Introduction to Transdermal Patch Drug Delivery System
Transdermal patch is the method to deliver drugs through skin directly into the bloodstream. The patches provide controlled, constantly administered drugs that are easily consumable, have minimum side effects and are non-invasive. The drug delivery patches mainly have a layer of polymer matrix, drug, permeation enhancer and adhesive. The transdermal patches have a leading edge over the other injectable and oral systems owing to the avoidance of first-pass metabolism and ease of maintaining drug concentration.
There are mainly three ways in which the drug molecule can permeate through skin into body – shunt routes, intercellular lipid domains and trans-cellular routes. The transdermal patches ensures that the medicated substances reach to the vivo location with minimum side effects. These are based on backing laminators, liners and plasticizers that ensure good adhesion and efficient drug release via skin in form of systemic circulations for several hours or days.
Market Size and Forecast
The global transdermal patch drug delivery system market is anticipated to record a CAGR of around 6.0% over the forecast period, i.e. 2019-2027 owing to increase in chronic diseases and growing awareness among the people. The painless application and non-invasive nature of transdermal patches, coupled with the rise in geriatric population is anticipated to increase the market growth during the forecast period.
The market is segmented by application into pain management, central nervous system, hormonal application, cardiovascular disease and others, out of which the pain management segment is anticipated to witness leading market share owing to increase in chronic pain cases, as a result of inclination towards unhealthy lifestyle, coupled with better pain relief mechanism processes of the transdermal patch drug delivery system. Furthermore, growing diseases amongst people, for instance, migraine, cervical spondylitis, atherosclerosis, heart disease and diabetes among others, is expected to boost the demand of transdermal patch drug delivery system during the forecast period.
The market of transdermal patch drug delivery system is also segmented by type into fentanyl, nitroglycerine, estradiol, nicotine and others, out of which, the fentanyl segment is expected to witness gain in market share on the back of its use in treating severe pain, specifically after surgery and for treating patients who are intolerant to other low dose opioids. DOWNLOAD SAMPLE REPORT HERE
Growing Medical Advancements
Medical advancements in the field of transdermal patch drug delivery system, for instance, TEPI patches and others, is anticipated to drive the market growth. The TEPI patch technology utilizes adhesives that are pressure sensitive and remains in contact with skin throughout the dosing period. The rate of drug release can be adjusted in accordance to the required pharmacokinetic profile coupled with adhesives that have high loading capacity owing to which wide range of medium can be used. Additionally, the manufacturing of these patches have easy processes, are environment friendly, and require no organic solvents, which is also anticipated to raise the demand for transdermal patch drug delivery system market.
Rapid Development in Product Features
Rapid developments in the features of transdermal patches, for instance, prolonged therapeutic effect, improved bio availability and ease of application among others, is anticipated to drive the market growth over the forecast period. Furthermore, transdermal patches have observed rapid demand for its utilization in cases where patients could not consume heavy oral doses, or drugs that get effected by gastro intestinal enzymes and for unconscious patients.
Restrictions in Form, Shape and Size
The patches deliver drug dosage through skin which implies that the drug molecule should be small enough to penetrate through as the skin acts as the barrier to any environmental impurity that tries to enter the body. Owing to this the drug molecule that can be delivered through transdermal patch has limitation of size, weight which should be less than 500Da coupled with aqueous and lipid solubility. Additionally, these patches when applied on the skin causes irritation, erythema and local edema at times owing to the drug or adhesive used.
Competition from Oral Pharmaceuticals
Continuous medical advancements have resulted in the development of oral pharmaceuticals and medication facilities which have improved features and specifications in drug delivery system. Oral dosage process is accepted more than pushing injections amongst the patients, which might restraint the growth of the market. All of these factors are anticipated to act as a barrier to the growth of the transdermal patch drug delivery system market.
Our-in depth analysis of the transdermal patch drug delivery system market includes the following segments:
By Product type
By End User
On the basis of regional analysis, transdermal patch drug delivery system market is segmented into five major regions including North America, Europe, Asia Pacific, Latin America and Middle East & Africa region.
North America is anticipated to hold leading market share owing to the presence of numerous drug manufacturers along with the presence of key players into the pharmaceutical industry in the region. Moreover, rising unhealthy lifestyle habits of people in the region, which is raising diseases such as chronic ailments and pain, coupled with rise in the number of research and development activities, is expected to drive the market growth in the region.
Europe is expected to witness significant growth in market share on the back of increasing skin disease incidences and rise in adoption of patch drug delivery system amongst healthcare officials as a pain free system. Additionally, the rise in private sector investment in the healthcare sector is anticipated to boost the market growth in the region.
The transdermal patch drug delivery system market is further classified on the basis of region as follows:
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