giving the body a source of folic acid which can be used to create new red blood cells, further being a key medication in the treatment of megaloblastic anemia. Around 1.4% cases of megaloblastic anemia cases are caused by B12 deficiency.
  • Growing Prevalence of Cancer in Developed and Developing Countries – Rising presence of cancer among people situated in developed and developing countries is anticipated to propel the growth of this market in the forecast period. In developed countries, cancer rates are high owing to factors such as increased life expectancy and the adoption of unhealthy lifestyles. As developing countries undergo rapid industrialization and modernization, cancer rates are also increasing, leading to lifestyle changes and exposure to environmental risk factors. Leucovorin calcium is commonly used as a component of chemotherapy regimens for many types of cancer, including colon, stomach, and ovarian cancer. For instance, according to studies 225,800 new cases of cancer were recorded in Canada in 2020. 


  • Non-compatibility with other Drugs – Leucovorin calcium has some compatibility problems with various drugs such as capecitabine, and cotrimoxazole and also, leucovorin calcium reacts with breastfeeding, pregnant women, children, people with seizer problems, and geriatric population undergoing this medication must be kept under special monitoring. This factor might restrict the market to growth in the forecast period.
  • High Cost Associated with Cancer Treatment
  • Side Effects of Cancer Treatment Drugs

Leucovorin Calcium Market: Key Insights

Base Year


Forecast Year

2023 - 2035



Base Year Market Size (2022)

~USD 20 million

Forecast Year Market Size (2035)

~USD 33 million

Regional Synopsis

  • North America (U.S., and Canada)
  • Latin America (Mexico, Argentina, Rest of Latin America)
  • Asia-Pacific (Japan, China, India, Indonesia, Malaysia, Australia, Rest of Asia-Pacific)
  • Europe (U.K., Germany, France, Italy, Spain, Russia, NORDIC, Rest of Europe)
  • Middle East and Africa (Israel, GCC North Africa, South Africa, Rest of the Middle East and Africa)
Get more information on this report: Request Free Sample PDF

Leucovorin Calcium Segmentation

End-user (Hospital, Retail Pharmacies, Specialty Clinics)

The global leucovorin calcium market is segmented and analyzed for demand and supply by end users into hospitals, retail pharmacies, specialty clinics, and others. Out of these, the hospital segment is anticipated to hold the largest market share by the end of 2035. The expansion of the healthcare system and the fact that the drug is not widely accessible and must be purchased with a prescription from a doctor both contribute to the market's growth. Also, the presence of growing cases of cancer and critical blood cell disorder raises the demand for the hospital segment globally. For instance, 1.25 million new instances of blood cancer, or about 6% of all cancer cases, are recorded annually. Leucovorin calcium is typically used for the treatments such as Hodgkin's lymphoma, ovarian cancer, colorectal cancer, and brain tumors. Leucovorin calcium has been used more frequently in hospital pharmacies as a result of its expanding potential for treating various malignancies, particularly colon cancer.

Route of Administration (Oral, Injectable)

The global leucovorin calcium market is segmented and analyzed for demand and supply by route of administration into oral, injectable, and others. Out of these, the injectable segment is anticipated to hold the largest market share by the end of 2035. Leucovorin is a medicine that consists of an active ingredient named leucovorin. It appears in injection form for application by intravenous infusion, intramuscularly into the under the skin of the stomach, muscle, or arm. The injection is found at API with sodium chloride, water for injection, and sodium hydroxide, or hydrochloric acid as a buffer.

Our in-depth analysis of the global market includes the following segments:

         By Route of Administration

  • Oral
  • Injectable
  • Others

         By End User

  • Hospital
  • Retail Pharmacies
  • Specialty Clinics
  • Others

Want to customize this research report as per your requirements? Our research team will cover the information you require to help you take effective business decisions.

Customize this Report

Leucovorin Calcium Industry - Regional Synopsis

North American Market Forecast   

The market in the North American region is also estimated to gain the largest growth by the end of 2035. This can be attributed owing to the presence of major pharmaceutical companies in the region backed by the high healthcare expenditure in the developed countries. As per the data by the U.S. Centers for Medicare & Medicaid Services, the national healthcare expenditure grew by 9.7% to USD 4.1 trillion in 2020. Owing to the presence of significant important companies and advanced healthcare infrastructure in the area, North America is anticipated to hold the biggest market share. Also, a rising number of people with blood disorders and colorectal cancer patients are boosting the region's leucovorin calcium market.

Europe Market Forecast

The market in the Europe region is estimated to witness noteworthy growth by the end of 2035. This can be attributed to the growing prevalence of cancer, along with the efficient healthcare system in the region. Europe is one of those countries in the world that has favorable health care policies and also has enhanced health care practices for the treatment of cancer. Countries such as Germany, and the UK have favorable reimbursement policies and established regulatory frameworks, they focus on patient safety, constantly monitor patients' health while the treatment is going on, and also treatment efficiency standards are high level these are a few significant factors that are estimated to drive the market growth.

APAC Market Statistics

The market in the Asia Pacific region is also anticipated to hold a significant market share by the end of 2035. Geriatric population growth; infrastructural improvements in the healthcare sector; and an increase in R&D activity in Asia-Pacific developing countries. Increasing product recalls since leucovorin calcium-drug interactions and supply problems as a result of restrictions on the import of raw materials into the United States, China, and India are a few of the challenges facing the worldwide leucovorin calcium market. Throughout the forecast period, an increase in launch prices is anticipated to present growth prospects for businesses active in this market. Moreover, the market is also expected to grow with the improving healthcare infrastructure in the region and growing awareness about cancer disease, its causes, and its treatment options in the region.

Research Nester
Leucovorin Calcium Market Size
Get more information on this report: Request Free Sample PDF

Companies Dominating the Leucovorin Calcium Landscape

    • Exelixis Inc.
      • Company Overview
      • Business Strategy
      • Key Product Offerings
      • Financial Performance
      • Key Performance Indicators
      • Risk Analysis
      • Recent Development
      • Regional Presence
      • SWOT Analysis 
    • PromoCell GmbH
    • Thermo Fisher Scientific Inc.
    • Boehringer Ingelheim GmbH
    • Bayer AG
    • Abbott Laboratories
    • Merck & Co., Inc.
    • Mylan N.V.
    • Novartis International AG
    • Pfizer Inc.

In the News

  • Exelixis Inc. announced the successful results for Cabozantinib in combination with immunotherapies in patients with advanced colorectal cancer. 
  • PromoCell GmbH to lead research on immunotherapies through all human primary cells and blood & stem cells, including MHC class I genes HLA-A, -B, and -C.

Author Credits:  Radhika Pawar

  • Report ID: 4020
  • Published Date: May 01, 2023
  • Report Format: PDF, PPT

Frequently Asked Questions (FAQ)

The increasing prevalence of colorectal cancer and rising cancer awareness are some of the major factors anticipated to drive the growth of the leucovorin calcium market.

The market is anticipated to attain a CAGR of 16% over the forecast period, i.e., 2023 – 2035.

The High cost of cancer treatment is estimated to hamper the market growth.

The market in North America is projected to hold the largest market share by the end of 2035 and provide more business opportunities in the future.

The major players in the market are Abbott Laboratories, Merck & Co., Inc., Mylan N.V., Novartis International AG, Pfizer Inc., and others.

The company profiles are selected based on the revenues generated from the product segment, the geographical presence of the company which determines the revenue generating capacity as well as the new products being launched into the market by the company.

The market is segmented by end-user, route of administration, and by region.

The hospital segment is anticipated to garner the largest market size by the end of 2035 and display significant growth opportunities.
Leucovorin Calcium Market Report Scope

FREE Sample Copy includes market overview, growth trends, statistical charts & tables, forecast estimates, and much more.

 Request Free Sample Copy

Have questions before ordering this report?

Inquiry Before Buying